| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| Other Sizes |
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| ln Vivo |
In pharmacological testing, zolazomin is frequently utilized as a practical marker of alterations in rodent cytochrome P-450 function. Based on test concentration data, the time-averaged serum clearance of zoxazomin was 7.22 ± 1.01 mL/min/kg. When zoxazomin was infused into the righting reflex (LRR) at three different rates, the concentrations of the drug in the brain and serum rose as soon as the action began. The concentration of zoxazomin in the cerebrospinal fluid (CSF) at the time of the LRR excursion is nearly identical to the starting concentration when the infusion is sustained for five minutes following the occurrence of LRR [1].
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| References | |
| Additional Infomation |
Zoxazolamine is a benzoxazole.
A uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood. |
| Molecular Formula |
C7H5CLN2O
|
|---|---|
| Molecular Weight |
168.5804
|
| Exact Mass |
168.009
|
| CAS # |
61-80-3
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| PubChem CID |
6103
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| Appearance |
Off-white to light brown solid powder
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| Density |
1.481 g/cm3
|
| Boiling Point |
316.8ºC at 760 mmHg
|
| Melting Point |
181-184 °C(lit.)
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| Flash Point |
145.4ºC
|
| Index of Refraction |
1.692
|
| LogP |
2.644
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
11
|
| Complexity |
155
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
YGCODSQDUUUKIV-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H5ClN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10)
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| Chemical Name |
5-chloro-1,3-benzoxazol-2-amine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~593.19 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.83 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.9319 mL | 29.6595 mL | 59.3190 mL | |
| 5 mM | 1.1864 mL | 5.9319 mL | 11.8638 mL | |
| 10 mM | 0.5932 mL | 2.9660 mL | 5.9319 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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