STAT

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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STAT

STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.Initially, STAT proteins were thought to be dormant cytoplasmic transcription factors that needed to be phosphorylated in order to be retained in the nucleus. While awaiting an activation signal, the unphosphorylated STAT proteins move back and forth between the cytosol and the nucleus. The transcription of cytokine-inducible genes is activated once the activated transcription factor enters the nucleus and binds to the consensus DNA-recognition motif known as gamma-activated sites (GAS) in the promoter region.

STAT related products

Cat No.	Product Name	CAS No.	Product Description
V69139	(R)-Lisofylline ((R)-Lisophylline)	100324-81-0	(R)-Lisofylline ((R)-Lisophylline) is the (R)-enantiomer of the Pentoxifylline metabolite and has anti-inflammatory activities.
V69136	Angoline	21080-31-9	Angoline is a potent and specific inhibitor of the IL6/STAT3 signaling pathway with IC50 of 11.56 μM.
V69143	Angoline hydrochloride	1071676-04-4	Angoline HCl is a potent and specific inhibitor of the IL6/STAT3 signaling pathway with IC50 of 11.56 μM.
V69156	Antitumor agent-73	2812356-72-0	Antitumor agent-73 is an analogue of Diosgenin, which can inhibit the STAT3 signaling pathway and exogenously activate Pdia3/ERp57.
V69144	APT STAT3	1345420-96-3	APT STAT3 is a specific STAT3-binding peptide.
V2981	AS1517499	919486-40-1	AS1517499 is a potent STAT6 inhibitor with IC50of 21 nM.
V2547	BP-1-102	1334493-07-0	BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, which binds Stat3 with an affinity Kd of 504 nM.
V69157	Eflepedocokin alfa	2200269-84-5	Eflepedocokin alfa is a recombinant fusion protein with potential cytoprotective activity.
V22020	GYY 4137 morpholine salt	106740-09-4	GYY 4137 morpholine salt (GYY-4137; GYY4137; ZYJ1122; ZYJ-1122) is a novel, water-soluble and slow releasing Hydrogen sulfide (H2S) donor.
V76918	HP590	2971855-37-3	HP590 is an orally bioactive, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM).
V22577	inS3-54-A18	328998-53-4	inS3-54A18 is a potent STAT3 inhibitor (antagonist) with anti-cancer effects.
V69138	ML115	912798-42-6	ML115 is a molecular probe for signaling transducers and transcriptional activators.
V69151	Neocucurbitacin A	352359-53-6	Neocucurbitacin A (compound 7) is a STAT3 inhibitor found in agarwood peel.
V7042	RO8191	691868-88-9	RO8191(RO-8191; CDM-3008) is a novel and potent activator of JAK/STAT pathway andinterferon α receptor type 2 (IFNAR2) with antiviral effects.
V67544	ROCK2-IN-7	3000541-95-4	ROCK2-IN-7 is a kinase inhibitor targeting ROCK2.
V69140	Salviolone	119400-86-1	Salviolone is a natural diterpene analogue that fights melanoma cells.
V2551	STA-21	111540-00-2	STA-21(NSC628869; Ochromycinone; STA21; Rac-STA-21)is a potent STAT3 inhibitor and natural antibioticwith anticancer and antimicrobial activity.
V69159	Stafia-1	2582757-90-0	Stafia-1 is a potent inhibitor of STAT5a (K i=10.9 μM, IC50=22.2 μM).
V69160	Stafia-1-dipivaloyloxymethyl ester	2582755-72-2	Stafia-1-dipivaloyloxymethyl ester (compound 27) is a potent and specific STAT5a inhibitor.
V69141	Stafib-2	2097938-74-2	Stafib-2 is a potent and specific inhibitor of the transcription factor STAT5b, with IC50s of 82 nM and 1.7 μM for STAT5b and STAT5a inhibition, respectively.