|
V70613
|
MMPIP hydrochloride
|
1215566-78-1 |
MMPIP HCl is an allosteric and selective metabotropic glutamate receptor 7 (mGluR7) antagonist (KB range 24-30 nM). |
|
V3421
|
MPEP hydrochloride
|
219911-35-0 |
MPEP hydrochloride is a highly potent, selective, and non-competitive antagonist of mGlu5 receptor with IC50 of 36 nM, it exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors. |
|
V70611
|
MTEP
|
329205-68-7 |
MTEP is a potent, noncompetitive and selective mGluR5 antagonist. |
|
V70621
|
NPEC-caged-LY379268
|
1315379-62-4 |
NPEC-caged-LY379268 is a Group II mGluR agonist. |
|
V12032
|
PHCCC
|
179068-02-1 |
PHCCC is a potent PAM (positive allosteric modulator) of mGluR4 and a Group I metabotropic glutamate receptor antagonist with IC50 of ~ 3 μM. |
|
V3342
|
Ro 67-7476
|
298690-60-5 |
Ro 67-7476 is a novel and selective positive allosteric modulator of mGlu1 receptors. |
|
V70616
|
trans-ACPD (Trans-(±)-ACP)
|
67684-64-4 |
trans-ACPD is a metabotropic receptor agonist (activator) that promotes calcium ion activity and generates inward current. |
|
V70596
|
UPF-523 (AIDA)
|
168560-79-0 |
UPF-523 (AIDA) is a rigid (carboxyphenyl) glycine analogue and a potent and specific antagonist of group I metabotropic glutamate receptor (mGlu1a) with IC50 of 214 μM. |
|
V27895
|
UV-0155041
|
1093757-42-6 |
UV0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). |
|
V28110
|
VU-1545
|
890764-63-3 |
VU-1545 (VU1545) is a novel and potent modulator of metabotropic glutamate receptor 5, or positive allosteric modulator (mGluR5 PAM) (Ki =156 nM and EC50 = 9.6 nM). |
|
V70598
|
VU-29
|
890764-36-0 |
VU-29 is a PAM (positive allosteric modulator) of the metabotropic glutamate 5 (mGlu5) receptor (EC50=9 nM, Ki=244 nM for rmGluR5). |
|
V70638
|
VU0029251
|
330819-85-7 |
VU0029251 is a mGluR5 partial antagonist (Ki: 1.07 μM). |
|
V70609
|
VU0155041 sodium
|
1259372-69-4 |
VU0155041 sodium is a specific mGluR4 mixed allosteric agonist/PAM (positive allosteric modulator) with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. |
|
V70610
|
VU0360172 hydrochloride
|
1309976-62-2 |
VU0360172 HCl is a potent and specific PAM (positive allosteric modulator) of the mGlu5 receptor with EC50 of 16 nM and a Ki of 195 nM. |
|
V70607
|
VU0364770 hydrochloride
|
1414842-70-8 |
VU0364770 HCl is a potent and specific mGlu4 PAM (positive allosteric modulator). |
|
V32195
|
VU0650786
|
1809085-30-0 |
VU0650786 is a novel, potent, selective and CNS permeable negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. |
|
V70627
|
VU6004909
|
1860797-76-7 |
VU6004909 is a PAM (positive allosteric modulator) of mGlu5 receptor (pEC50= 7.59). |
|
V31649
|
VU6005649
|
2137047-43-7 |
VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively. |
|
V70606
|
VU6010572
|
2126784-39-0 |
VU6010572 is a potent and specific mGlu3 NAM (negative allosteric modulator) with IC50 of 245 nM. |
|
V3321
|
VU6012962
|
2313526-86-0 |
VU6012962 is a novel, potent, orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) with an IC50 of 347 nM. |