5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71170 | SGS518oxalate | 445441-27-0 | SGS518 oxalate is a selective 5-HT6R antagonist. |
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V71175 | SR 57227A | 77145-61-0 | SR 57227A is an orally bioactive selective agonist of the 5-HT3 receptor that penetrates the BBB (blood-brain barrier). |
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V71148 | ST1936 | 1210-81-7 | ST1936 is a selective nanomolar affinity 5-HT6 receptor agonist/activator with Kis of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors respectively. |
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V71177 | Strictosidinic acid | 150148-81-5 | Strictosidinic acid is an orally bioactive glycoside indole monoterpene alkaloid extracted from the leaves of Psychotria myriantha, which inhibits the precursor enzymes of 5-HT biosynthesis and reduces 5-HT content. |
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V0988 | Sumatriptan Succinate (GR43175) | 103628-48-4 | Sumatriptan Succinate (GR-43175; GR43175; Sumatran; Sumax), an approved triptan sulfa drug and a sulfonamide compound, is a selective 5-HT1 receptor agonist used for the treatment of migraine headaches. |
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V28980 | Tandospirone (SM3997) | 87760-53-0 | Tandospirone (SM-3997) is a novel, highly potent and selective 5-HT1A receptor partial agonist with Ki of 27 nM, and exhibits selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Kis ranging from 1300-41000 nM). |
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V33822 | Tandospirone citrate (SM 3997) | 112457-95-1 | andospirone citrate (SM-3997) is a novel, highly potent and selective 5-HT1A receptor partial agonist with Ki of 27 nM, and exhibits selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Kis ranging from 1300-41000 nM). |
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V71146 | TCB2 | 912342-28-0 | TCB2 is an agonist of the serotonin 2A receptor (5-HT2A). |
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V3017 | TG6-10-1 | 1415716-58-3 | TG6-10-1 is a cell-permeable, highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2) with Kb of 17.8 nM. |
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V0967 | Tianeptine sodium | 30123-17-2 | Tianeptine sodium (Stablon, Coaxil, Tianeurax, Tatinol,Salymbra), the sodium salt of tianeptine and an atypical antidepressant, is a potent and selective serotonin reuptake enhancer (SSRE) used primarily for the treatment of major depressive disorders. |
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V0986 | Trazodone HCl (AF-116;, KB-831) | 25332-39-2 | Trazodone HCl (Beneficat, KB 831, KB831, AF 1161, AF1161), the hydrochloride salt of Trazodone, is an approved antidepressant drug of the class of serotonin receptor antagonists and reuptake inhibitors (SARI) with the potential for treatment of anxiety disorders. |
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V28890 | Tropisetron (SDZ-ICS-930) | 89565-68-4 | Tropisetron (also known as ICS 205-930)is a novel,potent and selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist, used to treat nausea and vomiting following chemotherapy. |
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V1035 | Tropisetron HCl (SDZ-ICS-930 HCl) | 105826-92-4 | Tropisetron HCl (Navoban; ICS-205930; ICS 205-930), the hydrochloride salt of Tropisetron which is an anti-emetic drug, is a novel, potent and selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist that has been approved for the treatment of chemotherapy-induced nausea and vomiting. |
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V71139 | U92016A hydrochloride | 149654-41-1 | U92016A HCl is a metabolically stable, orally bioactive 5-HT1A receptor agonist/activator with extremely high intrinsic activity. |
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V71193 | UCSF686 | 2248852-19-7 | UCSF686 is a probe to study the function of 5-HT5AR. |
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V1025 | Urapidil HCl | 64887-14-5 | Urapidil HCl, the hydrochloride salt of uradipil which is a sympatholytic antihypertensive drug, is potent α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. |
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V71189 | Urapidil-d3 (Urapidil d3) | 1398066-08-4 | Urapidil-d3 is the deuterium labelled form of Urapidil. |
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V71164 | Usmarapride (SUVN-D4010) | 1428862-33-2 | Usmarapride (SUVN-D4010) is a specific, orally bioactive and BBB (blood-brain barrier) permeable (penetrable) 5-HT4 receptor partial agonist (EC50=nM). |
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V1024 | Venlafaxine HCl (Wy 45030 HCl) | 99300-78-4 | Venlafaxine (Wy45030; Wy-45030; Effexor, Effexor XR, Lanvexin, Viepax, and Trevilor) is an arylalkanolamine-based antidepressant that has been approved for use. |
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V32437 | Vilazodone (EMD 68843) | 163521-12-8 | Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
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