Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V77772 | Microtubule stabilizing agent-1 | Microtubule stabilizing agent-1 (compound 3l) is a paclitaxel analogue that can effectively promote tubulin polymerization. | |
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V5178 | MMAD | 203849-91-6 | MMAD (also known as Monomethyl auristatin D), anauristatin analog, is a novel and highly potent tubulin inhibitor/antimitotic agent that is often used as a warhead or a toxin payload in antibody drug conjugates (ADCs). |
|
V76759 | MMAD-d8 (Demethyldolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8) | MMAD-d8D is the deuterated form of MMAD. | |
|
V19682 | MMAF (Monomethyl auristatin F) | 745017-94-1 | Monomethyl auristatin F (also known as MMAF) is a highly potent tubulin/antimitotic inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. |
|
V32943 | MMAF Hydrochloride | 1415246-68-2 | Monomethyl auristatin F (MMAF) HCl is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. |
|
V32229 | MMAF sodium | 1799706-65-2 | Monomethyl auristatin F (MMAF) sodium is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. |
|
V80793 | MMAF-d8 (Monomethylauristatin F D8) | D8-MMAF HCl is the deuterated form of MMAF HCl. | |
|
V76758 | MMAF-d8 hydrochloride | MMAF-d8 (HCl)e is the deuterium labelled form of MMAF HCl. | |
|
V1887 | Monomethyl auristatin E (MMAE) | 474645-27-7 | Monomethyl auristatin E (also known as MMAE; SGD-1010), adolastatin 10 derivative, is a novel, synthetic and potent antimitotic/antitubulin agent which blocks the polymerization of tubulin,due to its high toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. |
C%3dC(O2)C3%3dCC%3dCC%3dC3CNC(%3dO)C4%3dCC5%3dC(N4)N%3dCS5)
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V51064 | MP-HJ-1b | MP-HJ-1b is a novel tubulin inhibitor. | |
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V85264 | MY-1442 | ||
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V26089 | Myoseverin | 267402-71-1 | Myoseverin is a reversible fission inducer of multinucleated myotubes into mononucleated fragments. |
|
V41112 | Neuroinflammatory-IN-3 | 1202404-23-6 | Neuroinflammatory-IN-3 is a tubulin inhibitor and an anti-neuroinflammatory agent. |
|
V26884 | Ombrabulin HCl | 253426-24-3 | Ombrabulin HCl (AV-E8062;AC-7700;AVE8062), an analogue of combretastatin A4 with improved water solubility, is a novel and potent tubulin inhibitor andvascular-disrupting agent with anticancer activity. |
|
V83678 | Oxaline | 55623-37-5 | |
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V55256 | P34cdc2 Kinase Fragment | 309247-52-7 | The P34cdc2 Kinase Fragment is associated with the integrity of DNA replication in yeast mitosis. |
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V84268 | PC5-VC-PAB-MMAE | 2922216-98-4 | |
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V4474 | PF-06380101 | 1436391-86-4 | PF-06380101 (Auristatin 0101; PF06380101; AUR-0101) is a novel and ultra-potent cytotoxic Dolastatin 10 analogue and a tubulin inhibitor with excellent anticancer activity. |
|
V76638 | PF-06380101-d8 (Aur0101-d8; Auristatin-0101-d8) | PF-06380101-d8 is the deuterium labelled form of PF-06380101. | |
|
V83232 | PM-534 | 2446376-25-4 | PM-534 is a novel and potent inhibitor of tubulin assembly. |
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