In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V22058 | Haloperidol | 52-86-8 | Haloperidol (R1625; Eukystol; HSDB-3093; Haldol; Serenace; Aloperidin) is a potent antipsychotic medication acting as adopamine D2 receptor antagonist. |
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V8563 | Fluoroclebopride | 154540-49-5 | Fluoroclebopride is useful chemical for PET image study. |
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V20255 | Droperidol | 548-73-2 | Droperidol (Dridol; Properidol; Dehydrobenzperidol; Inapsine) is a novel and potent D1DR and D2DR inhibitor with anti-emetic, sedative and anti-anxiety activities.It is also an antidopaminergic drug that can be used as an antiemetic and antipsychotic. |
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V11154 | Amisulpride HCl | 81342-13-4 | Amisulpride HCl (Barhemsys; Solian; Amazeo; Aminosultopride; Amipride; Amival; Deniban; Amisulprida; Soltus; DAN-2163; Sulpitac; Sulprix), the hydrochloride salt of Amisulpride, is an atypical antipsychotic medication approved for treating psychosis in schizophrenia and episodes of mania in bipolar disorders. |
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V1259 | Chlorprothixene | 113-59-7 | Chlorprothixene (Paxyl; Rentovet; Truxal; Ro 4-0403; N-714; MK-184; Taractan; Tarasan), an typical antipsychotic drug of the thioxanthene class, is an antagonist of dopamine and histamine receptors with potential antipsychotic, sedative and antiemetic activity. |
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V9293 | Clozapine N-oxide | 34233-69-7 | Clozapine N-oxide is a major metabolite of Clozapine and an agonist of human designer muscarinic receptors (DREADDs). |
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V17137 | Bromperidol (Impromen; R-11333) | 10457-90-6 | Bromperidol (Impromen; R11333),a butyrophenone derivative, is potent and long-term maintenance treatment for schizophrenia. |
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V1268 | Pergolide Mesylate (LY127809) | 66104-23-2 | Pergolide Mesylate (Permax; Pergotoliderived; LY127809; LY-127809), the mesylate salt of Pergolide, is a novel and potent antiparkinsonian agent which acts as a dopaminergic agonist. |
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V17086 | Bromocriptine Mesylate (CB-154) | 22260-51-1 | Bromocriptine Mesylate(CB154) is a dopamine D2/3 agonist (with pKi of 8.05±0.2 for D2) for the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes. |
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V1248 | Benztropine mesylate | 132-17-2 | Benztropine mesylate (NSC-42199; ST-50997629; NSC 42199; ST 50997629; Cogentin; MLS000737056), the mesilate salt of Benztropine, is a highly potent dopamine transporter (DAT) inhibitor used for the treatment of symptoms of Parkinson's disease such as involuntary tremor and dystonia. |
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V9611 | Eticlopride HCl | 97612-24-3 | Eticlopride HCl (FLB131; FLB-131) is a potent antipsychotic agent acting asa selective dopamine D2‐like receptor antagonist. |
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V1247 | Tetracaine HCl | 136-47-0 | Tetracaine HCl (also called Amethocalne; Butylocaine; Curtacain; Decicain; Gingicain; PantocaineM; Intercaine; Leocaine; Menonasal; Niphanoid), thehydrochloride salt form of tetracaine, is a local anaesthetic and a channel function allosteric inhibitor. |
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V2902 | Cariprazine HCl | 1083076-69-0 | Cariprazine HCl(formerly MP-214; RGH-188; MP214; RGH188; Vraylar; Reagila), thehydrochloride salt of cariprazine, is an antipsychotic medication that has been approved for the treatment of schizophrenia, as well as for bipolar disorder (manic/mixed and depressive episodes), and as an adjunctive agent for the treatment of major depressive disorder. |
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V1269 | Dopamine HCl | 62-31-7 | Dopamine HCl (formerly Intropin; Dopamine HCl; ASL 279; ASL279; P 498; 3-Hydroxytyramine, ASL-279 and Intropin), the hydrochloride salt of dopamine, is an endogenous catecholamine neurotransmitter found in a wide variety of animals, it is a dopamine D1-5 receptors agonist. |
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V1250 | Amfebutamone HCl | 31677-93-7 | Amfebutamone HCl (Bupropion, Wellbutrin, Zyban; BW-323; NSC315851; NSC-315851), the hydrochloride salt of Amfebutamone, is a potent and selective norepinephrine-dopamine reuptake inhibitor used as an antidepressant and for smoking cessation. |
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V60107 | Tetrahydropalmatine hydrochloride | 6024-85-7 | Tetrahydropalmatine (also known as DL-Tetrahydropalmatine) hydrochloride has analgesic properties. Tetrahydropalmatine hydrochloride prevents a rat epileptic seizure by blocking the release of dopamine from amygdaloid. |
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V1261 | Pramipexole 2HCl Monohydrate | 191217-81-9 | Pramipexole 2HCl monohydrate (formerly known as SND 919; (S)-Pramipexole; trade name Mirapex among others) is the dihydrochloride salt and hydrated form of of pramipexole which isa potent agonist of the Gαi-linked dopamine receptors D2, D3, and D4 with neuroprotective effects. |
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V28566 | Pramipexole 2HCl ((S)-Pramipexole HCl) | 104632-25-9 | Pramipexole 2HCl (also known as SND 919; (S)-Pramipexole HC), an agonist of the Gαi-linked dopamine receptors D2, D3, and D4, is a potent dopamine agonist of the non-ergoline class that is used for the treatment of Parkinsons disease (PD) and restless legs syndrome (RLS). |
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V2067 | Trimethobenzamide HCl (Ro 2-9578) | 554-92-7 | rimethobenzamide (also known as Ro 2-9578; trade names Tebamide, Tigan), a blocker of the D2 receptor, is a potent antiemetic that is used to prevent nausea and vomiting. |
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V21149 | Fluphenazine HCl | 146-56-5 | FluphenazineHCl, the hydrochloride salt of Fluphenazine, is a novel and potent antipsychotic agent acting as adopamine D2 receptor inhibitor. |