FGFR (Fibroblast growth factor receptors) are the receptors that bind to members of the fibroblast growth factor family of proteins.Pathological conditions involve some of these receptors. Achondroplasia can be brought on by a point mutation in FGFR3. Vertebrates have been found to contain five distinct membrane FGFRs, all of which are members of the tyrosine kinase superfamily (FGFR1, FGFR2, FGFR3, FGFR4, FGFR6). One of the most significant families of paracrine factors that function in the development process is the fibroblast growth factor family. They control which cells differentiate into mesoderm, the production of blood vessels, the growth of limbs, and the growth and differentiation of many different cell types.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69466 | FGFR-IN-11 | 2658488-68-5 | FGFR-IN-11 (compound I-5) is an orally bioactive and covalent pan-FGFR inhibitor (antagonist) with IC50s of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3) and 1.8 respectively. |
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V69464 | FGFR-IN-12 | 943189-02-4 | FGFR-IN-12 (example 14) is a pyrimidinyl aryl urean analogue and a potent FGFR inhibitor. |
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V88036 | FGFR-IN-13 | 2962941-25-7 | FGFR-IN-13 (compound III-30) regulates signaling pathways mediated by endogenous FGFR1 (IC50=0.20±0.02 nM) and FGFR4 (IC50=0.40±0.03 nM) by inhibiting the expression of key proteins. |
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V88044 | FGFR-IN-14 | FGFR-IN-14 (compound 10h) is a pan-FGFR inhibitor. | |
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V104418 | FGFR-IN-15 | FGFR-IN-15 (compound 18i) is a pan-FGFR inhibitor with strong inhibitory activity against FGFR1-4. | |
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V104268 | FGFR-IN-16 | 2170748-42-0 | FGFR-IN-16 (Compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4 with IC50 of 8 nM, 4 nM, and 3.8 nM, respectively. |
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V78857 | FGFR-IN-9 | 3024090-08-9 | FGFR-IN-9 (Compound 19) is a potent, reversible, orally bioactive FGFR inhibitor (antagonist) with IC50s of 17.1, 29.6, 30.7, 46.7, and 64.3 nM for FGFR4WT, FGFR3, FGFR4V550L, FGFR2, and FGFR1, respectively. |
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V78963 | FGFR1 inhibitor 7 | FGFR1 inhibitor 7 (compound 5) is an inhibitor (blocker/antagonist) of FGFR1 tyrosine kinase with IC50 of 0.33 nM. | |
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V69473 | FGFR1 inhibitor-10 | 2426769-76-6 | FGFR1 inhibitor-10 (Compound 4i) is an FGFR1 inhibitor (IC50= 28 nM). |
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V88035 | FGFR1 inhibitor-11 | 2157482-40-9 | FGFR1 inhibitor-11 (compound 5g) binds to FGFR1 and inactivates its downstream ERK1/2 and IκBα/NF-κB signaling to inhibit RANKL-induced osteoclastogenesis. |
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V107797 | FGFR1 inhibitor-13 | 670266-26-9 | FGFR1 inhibitor-13 (Compound 1) is a FGFR1 inhibitor with IC50 of 4.2 μM. |
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V104738 | FGFR1 inhibitor-14 | 442534-83-0 | FGFR1 inhibitor-14 (Compound 28) is a FGFR1 inhibitor that can be used in anti-cancer research. |
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V69471 | FGFR1 inhibitor-2 | 2410612-08-5 | FGFR1 inhibitor-2 is an FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). |
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V79410 | FGFR1 inhibitor-8 | FGFR1 inhibitor-8 (Compound 9) is an FGFR1 inhibitor (IC50s: 0.5 nM). | |
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V79411 | FGFR1 inhibitor-9 | FGFR1 inhibitor-9 (Compound 9) is an FGFR1 inhibitor (IC50s: 0.85 nM). | |
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V31345 | FGFR1/DDR2 inhibitor 1 | 2308497-58-5 | FGFR1/DDR2 inhibitor 1 (compound 11k) is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively. |
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V79412 | FGFR1/VEGFR2-IN-1 | FGFR1/VEGFR2-IN-1 (compound 2b) is an FGFR1/VEGFR2 inhibitor. | |
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V88033 | FGFR2 degrader 1 | FGFR2 degrader 1 (compound 28E) is a selective degrader of FGFR2 with a DC50 of 0.645 nM. | |
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V69475 | FGFR2-IN-1 | 2677709-76-9 | FGFR2-IN-1 is a selective FGFR2 inhibitor (antagonist) with IC50 of 140 nM. |
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V69469 | FGFR2-IN-2 | 2677709-81-6 | FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor (antagonist) with IC50s of 389, 29 and 758 nM for FGFR1, FGFR2 and FGFR3 respectively. |
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