The acetylcholine receptors known as mAChRs (muscarinic acetylcholine receptors) are found in the cell membranes of some neurons and other cells. The primary end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system is one of their many functions. Because they are more sensitive to muscarine than to nicotine, mAChRs are so named. Nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also significant in the autonomic nervous system, are their counterparts. Numerous medications and other substances, such as scopolamine and pilocarpine, act as selective agonists or antagonists on these two different receptors. The brain and the autonomic ganglia are both rich sources of the neurotransmitter acetylcholine (ACh).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4096 | BQCA | 338747-41-4 | BQCA, a benzylquinolone carboxylic acid, is a potent, highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR). |
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V79460 | Clidinium-d5 bromide (Ro 2-3773-d5) | Clidinium-d5 (bromide) is deuterium-labeled Clidinium bromide. | |
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V38749 | Clozapine N-oxide diHCl | 2250025-93-3 | Clozapine N-oxide diHCl is a major metabolite of Clozapine which is an antipsychotic acting as an antagonist of dopamine and other receptors such as muscarinic M1 receptor. |
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V70555 | Cyclopentolate (DL-Cyclopentolate) | 512-15-2 | Cyclopentolate (DL-Cyclopentolate) is an atropine-like muscarinic receptor antagonist (inhibitor) with a pKB value of 7.8 for ciliary muscle muscarinic receptors. |
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V70532 | Darifenacin-d4 (UK-88525-d4) | 1095598-84-7 | Darifenacin-d4 is the deuterium labelled form of Darifenacin. |
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V70544 | DAU 5884 hydrochloride | 131780-48-8 | DAU 5884 HCl is a potent muscarinic M3 receptor antagonist. |
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V79994 | Deschloroclozapine dihydrochloride | Deschloroclozapine di-HCl is a metabolite of clozapine and a potent muscarinic DREADDs agonist. | |
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V79107 | DIBA-Cy5 | DIBA-Cy5 is a DIBA fluorescence antagonist consisting of DIBA-alkyne-conjugated Cyanine5 fluorophore (Cy5) and polyethylene glycol (PEG) biomolecules. | |
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V79117 | Dicyclomine-d4 (Dicycloverine-d4) | Dicyclomine-d4 is the deuterium labelled form of Dicyclomine. | |
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V20245 | DREADD agonist 21 | 56296-18-5 | DREADD agonist 21 is a potent agonist (EC50=1.7 nM) of the human muscarinic acetylcholine M3 receptor (hM3Dq). |
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V70504 | DREADD agonist 21 dihydrochloride | 2250025-92-2 | DREADD agonist 21 diHCl is a potent agonist (EC50=1.7 nM) of the human muscarinic acetylcholine M3 receptor (hM3Dq). |
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V70500 | Emraclidine (CVL-231) | 2170722-84-4 | Emraclidine (CVL-231) is a muscarinic M4 receptor-PAM (positive allosteric modulator) (WO2018002760, compound 11). |
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V70517 | Eucatropine | 100-91-4 | Eucatropine is a potent muscarinic acetylcholine receptor (mAChR) inhibitor (antagonist) with IC50 of 0.583 μM. |
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V70545 | Fesoterodine-d7 fumarate (fesoterodine fumarate-d7; fesoterodine fumarate-d7) | 2747918-94-9 | Fesoterodine-d7 (fumarate) is the deuterated form of Fesoterodine fumarate. |
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V70536 | Flavoxate-d4 hydrochloride (flavoxate-d4 hydrochloride) | 1189678-43-0 | Flavoxate-d4 ( HCl) is the deuterated form of Flavoxate HCl. |
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V70525 | G-Protein antagonist peptide | 143675-79-0 | G-Protein antagonist peptide is a substance P-related peptide that can inhibit/disrupts the binding of G protein to its receptor. |
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V76963 | G-Protein antagonist peptide TFA | G-Protein antagonist peptide TFA is a truncated substance P-related peptide that competes with receptors for G protein binding. | |
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V70554 | Guvacoline hydrobromide | 17210-51-4 | Guvacoline HBr is a pyridine alkaloid found in Areca triandra and works as a full agonist at atrial and ileal muscarinic receptors (mAChR). |
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V12158 | Harmaline | 304-21-2 | Harmaline is a naturally occuring, beta-carboline/fluorescent indole alkaloid extracted from seeds of PEGANUM. |
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V70531 | Homatropine | 87-00-3 | Homatropine is an orally bioactive muscarinic acetylcholine receptor blocker (antagonist) that works as an anticholinergic agent. |
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