5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71198 | 5-HT2A receptor agonist-3 | 1391499-52-7 | 5-HT2A receptor agonist-3 is the most selective human 5-HT2A receptor agonist discovered so far, with a Ki of 2.5 nM. |
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V71218 | 5-HT2A&5-HT2C agonist-1 | 1640-02-4 | 5-HT2A&5-HT2C agonist-1 (Example 2) is a 5-HT2A and 5-HT2C agonist/activator with IC50 of 196 nM and 0.9 nM respectively. |
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V71186 | 5-HT2agonist-1 | 2708279-78-9 | 5-HT2 agonist-1 (Compound 24) is a 5-HT2A, 5-HT2B, and 5-HT2C agonist/activator with IC50s of 10 nM, 8.3, and 1.6 nM, respectively. |
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V71201 | 5-HT2C agonist-3 | 2104810-18-4 | 5-HT2C agonist-3 ((+)-19) is a selective 5-HT2C agonist (EC50= 24 nM, Ki: 78 nM). |
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V71224 | 5-HT2C agonist-3 free base | 2104810-17-3 | 5-HT2C agonist-3 ((+)-19) free base is a selective 5-HT2C agonist (EC50= 24 nM, Ki: 78 nM). |
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V85384 | 5-HT2CR agonist 1 | 1216074-15-5 | |
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V80054 | 5-HT6 agonist 1 | 5-HT6 agonist 1 (Compound 19) is a 5-HT6 agonist (Ki: 5 nM). | |
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V71156 | 5-HT6/5-HT2AR antagonist-1 | 2763654-60-8 | 5-HT6/5-HT2AR antagonist-1 is a potent dual 5-HT6/5-HT2AR antagonist (inhibitor) with Kis of 11 nM and 39 nM, respectively. |
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V80053 | 5-HT6R antagonist 1 | 5-HT6R antagonist 1 (Comopund 8) is a 5-HT6R antagonist (Ki: 5 nM). | |
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V85046 | 5-HT6R antagonist 3 | ||
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V71223 | 7-Desmethyl-agomelatine-d3 (7-desmethyl agomelatine impurity 5-d3) | 2749427-92-5 | 7-Desmethyl-agomelatine-d3 is the deuterium labelled form of 7-Desmethyl-agomelatine. |
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V2790 | 8-OH-DPAT | 78950-78-4 | 8-OH-DPAT (also known as 8-Hydroxy-DPAT) is a classic, potent and selective agonist of 5-HT1A with the potential to be used for sleep disorders. |
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V0974 | Agomelatine (S-20098; BAN, rINN; Valdoxan, Melitor, Thymanax) | 138112-76-2 | Agomelatine (S20098; AGO-178; S-20098; AGO178; Valdoxan, Melitor, Thymanax) is a potent and specific agonist of MT1 and MT2 receptors with anti-depressive activity. |
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V86141 | Almotriptan hydrochloride | 154323-46-3 | |
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V1027 | Almotriptan Malate (LAS 31416) | 181183-52-8 | Almotriptan Malate (formerly LAS31416; LAS-31416; Almogran; Amignul; Almotrex; Axert), the maleate salt of Almotriptan which is an approved anti-migraine drug, is a potent and selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist. |
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V33099 | Alprenolol | 13655-52-2 | Alprenolol (alfeprol, alpheprol) is a potent and non-selective beta blocker as well as 5-HT1A receptor antagonist, used in the treatment of angina pectoris. |
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V71119 | Alverine citrate (NSC 35459) | 5560-59-8 | Alverine citrate is an antagonist of the 5-HT1A receptor with IC50 of 101 nM. |
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V79060 | AM9405 | AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. | |
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V0992 | Amitriptyline HCl (Elavil) | 549-18-8 | Amitriptyline (Elavil; Tryptanol; Amitriptylin; Damilen; Triptanol),a tricyclic antidepressant (TCA), is an inhibitor of serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with potential anti-depressive activity. |
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V85420 | Ampreloxetine TFA (TD-9855 TFA) | 1227056-85-0 |
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