In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71770 | Cyclo(glycyl-L-leucyl) (Cyclo(glycyl-L-leucyl); Cyclo(leu-gly)) | 5845-67-0 | Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)) is a neuropeptide that downregulates dopamine (DA) receptors and attenuates dopaminergic hypersensitivity. |
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V71754 | D4R antagonis-2 | 2846077-70-9 | D4R antagonist-2 is a potent and specific D4R antagonist (inhibitor) with IC50 of 6.87 µM. |
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V71739 | D4R antagonist-1 | 2846077-19-6 | D4R antagonist-1 is a potent and specific D4R antagonist (inhibitor) with IC50 of 6.87 µM. |
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V71771 | D4Ragonist-1 | 2826198-44-9 | D4R agonist-1 (Compound 16f) is a D4R partial agonist (Ki: 2.2 nM). |
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V4976 | Dexpramipexole HCl ((R)-Pramipexole HCl) | 104632-27-1 | Dexpramipexole (also known as KNS-760704,R-(+)-Pramipexole and (R)-Pramipexole), an enantiomer of pramipexole, is a dopamine agonist of the non-ergoline class with the potential for the treatment of amyotrophic lateral sclerosis (ALS) (also known as Lou Gehrig’s disease). |
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V1262 | Domperidone (R33812) | 57808-66-9 | Domperidone (R 33812; R-33812; KW5338; KW-5338; Motilium; Domperidona) is an orally bioactive dopamine D2 receptor antagonist and an antiemetic medication used to relieve nausea and vomiting. |
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V71763 | Domperidone-d6 (Domperidone d6) | 1329614-18-7 | Domperidone-d6 is the deuterated form of Domperidone. |
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V71766 | Dopamine D2 receptor agonist-2 | 1610591-93-9 | Dopamine D2 receptor agonist-2 (compound 36) is a potent partial agonist ligand of dopamine D2 receptor (D2 receptor) with Ki of 11.2 nM. |
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V71748 | Dopamine D3 receptor ligand-1 | 2882828-93-3 | Dopamine D3 receptor ligand is a specific and high-affinity dopamine D3 receptor ligand, which is 89 times more selective for D3 than D2 (D3 Ki=8 nM, D2 Ki= 715 nM). |
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V71774 | Dopamine D3 receptor ligand-2 | 2882828-95-5 | Dopamine D3 receptor ligand-2 (compound 8) is a potent D3 receptor ligand with a Ki of 11.4 nM. |
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V71755 | Dopamine D3 receptor ligand-3 | 2891605-81-3 | Dopamine D3 receptor ligand-3 (compound 12C) is a potent D3 receptor ligand with a Ki of 3.6 nM. |
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V84158 | Dopamine D4 receptor ligand 2 | 219125-63-0 | |
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V1269 | Dopamine HCl | 62-31-7 | Dopamine HCl (formerly Intropin; Dopamine HCl; ASL 279; ASL279; P 498; 3-Hydroxytyramine, ASL-279 and Intropin), the hydrochloride salt of dopamine, is an endogenous catecholamine neurotransmitter found in a wide variety of animals, it is a dopamine D1-5 receptors agonist. |
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V20255 | Droperidol | 548-73-2 | Droperidol (Dridol; Properidol; Dehydrobenzperidol; Inapsine) is a novel and potent D1DR and D2DR inhibitor with anti-emetic, sedative and anti-anxiety activities.It is also an antidopaminergic drug that can be used as an antiemetic and antipsychotic. |
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V71176 | Ecopipam hydrobromide (SCH 39166 hydrobromide) | 2587360-22-1 | Ecopipam (SCH 39166) HBr is a specific, orally bioactive dopamine D1/D5 receptor antagonist (inhibitor) with Kis of 1.2 nM and 2.0 nM, respectively. |
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V9611 | Eticlopride HCl | 97612-24-3 | Eticlopride HCl (FLB131; FLB-131) is a potent antipsychotic agent acting asa selective dopamine D2‐like receptor antagonist. |
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V85397 | Fallypride | 166173-78-0 | |
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v2450 | FAUC-346 | 474432-65-0 | FAUC 346 is a selective D3 partial agonist (EC50 = 1.5 nM). |
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V20937 | FAUC-365 | 474432-66-1 | FAUC-365 (FAUC365) is a novel, potent and selective dopamine D3 receptor antagonist with the potential to be used for the treatment of schizophrenia, and Parkinsons disease. |
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V29688 | Fenoldopam (SKF 82526) | 67227-56-9 | Fenoldopam (SKF-82526) is a synthetic benzazepine analog acting as a selective D1 receptor partial agonist. |
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