Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus.The receptor separates from supporting proteins after binding the hormone ligand, moves into the nucleus, dimerizes, and then activates transcription of androgen-responsive genes. The progesterone receptor is most similar to the androgen receptor, and progestins can block the androgen receptor when used in larger doses. The androgen receptor's primary role is that of a DNA-binding transcription factor that controls gene expression. The formation and maintenance of the male sexual phenotype depend heavily on genes that are influenced by androgen. Complete androgen insensitivity (CAIS) is a condition that is also correlated with mutations in this gene.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V67625 | (Des-Glu5)-ACTH (1-24) (human, bovine, rat) | 1815617-95-8 | (Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analog of adrenocorticotropic hormone (ACTH). |
|
V67597 | (R)-Bicalutamide ((R)-Bicalutamide) | 113299-40-4 | (R)-Bicalutamide is the R-enantiomer of Bicalutamide. |
|
V67632 | (R)-SKBG-1 | 2955634-67-8 | (R)-SKBG-1 is an inhibitor (blocker/antagonist) of the RNA-binding protein NONO. |
|
V67626 | (Rac)-PF-998425 | 1076225-26-7 | (Rac)-PF-998425 is a specific, non-steroidal androgen receptor (AR) antagonist. |
|
V67617 | 11-Ketodihydrotestosterone-d3 (11-KDHT-d3; 5α-Dihydro-11-keto testosterone-d3) | 2479914-02-6 | 11-Ketodihydrotestosterone-d3 is the deuterated form of 11-Ketodihydrotestosterone. |
|
V67603 | 11-Ketotestosterone (11-Oxotetestosterone) | 564-35-2 | 11-Ketotestosterone (11-Oxotestosterone), an oxidized form of Testosterone, is an active androgen. |
|
V67620 | A4B17 | 2759918-91-5 | A4B17 is an androgen receptor N-terminal inhibitor studied in androgen-responsive prostate cancer. |
|
V8411 | AC-262536 | 870888-46-3 | AC-262536 (AC262536) is anovel selective androgen receptor modulator (SARM) with beneficial anabolic effects. |
|
V67629 | Acetyl-ACTH (2-24) (human, bovine, rat) | 1815617-98-1 | Acetyl-ACTH (2-24) (human, bovine, rat) is a fragment of the promelanocortin (POMC) peptide. |
|
V67638 | Acetyl-ACTH (3-24) (human, bovine, rat) | 1815617-99-2 | Acetyl-ACTH (3-24) (human, bovine, rat) is a fragment of the promelanocortin (POMC) peptide. |
|
V67614 | Acetyl-ACTH (4-24) (human, bovine, rat) | 1815618-00-8 | Acetyl-ACTH (4-24) (human, bovine, rat) is a fragment of the promelanocortin (POMC) peptide. |
|
V67639 | Acetyl-ACTH (7-24) (human, bovine, rat) | 1815618-01-9 | Acetyl-ACTH (7-24) (human, bovine, rat) causes a significant reduction in ACTH-induced corticosterone and aldosterone release. |
|
V77287 | Adrenocorticotropic hormone TFA (ACTH TFA; Adrenocorticotrophic hormone TFA) | Adrenocorticotropic hormone (ACTH) TFA is an adrenocorticotropic hormone secreted by the anterior pituitary gland. | |
|
V67621 | Androgen receptor antagonist 7 | 2409791-89-3 | Androgen receptor antagonist 7 is a potent androgen receptor (AR) antagonist (inhibitor) with IC50 of 1.18 µM. |
|
V67637 | Androgen receptor antagonist 8 | 1572045-29-4 | Androgen receptor antagonist 8 (Example 13) is an androgen receptor antagonist. |
|
V67609 | Androgen receptor antagonist 9 | 915086-32-7 | Androgen receptor blocker (antagonist) 9 (compound 28) is an antagonist of the androgen receptor. |
|
V67615 | Androgen receptor degrader-1 | 2616553-35-4 | Androgen receptor degrader-1 (compound 18) is a potent androgen receptor degrader. |
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V67630 | Androgen receptor degrader-2 | 2616553-33-2 | Androgen Receptor degrader-2 (compound 9) is a potent androgen receptor degrader. |
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V67624 | Androgen receptor degrader-3 | 2753650-84-7 | Androgen receptor degrader-3 is a selective androgen receptor degrader. |
|
V67623 | Androgen receptor-IN-5 | 1391944-16-3 | Androgen Receptor-IN-5 is an androgen receptor blocker/inhibitor (antagonist) with effective anti-cancer effects. |
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