RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1435 | BMH-21 | 896705-16-1 | BMH-21 (BMH 21; BMH21) is a novel and potent DNA intercalator with potential antineoplastic activity. |
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V2335 | Bractoppin | 2290527-07-8 | Bractoppin is a potent and selective inhibitor of phosphopeptide recognition by the BRCA1 tBRCT domain, which selectively interrupts BRCA1 tBRCT-dependent signals evoked by DNA damage. |
|
V46895 | Branaplam diHCl | 1562338-39-9 | Branaplam diHCl (LMI-070 dihydrochloride; NVS-SM1) is a potent, orally bioactive, small-molecule enhancer of SMN2 (survival of motor neuron-2) splicing that elevates full-length SMN protein and extends survival in a severe SMA mouse model. |
|
V88760 | BRC4 peptide | BRC4 peptide is a specific peptide in BRCA2 protein, which interacts with RAD51 protein to help repair broken DNA chains. | |
|
V34685 | Bromochloroacetonitrile (bromochloroacetonitrile) | 83463-62-1 | Bromochloroacetonitrile is a byproduct of water treated with chlorine that contains organic matter. |
|
V2277 | Brr2 inhibitor C9 | 2104030-82-0 | Brr2 inhibitor C9 (no formal name but also known as Brr2 Inhibitor 9 ) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. |
|
V54316 | BVDU 5′-Triphosphate ((E)-5-(2-Bromovinyl)-dUTP; BVdUTP) | 77222-61-8 | BVDU 5′-Triphosphate is a 5′-Triphosphate tagged antiviral agent that targets the viral DNA polymerase. |
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V52309 | BVDV-IN-1 | 345651-04-9 | BVDV-IN-1 is a bovine viral diarrhea virus (BVDV) non-nucleoside inhibitor (NNI) with an EC50 value of 1.8 μM. |
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V102236 | BW 348U87 | 127142-14-7 | BW 348U87 is a ribonucleotide reductase inhibitor that acts synergistically with acyclovir and enhances the antiviral activity of acyclovir against herpes simplex virus (HSV) in an athymic nude mouse model. |
|
V55194 | Bz-rC Phosphoramidite | 118380-84-0 | Bz-rC Phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation of oligonucleotides. |
|
V101833 | Caf1-IN-1 | 1807775-88-7 | Caf1-IN-1 (Compound 8j) is an inhibitor of ribonuclease Caf1 with IC50 of 0.59 µM. |
|
V52787 | Carbazole-d8 (carbazole-d8) | 38537-24-5 | Carbazole-d8 is the deuterated form of Carbazole (HY-D0204). |
|
V106936 | CB096 | 108883-90-5 | CB096 binds to the 5′CGG/3′GGC internal loop structure of r(G4C2)exp RNA and interferes with its gain-of-function mechanism, thereby regulating nucleolar focusing, RNA splicing defects, RNA metabolism, nucleocytoplasmic transport dysfunction, and toxic dipeptide repeats (DPRs) produced by RNA translation. |
|
V52292 | ccc_R08 | 2919019-72-8 | ccc_R08 is a non-cytotoxic, oral cccDNA inhibitor that decreases the amount of cccDNA in HBV-infected mice's livers. |
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V103332 | CCT239065 | 1163719-51-4 | CCT239065 is an oral, potent, mutant protein kinase V600EBRAF (RAF) inhibitor with antitumor activity. |
|
V17878 | CeMMEC13 | 1790895-25-8 | CeMMEC13 is a selective inhibitor of TAF1. |
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V78776 | Chrexanthomycin C | Chrexanthomycin C is a marine naturally occurring compound with significant bioactivity and is orally bioavailable. | |
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V103973 | Clofarabine-5'-diphosphate | 167620-89-5 | Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite of clofarabine phosphorylated by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate can be further phosphorylated to clofarabine-5'-triphosphate, which produces cytotoxicity to cancer cells by inhibiting DNA synthesis and DNA repair. |
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V103974 | Clofarabine-5'-diphosphate trisodium | Clofarabine-5'-diphosphate trisodium (Clofarabine-DP trisodium) is the sodium salt form of clofarabine-5'-diphosphate. | |
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V103975 | Clofarabine-5'-triphosphate trisodium | Clofarabine-5'-triphosphate trisodium is the sodium salt form of clofarabine-5'-triphosphate. |
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