The acetylcholine receptors known as mAChRs (muscarinic acetylcholine receptors) are found in the cell membranes of some neurons and other cells. The primary end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system is one of their many functions. Because they are more sensitive to muscarine than to nicotine, mAChRs are so named. Nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also significant in the autonomic nervous system, are their counterparts. Numerous medications and other substances, such as scopolamine and pilocarpine, act as selective agonists or antagonists on these two different receptors. The brain and the autonomic ganglia are both rich sources of the neurotransmitter acetylcholine (ACh).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70543 | Homatropine hydrochloride | 637-21-8 | Homatropine HCl is an orally bioactive anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. |
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V4682 | Imidafenacin | 170105-16-5 | Imidafenacin (formerly also known as KRP-197 and ONO-8025) is a novel, potent and selective inhibitor of M3 receptors with Kb of 0.317 nM and with less potency for M2 receptors (IC50 = 4.13 nM). |
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V76885 | Ipratropium-d3 bromide (Sch 1000-d3) | Ipratropium-d3 (bromide) is the deuterated form of Ipratropium bromide. | |
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V76884 | Ipratropium-d7 bromide (Sch 1000-d7 (bromide)) | Ipratropium-d7 (bromide)e is the deuterated form of Ipratropium bromide. | |
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V70527 | J-104129 | 244277-89-2 | J-104129 is a selective and orally bioactive muscarinic M3 receptor blocker (antagonist) (Ki = 4.2 nM). |
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V70510 | JHU37152 | 2369979-67-7 | JHU37152 is a potent and BBB (blood-brain barrier) permeable (penetrable) DREADD agonist/activator with EC50s of 5 nM and 0.5 nM for hM3Dq and hM4Di DREADDs, respectively. |
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V76823 | L-Hyoscyamine-d3 (Daturine-d3) | L-Hyoscyamine-d3 is the deuterium labelled form of L-Hyoscyamine. | |
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V70541 | M1/M2/M4 muscarinic agonist 1 | 2640109-42-6 | M1/M2/M4 muscarinic agonist 1 (compound 42) is a muscarinic M4/M1/M2 agonist/activator with EC50s of 6.5, 26 and 210 nM for M4/M1/M2, respectively. |
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V79209 | M1/M2/M4 muscarinic agonist 2 | M1/M2/M4 muscarinic agonist 2 (compound 43) is a muscarinic mAChR M1/M2/M4 agonist/activator with EC50s of 30 nM, 200 nM and 6.2 nM respectively. | |
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V70526 | M1/M2/M4 muscarinic agonist 3 | 2640109-28-8 | M1/M2/M4 muscarinic agonist 3 (compound 45) is a muscarinic mAChR M1/M2/M4 agonist/activator with EC50s of 3.2 nM, 32 nM and 1.7 nM respectively. |
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V79200 | M1/M4 muscarinic agonist 1 | M1/M4 muscarinic agonist 1 (Compound 41) is a selective muscarinic M4/M1 agonist/activator with EC50s of 14 and 55 nM for M4 and M1, respectively. | |
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V70534 | M1/M4 muscarinic agonist 3 | 2640109-30-2 | M1/M4 muscarinic agonist 3 (compound 44) is a muscarinic mAChR M1/M4 agonist/activator with EC50s of 31 nM and 9.3 nM, respectively. |
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V80656 | M3/PDE4 modulator-1 | M3/PDE4 modulator-1 (compound 10f) is a bifunctional molecule that is an M3 mAChR antagonist and a PDE4 inhibitor. | |
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V70542 | mAChR antagonist 1 | 101491-79-6 | mAChRagonist 1 (compound 4a) is a mAChR antagonist (inhibitor) with Kis of 255 nM, 121 nM, 158 nM and 255 nM for M1, M3, M4 and M5 isoforms, respectively. |
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V33631 | mAChR-IN-1 | 119391-56-9 | mAChR-IN-1 is a potent inhibitor of the muscarinic cholinergic receptor mAChR with IC50 of 17 nM. |
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V25272 | Mepenzolate Bromide | 76-90-4 | Mepenzolate Bromide is a muscarinic antagonist (Kis = 0.68 and 2.6 nM for human M2 and M3 receptors, respectively) used to treat gastrointestinal disorders. |
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V70508 | Methoctramine tetrahydrochloride | 104807-46-7 | Methoctramine tetraHCl is a potent cardioselective M2 muscarinic receptor blocker (antagonist). |
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V70539 | Milameline (CI-979; RU35926) | 139886-32-1 | Milameline is a muscarinic receptor agonist (activator) that improves cognition. |
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V70506 | MK-6884 | 2102194-04-5 | MK-6884 is an M4 muscarinic receptor PAM (positive allosteric modulator) with a Ki of 0.19 nM. |
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V4325 | MK-7622 | 1227923-29-6 | MK-7622 is a novel, potent and highly selective positive allosteric modulator of the M1 muscarinic receptor that has entered Phase II studies in patients with Alzheimer's disease. |
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