RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V53553 | Danofloxacin-d3 (Danofloxacin d3) | 1825377-28-3 | Danofloxacin-d3 is the deuterated form of Danofloxacin. |
|
V1476 | Daphnetin (7,8-dihydroxycoumarin) | 486-35-1 | Daphnetin (NSC-633563; NSC633563; 7,8-dihydroxycoumarin), a naturally occuring coumarin analog isolated from plants of the genus Daphne, is a PKI-protein kinase inhibitor with important biological activity (e.g. anti-inflammatory and anti-oxidant effects). |
|
V1453 | Daptomycin (LY146032) | 103060-53-3 | Daptomycin (also known as LY146032; LY-146032; trade name: Cubicin; Cidecin),a natural product isolated from the soil saprotroph Streptomyces roseosporus,is a novel lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
|
V2747 | Darusentan | 171714-84-4 | Darusentan (formerly LU-135252 or HMR-4005) is an endothelin receptor antagonist (ERA)/inhibitor. |
|
V4645 | Datelliptium chloride | 105118-14-7 | Datelliptium chloride, aellipticine derivative, is a novel and potent DNA-intercalating agent with anti-cancer activities. |
|
V21607 | Datelliptium chloride hydrochloride | 157000-76-5 | Datelliptium chloride hydrochloride is a DNA chimeric agent derived from Ellipticine (HY-15753). |
|
V86022 | ddCTP trilithium | 93939-77-6 | |
|
V80432 | ddTTP trisodium | ddTTP trisodium is a class of dideoxyribonucleotides (ddNTPs) that may be utilized in DNA sequencing as a DNA polymerase chain elongation inhibitor. | |
|
V75895 | Demycarosyl-3D-β-D-digitoxosylmithramycin SK | 1262896-48-9 | Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analogue with good anti-tumor activity. |
|
V54168 | DENV-IN-2 | 2253675-62-4 | DENV-IN-2 is a dengue viral replication inhibitor with an EC50 of 0.016 nM. |
|
V75893 | DENV-IN-6 | 2375780-95-1 | DENV-IN-6 is a potent inhibitor of DENV (I-IV) with EC50s of 17.5, 13.20, 6.8 and 11.41 μM for inhibiting DENV (I-IV) replication. |
|
V52187 | DENV-IN-7 | 2499537-22-1 | DENV-IN-7 is a flavonoid analogue and a dengue virus (DENV) inhibitor with an EC50 value of 70 nM. |
|
V53207 | Deoxyguanosine triphosphate trisodium salt (dGTP trisodium salt; 2'-Deoxyguanosine-5'-triphosphate trisodium salt) | 93919-41-6 | Deoxyguanosine triphosphate (dGTP) trisodium salt is a nucleotide precursor used in DNA synthesis in cells. |
|
V85178 | DHODH-IN-24 | 418775-30-1 | |
|
V55117 | DHPS-IN-1 | 2643300-54-1 | DHPS-IN-1 has the best DHPS inhibitory potency (IC50 = 0.014 μM) and excellent inhibitory activity against melanoma cells. |
|
V84128 | DHX9-IN-10 | 2973746-79-9 | |
|
V84129 | DHX9-IN-11 | 2973402-91-2 | |
|
V84127 | DHX9-IN-12 | 2973747-13-4 | |
|
V84125 | DHX9-IN-13 | 2973399-28-7 | |
|
V84143 | DHX9-IN-14 | 2973747-90-7 |
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