5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71205 | 4-Butyl-alpha-agarofuran (Buagafuran; Buagarofuran) | 272126-07-5 | 4-Butyl-alpha-agarofuran (AF 5) is an anxiolytic and antidepressant. |
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V102639 | 4-CAB hydrochloride | 23292-08-2 | 4-CAB hydrochloride is an analog of p-chloroamphetamine and a psychoactive compound that inhibits the reuptake of serotonin (IC50 = 330 nM) and dopamine (IC50 = 2.3 μM). |
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V102931 | 4-Chloromethamphetamine hydrochloride | 30572-91-9 | 4-Chloromethylamphetamine hydrochloride is a new psychoactive substance of the propylamine class. |
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V106868 | 4-fluoro MBZP | 144734-44-1 | 4-FluoroMBZP is a new psychoactive substance belonging to the phenylpiperazine class of compounds that can be used to study the 5-HT2 receptors of the central nervous system. |
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V102794 | 4-hydroxy DiPT hydrochloride | 63065-90-7 | 4-HydroxyDiPT hydrochloride is a 5-HT2A agonist that induces head twitch response (HTR) in mice and exhibits psychoactive effects. |
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V102725 | 4-Hydroxy MET | 77872-41-4 | 4-HydroxyMET (4-HO-MET) is a psychoactive substance of the tryptamine class (NPS) and belongs to the structural type of the endogenous neurotransmitter serotonin. |
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V104954 | 4-Hydroxy MPT | 763035-03-6 | 4-HydroxyMPT (4-OH-MPT) is a serotonergic psychoactive substance and 5-HT2A and 5-HT2B receptor agonist with EC50 values of 3.82 nM and 3.4 nM, respectively. |
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V103000 | 4-Iodoamphetamine hydrochloride | 21894-58-6 | 4-Iodoamphetamine (p-iodoamphetamine) hydrochloride is a halogenated amphetamine characterized by an iodine atom at the para-position of the phenyl group, which selectively induces the release of serotonin and inhibits its reuptake in rat brain synaptosomes. |
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V107137 | 4-Methylamphetamine hydrochloride | 41632-56-8 | 4-Methamphetamine hydrochloride is a 5-HT1A receptor agonist, which can cause a decrease in body temperature in rats by binding to the 5-HT1A receptor. |
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V71151 | 4F 4PP oxalate | 144734-36-1 | 4F 4PP (oxalate) is a selective 5-HT2A antagonist (inhibitor) with almost as high affinity as ketotryptamine (Ki= 5.3 nM) but much lower affinity for the 5-HT2C site (Ki= 620 nM ). |
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V71140 | 5-Carboxamidotryptamine (5-CT) | 74885-09-9 | 5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist. |
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V71125 | 5-Carboxamidotryptamine maleate (5-CT maleate) | 74885-72-6 | 5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptor agonist (activator). |
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V104697 | 5-Chloro-α-methyltryptamine | 712-07-2 | 5-Chloro-α-methyltryptamine (compound 7b) is a potent and selective dual DA/5-HT releaser and 5-HT2a agonist. |
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V107354 | 5-Fluoro-α-methyltryptamine hydrochloride | 776-56-7 | 5-Fluoro-α-methyltryptamine hydrochloride can lead to an increase in intracellular 5-HT levels, thereby increasing the release of 5-HT. |
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V103738 | 5-HT/NA Reuptake inhibitor-1 | 844882-78-6 | 5-HT/NA reuptake inhibitor-1 (Compound 9) is a selective dual 5-HT and NA reuptake inhibitor with IC50 of 660 nM and 70 nM, respectively. |
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V71178 | 5-HT1A modulator 2 hydrochloride | 3880-76-0 | 5-HT1A modulator 2 HCl is an analogue of 8-OH-DPAT. |
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V101604 | 5-HT1AR agonist 1 | 5-HT1AR agonist 1 (compound A3) exhibited a relatively balanced multi-target activity profile, including 5-HT1AR agonist (EC50 = 34 nM), SERT reuptake inhibitor (IC50 = 12 nM), NET reuptake inhibitor (IC50 = 78 nM), and DAT reuptake inhibitor (IC50 = 135 nM). | |
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V104647 | 5-HT1AR agonist 2 | 5-HT1AR agonist 2 (Compound 4f) is a 5-HT1A receptor agonist (Ki: 10.0 nM). | |
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V71194 | 5-HT2 agonist-1 free base | 2708279-77-8 | 5-HT2 agonist-1 (Compound 24) free base is a 5-HT2A, 5-HT2B and 5-HT2C agonist/activator with IC50 of 10 nM, 8.3, and 1.6 nM respectively. |
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V84412 | 5-HT2A agonist 2 |
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