In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71729 | GBR 12783 dihydrochloride | 67469-75-4 | GBR 12783 di-HCl is a specific, potent and specific dopamine uptake inhibitor that can suppress the uptake of [3H]dopamine ([3H]dopamine) by striatal synaptosomes in rats and mice, with IC50 of 1.8 nM and 1.2 nM. |
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V71767 | GBR-12879 dihydrochloride | 67469-45-8 | GBR-12879 diHCl is a potent dopamine uptake inhibitor. |
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V99968 | Glovadalenum | 2576359-31-2 | Glovadalenum (Glovadalen) is a dopamine D1 receptor positive allosteric modulator. |
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V2454 | GR 103691 | 162408-66-4 | GR 103691 is a potent and specific dopamine D3 receptor blocker (antagonist) with Ki of 0.4 nM. |
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V71717 | GSK598809 | 863680-45-9 | GSK598809 is a selective antagonist of dopamine D3 receptor (DRD3) with pKi of 8.9. |
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V71742 | Haloperidol-d4 N-Oxide (haloperidol d4 (N-oxide)) | 1246815-56-4 | Haloperidol-d4 N-Oxide is the deuterium labelled form of Haloperidol. |
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V22774 | ITI-722 (Lumateperone) | 313368-91-1 | Lumateperone (ITI-722; ITI722; Caplyta) is a novel, potent, first-in-class and dual 5HT2A receptor antagonist and dopamine receptor phosphoprotein modulator (DPPM). |
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V71776 | JHW007 hydrochloride | 202645-74-7 | JHW007 HCl is the HCl of JHW007. |
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V101770 | KEMPFPKYPVEP | 1393589-51-9 | KEMPFPKYPVEP is a neuropeptide composed of 12 amino acids. |
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V94042 | LB-102 | 2227154-23-4 | LB-102 is an oral dopamine D2, D3, and 5-HT7 receptor inhibitor that can be used in the research of schizophrenia and other psychiatric disorders. |
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V71153 | LE 300 | 274694-98-3 | LE 300 is a potent and specific dopamine D1-like receptor antagonist (inhibitor) with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. |
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V99973 | Matsupexolum | 1399442-97-7 | Matsupexolum (Matsupexole) is a dopamine receptor agonist. |
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V71737 | Mesdopetam (IRL790) | 1403894-72-3 | Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM) with psychomotor stabilizing properties. |
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V71725 | Mesdopetam hemitartrate (IRL790 hemitartrate) | 2562346-14-7 | Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM) with psychomotor stabilizing properties. |
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V89037 | MeSeI | 2901664-87-5 | MeSeI exhibits weak inhibitory activity against monoamine oxidase MAO-A and MAO-B (IC50=198.8 µM). |
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V84639 | Mesulergine hydrochloride (CU32-085 hydrochloride) | 72786-12-0 | Mesulergine (CU32-085) hydrochloride is a potent 5-HT2C antagonist and dopamine (DA) agonist. |
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V71731 | MIF-1 TFA (Pro-Leu-Gly-NH2 TFA; Melanostatin TFA) | 35240-69-8 | MIF-1 TFA (Melanostatin) is an endogenous brain peptide and a potent allosteric modulator of dopamine receptors. |
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V37653 | ML417 | 1386162-69-1 | ML417 is a novel and selective agonist of D3 dopamine receptor, it potently promotes D3R-mediated β-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors. |
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V107743 | Moperone | 1050-79-9 | Moperone (R 1658) is a D2 dopamine receptor and D3 dopamine receptor antagonist with IC50 of 1.0 nM and 1.0 nM, respectively. |
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V2705 | MPTP hydrochloride | 23007-85-4 | MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. |
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