c-FMS (CSF1R, CSF-1R) is a receptor protein-tyrosine kinase of the platelet-derived growth factor receptor (PDGFR) family. The cell surface receptor for IL-34 and CSF1 is called c-FMS. Important functions of c-FMS include regulating haematopoiesis, cell survival, maturation of microglia and monocytes, and immune response regulation.
Osteoclasts and myelomonocytic-lineage cells, like monocytes and macrophages, express c-FMS specifically, and the activation of c-FMS signaling encourages the proliferation or differentiation of these cells. Additionally, it encourages the production of inflammatory mediators like interleukin 6 (IL6) and tumor necrosis factor-alpha (TNF-).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V93767 | Enrupatinib | 2222689-47-4 | Enrupatinib is a colony-stimulating factor 1 receptor (CSF1R) inhibitor with antitumor activity. |
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V69289 | IACS-9439 | 2231259-36-0 | IACS-9439 is a specific, orally bioactive CSF1R inhibitor (antagonist) with a Ki of 1 nM. |
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V23228 | KI-20227 | 623142-96-1 | KI-20227 is a potent and orally bioavailable inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). |
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V69271 | Pimicotinib (ABSK021) | 2253123-16-7 | Pimicotinib is a CSF1R inhibitor (antagonist) with anti-tumor activity. |
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V103426 | Pimicotinib hydrochloride | 2866305-19-1 | Pimitinib hydrochloride is a CSF1R inhibitor with antitumor activity. |
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V5141 | PLX-647 | 873786-09-5 | PLX-647 (PLX647) is a novel, potent and highly specific dual FMS/KIT kinase inhibitor with anticancer activity. |
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V16640 | PLX5622 fumarate | 2749102-07-4 | PLX5562 is a highly selective, orally bioactive and CNS-penetrant CSF1R inhibitor. |
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V69285 | PLX647 dihydrochloride | 1779796-38-1 | PLX647 di-HCl is an orally bioactive, specific dual kinase inhibitor of FMS and KIT with IC50 of 28 and 16 nM, respectively. |
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V87999 | PXB17 | PXB17 can inhibit CSF1R (IC50 = 1.7 nM) by blocking the activation of PI3K/AKT/mTORC1 signaling. | |
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V105664 | Pyrithyldione | 77-04-3 | Pyridinedione is a sedative-hypnotic drug that can induce agranulocytosis. |
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V3765 | Edicotinib | 1142363-52-7 | Edicotinib (formerly known as JNJ-527; JNJ-40346527) is a novel selective and orally bioavailable inhibitor of colony-stimulating factor-1 (CSF-1) receptor kinase with anticancer activity. |
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V14353 | Pexidartinib HCl | 2040295-03-0 | Pexidartinib HCl (formerly also know as PLX-3397 HCl) is a novel, orally bioavailable, potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. |
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