Integral membrane proteins called serotonin transporters (SERTs) move serotonin from synaptic spaces into presynaptic neurons. Serotonin's function is effectively terminated and neuronal transmission is stopped by SERTs, which reabsorb it in the synaptic cleft. Reuptake of serotonin is essential for avoiding nerve overstimulation.
By delivering 5-hydroxytryptamine (5HT) to neurons and glial cells, the serotonin transporter (SERT) controls the extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain. Drugs used to treat emotional disorders, such as depression, primarily target the human SERT (hSERT). The bacterial leucine transporter (LeuT), for which a high resolution crystal structure is now available, is a member of the solute carrier 6 family, which also includes hSERT.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70021 | Desvenlafaxine-d6 (O-desvenlafaxine d6) | 1062605-69-9 | Desvenlafaxine-d6 is the deuterium labelled form of Desvenlafaxine. |
|
V70023 | Dextromilnacipran ((1R,2S)-milnacipran; F2696) | 96847-55-1 | Dextromilnacipran (F2696; (1R,2S)-milnacipran), the enantiomer of milnacipran, is a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. |
|
V70017 | Edivoxetine hydrochloride (LY 2216684 hydrochloride) | 1194374-05-4 | Edivoxetine (HCl) is a potent and selective norepinephrine reuptake inhibitor (NERI) used in depression or attention-deficit/hyperactivity disorder. |
|
V70012 | Escitalopram-d6 oxalate (escitalopram d6 oxalate) | 1217733-09-9 | Escitalopram-d6 (oxalate) is the deuterated form of Escitalopram oxalate. |
|
V94253 | Fluoxetine oxalate | 114414-02-7 | Fluoxetine oxalate is a selective serotonin reuptake inhibitor (SSRI). |
|
V79931 | Fluvoxamine-d4 maleate (DU-23000-d4 (maleate)) | Fluvoxamine-d4 (maleate) is the deuterium labelled form of Fluvoxamine maleate. | |
|
V87831 | Histamine H3 antagonist-1 | 1000392-25-5 | Histamine H3 antagonist-1 (Compound 10o) is a histamine H3 antagonist and serotonin reuptake inhibitor that can be used in depression research. |
|
V87834 | Lubazodone | 161178-07-0 | Lubazodone is a selective serotonin reuptake inhibitor that is used in the study of depression. |
|
V97252 | MAO-A/SERT-IN-1 | 3001361-38-9 | MAO-A/SERT-IN-1 is a MAO-A/serotonin transporter (SERT) inhibitor. |
|
V107540 | N-Nitroso fluoxetine | 150494-06-7 | N-nitrosofluoxetine is a derivative of fluoxetine. |
|
V70009 | Nardoguaianone J (10-epi-Nardoguaianone K) | 443128-64-1 | Nardoguaianone J, a guaiac compound, is extracted from the roots of Nardostachys chinensis. |
|
V70028 | Nardosinonediol (Tetrahydronardosinon) | 20489-11-6 | Nardosinonediol (Tetrahydronardosinon) is a serotonin transporter (SERT) inhibitor. |
|
V87840 | Nitroxazepine hydrochloride | 16398-39-3 | Nitroxazepine hydrochloride is a tricyclic antidepressant (TCA) used to treat depression. |
|
V103111 | Norfluoxetine oxalate | 107674-50-0 | Norfluoxetine oxalate is a metabolite of fluoxetine. |
|
V84069 | rel-HDMP 28 hydrochloride | 219915-69-2 | |
|
V70007 | rel-Sertraline-d3 hydrochloride (sertraline d3 hydrochloride (hydrochloride)) | 1330180-66-9 | rel-Sertraline-d3 ( HCl) is the deuterated form of Sertraline HCl. |
|
V70002 | SERT-IN-2 | 2055228-33-4 | SERT-IN-2 is a potent SERT inhibitor (IC50=0.58 nM) with antidepressant activity. |
|
V87833 | SERT-IN-3 | 289717-03-9 | SERT-IN-3 (compound 12) is an inhibitor of serotonin transporter (SerT). |
|
V87830 | SNRI-IN-1 | 887766-95-2 | SNRI-IN-1 (Compound 7a) is a dual monoamine reuptake inhibitor of serotonin and norepinephrine with a P-glycoprotein efflux effect ratio of 20. |
|
V103122 | Tampramine | 83166-17-0 | Tanpamin (47) is a phenothiazine drug that can reverse multidrug resistance with ED50 values of 60 μM (P388 cells) and 60 μM (P388/ADR cells). |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
