5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V28782 | Ansofaxine hydrochloride ( LY03005; LPM570065) | 916918-84-8 | Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 of 723, 491 and 763 nM, respectively. |
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V79367 | Antipsychotic agent-2 | Antipsychotic agent-2 (Compound 11) is a potent antipsychotic agent. | |
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V71184 | Aripiprazole (1,1,2,2,3,3,4,4-d8) (Aripiprazole (1,1,2,2,3,3,4,4-d8)) | 1089115-04-7 | Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterated form of Aripiprazole. |
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V0991 | Aripiprazole (OPC-14597) | 129722-12-9 | Aripiprazole (formerly OPC-14597; OPC 14597; OPC14597; trade name Abilify) is an approved atypical antipsychotic drug that acts as a high-affinity partial agonist of 5-HT receptor. |
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V33946 | Aripiprazole D8 | 1089115-06-9 | Aripiprazole D8 is the octa-deuterated form of Aripiprazole (OPC-14597; trade name Abilify) which is a 5-HT1A receptor partial agonist (Ki = 4.2 nM) and an approved atypical antipsychotic drug. |
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V11591 | Aripiprazole monohydrate (OPC14597) | 851220-85-4 | ripiprazole monohydrate (formerly also known as OPC-14597; OPC31; Abilitat), the monohydrated form of Aripiprazole, is a novel atypical antipsychotic drug that is reported to be a high-affinity 5-HT receptor partial agonist. |
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V11689 | Asenapine (Org 5222) | 65576-45-6 | Asenapine (Org5222; Org-5222; HSDB-8061; HSDB8061; Saphris and Sycrest),an atypical antipsychotic, is a potent and high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors. |
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V32953 | Asenapine HCl (Org 5222 HCl) | 1412458-61-7 | Asenapine HCl (Org-5222; HSDB 8061; Saphris; Sycrest) is a potent antagonist of multiple targets including serotonin, norepinephrine, dopamine and histamine receptors. |
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V1023 | Atomoxetine HCl (Tomoxetine; LY 139603) | 82248-59-7 | Atomoxetine HCl (formerly LY139603; LY-139603; Tomoxetine; Strattera; Tomoxetina; Tomoxetinum), the hydrochloride salt of Atomoxetine, is a potent and selective norepinephrine (NE) transporter/reuptate inhibitor that has been used for treating attention-deficit hyperactivity disorder (ADHD). |
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V2807 | AVN-492 | 1220646-23-0 | AVN-492 is a highly specific, selective and orally bioavailable antagonist of the 5-HT6R with Kiof 91 pM. |
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V1000 | Azasetron HCl (Y-25130) | 123040-16-4 | Azasetron HCl (formerly Y 25130 HCl; Y-25130; Y25130), an approved antiemetic drug, is a potent and selective antagonist of 5-HT3 receptor with an IC50 of 0.33 nM. |
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V71126 | Befiradol hydrochloride (NLX-112 hydrochloride; F 13640 hydrochloride) | 2436760-81-3 | Befiradol HCl (NLX-112 HCl) is a selective serotonin 1A (5-HT)1A receptor agonist (activator). |
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V71166 | BIMU 8 | 134296-40-5 | BIMU 8 is a potent and specific 5-HT4 agonist/activator with EC50s of 18 nM, 77 nM and 540 nM for the wild-type 5HT4 receptor, T3.36A and W6.48A mutant 5-HT4 receptors. |
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V1021 | Blonanserin (AD-5423) | 132810-10-7 | Blonanserin (formerly AD 5423; AD-5423; AD5423)is anatypical antipsychotic agent acting as arelatively selective serotonin (5-HT) 2A and dopamine D2 antagonist with the potential to be used for the treatment of schizophrenia. |
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V71158 | Blonanserin-d5 (AD-5423-d5) | 1346599-86-7 | Blonanserin-d5 is the deuterium labelled form of Blonanserin. |
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V0987 | BMY 7378 | 21102-95-4 | BMY 7378 (BMY-7378; BMY7378) is a multi-target compound that inhibits α2C-adrenoceptor and α1D-adrenoceptor with pKi values of 6.54 and 8.2, respectively. |
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V71354 | Bopindolol fumarate (bopindolol fumarate; (±)-Bopindolol fumarate) | 79125-22-7 | Bopindolol ((±)-Bopindolol) fumarate is an orally bioactive beta-adrenoceptor (ARs) antagonist (inhibitor) with partial agonist activity. |
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V71130 | Brexpiprazole S-oxide-d8 (DM-3411 d8) | 2748605-29-8 | Brexpiprazole S-oxide-d8 is the deuterated form of Brexpiprazole S-oxide. |
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V0978 | BRL-15572 dihydrochloride | 193611-72-2 | BRL-15572 (BRL-15,572; BRL-15572; BRL 15,572; BRL15,572) dihydrochloride salt is a potent and selective 5-HT1D receptor antagonist with important biological activity. |
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V71135 | BRL-15572 hydrochloride | 1173022-77-9 | BRL-15572 HCl is a selective antagonist of h5-HT1D and shows high affinity for the h5-HT1D receptor. |
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