|
V0411
|
(+)-JQ1 |
1268524-70-4 |
(+)-JQ1 is a novel, potent and highly specific BET (Bromodomain and extra terminal domain) bromodomain inhibitor with antineoplastic activity. |
|
V0284
|
Sodium Phenylbutyrate (4-PBA sodium) |
1716-12-7 |
Sodium phenylbutyrate (4-Phenylbutyric acid sodium; 4-PBA sodium),an orphan drug marketed by Ucyclyd Pharma, is a novel and potent histone deacetylase (HDAC) inhibitor used as an as adjunctive therapy for chronic treatment of urea cycle disorders involving deficiencies of argininosuccinic acid synthetase (AS), ornithine transcarbamylase (OTC), or carbamylphosphate synthetase (CPS). |
|
V0300
|
Olaparib (AZD2281; KU0059436) |
763113-22-0 |
Olaparib (formerly also known as AZD-2281; KU-59436; KU0059436; trade name Lynparza) is a potent,novel and orally bioavailable small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential anticancer activity. |
|
V0493
|
Foretinib (GSK-1363089; XL-880; EXEL2880; GSK-089) |
849217-64-7 |
Foretinib (also known as GSK1363089; XL880; EXEL-2880; GSK089) is a novel, potent, ATP-competitive small-molecule inhibitor of multipletyrosine kinases (e. |
|
V0611
|
AZD3463 |
1356962-20-3 |
AZD-3463 (AZD3463) is a novel, potent and selective ALK/IGF1R inhibitor with potential anticancer activity. |
|
V0001
|
Venetoclax (ABT-199; GDC-0199) |
1257044-40-8 |
Venetoclax (formerly known as ABT-199 or GDC-0199; Venclexta) is a potent, selective andorally bioavailablesmall molecule inhibitor of theanti-apoptotic protein BCL-2 (B-cell lymphoma-2) with Ki of<0.01 nM. |
|
V51454
|
KRA-533 |
10161-87-2 |
KRA-533 is a selective KRAS agonist. |
|
V0075
|
AZD1390 |
2089288-03-7 |
AZD1390 (AZD-1390) is a novel, potent, selective, first-in-class orally bioavailable and CNS penetrant inhibitor of Ataxia-telangiectasia mutated (ATM) kinase with potential anticancer activity. |
|
V0024
|
Belnacasan (VX765) |
273404-37-8 |
Belnacasan (also known as VX-765) is a novel, potent, selective and orally bioactive prodrug of VRT-043198 which is a potent and selective inhibitor of caspase-1 withKi values of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. |
|
V0503
|
Apatinib (Rivoceranib, YN968D1) |
811803-05-1 |
Apatinib (formerly known as Rivoceranib,YN-968D1) is a potent, orally bioavailable, and selective inhibitor of the VEGF (vascular endothelial growth factor receptor) signaling pathway withpotential antiangiogenic and antineoplastic activities. |
|
V0174
|
Rapamycin (Sirolimus; AY22989) |
53123-88-9 |
Rapamycin (also known as Sirolimus; AY-22989), a natural macrocyclic lactone isolated from the bacterium Streptomyces hygroscopicus, is a specific and potent mTOR inhibitor with IC50 of ~0.1 nM in HEK293 cells. |