The G protein-coupled receptor family, which includes the glucagon receptor (GCGR), is crucial for regulating blood sugar levels. The class B G-protein coupled family of receptors includes the glucagon receptor, a 62 kDa protein that is activated by glucagon and coupled to G alpha i, Gs, and to a lesser extent G alpha q. Adenylate cyclase is activated and intracellular cAMP levels are raised when the receptor is stimulated. The GCGR gene in humans is responsible for encoding the glucagon receptor. The liver and kidneys are the primary sites of glucagon receptor expression, with smaller amounts of these receptors also present in the heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V20593 | L-168,049 | 191034-25-0 | L-168,049 (L 168,049; L168,049) is a novel, selective, orally bioactive and non-peptidyl antagonist of human glucagon receptor (GR) with anti-diabetic activity. |
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V2961 | LGD-6972 | 1207989-09-0 | LGD-6972 (LGD6972; MB-11262) is a novel and orally bioavailable glucagon receptor antagonist with the potential to be used for treating type 2 diabetes (T2DM). |
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V4643 | Liraglutide | 204656-20-2 | Liraglutide, a Glucagon-like Peptide 1 (GLP-1) analog, is a potent agonist of the Glucagon-like Peptide 1 receptor. |
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V2751 | Lixisenatide | 320367-13-3 | Lixisenatide (ZP10A; ZP-10A; AVE-0010; AVE0010; Lyxumia, Adlyxin) is a short-acting agonist of the glucagon-like peptide-1 receptor (GLP-1R) with anti-diabetic effects. |
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V31946 | Lixisenatide acetate | 1997361-87-1 | Lixisenatide acetate (AVE-0010; ZP-10A; Adlyxin; Lyxumia; ZP10A), the acetate salt ofLixisenatide, is a potent and short-acting agonist of the glucagon-like peptide-1 receptor (GLP-1R) approved in 2016 for the treatment of type 2 diabetes mellitus (T2DM). |
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V74562 | Lotiglipron (PF-07081532) | 2401892-75-7 | Lotiglipron (PF-07081532) is an orally bioactive GLP-1R agonist. |
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V74572 | LSN3318839 | 2764704-18-7 | LSN3318839 is an orally bioavailable allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R). |
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V74561 | Mazdutide (IBI-362; LY-3305677; OXM-3) | 2259884-03-0 | Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. |
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V80706 | Mazdutide TFA (IBI-362 TFA; LY-3305677 TFA; OXM-3 TFA) | Mazdutide (IBI-362; LY-3305677) TFA is a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR) and a long-acting synthetic gastric acid modulator analogues. | |
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V80939 | Neuropeptide Y, porcine TFA | Neuropeptide Y, porcine TFA is a bioactive peptide present in pig brain that can inhibit secretin-stimulated pancreatic secretion. | |
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V80957 | NN1177 (NNC9204-1177) | NN1177 is a long-acting GLP-1/glucagon receptor co-agonist. | |
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V22035 | NNC0640 | 307986-98-7 | NNC-0640 is a potent negative allosteric modulator (NAM) of the human glucagon receptor (GCGR) with IC50 of 69.2 nM. |
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V74564 | Oxyntomodulin (bovine, porcine) (Glucagon-37 (bovine, porcine)) | 62340-29-8 | Oxyntomodulin (bovine, porcine) is a 37-amino-acid peptide hormone that is a glucagon-like peptide 1 (GLP-1) receptor agonist (activator). |
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V81023 | Oxyntomodulin (bovine, porcine) (TFA) (Glucagon-37 (bovine, porcine) (TFA)) | Oxyntomodulin (bovine, porcine) TFA is a 37-amino-acid peptide hormone that is a glucagon-like peptide 1 (GLP-1) receptor agonist. | |
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V74597 | Pegsebrenatide (NLY01) | 2243292-26-2 | Pegsebrenatide (NLY01) is a long-acting GLP-1R agonist. |
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V81075 | Pemvidutide TFA | Pemvidutide (TFA) is a dual GLP-1R/GCGR agonist that causes significant reductions in body weight, liver fat, and serum lipids. | |
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V4483 | PF-06291874 | 1393124-08-7 | PF-06291874 is a novel, highly potent glucagon receptor antagonist with favorable pharmacokinetics such as low in vivo clearance and excellent oral bioavailability in both rats and dogs. |
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V74563 | Retatrutide (LY3437943) | 2381089-83-2 | Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic peptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). |
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V81284 | Retatrutide acetate (LY3437943 acetate) | Retatrutide (LY3437943) acetate is a triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic peptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). | |
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V76561 | Retatrutide TFA (LY3437943 TFA) | Retatrutide (LY3437943) TFA is a triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic peptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). |
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