Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73585 | Tetraethylammonium chloride | 56-34-8 | Tetraethylammonium chloride is a non-selective potassium channel blocker. |
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V73651 | Tipepidine | 5169-78-8 | Tipepidine reversibly inhibits dopamine D2 receptor-mediated GIRK currents (IDA(GIRK)), thereby activating VTA dopamine neurons, with IC50 of 7.0 μM for IDA(GIRK). |
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V73635 | tKIM | 326921-25-9 | TKIM is a TREK-1 channel inhibitor (antagonist) with IC50 of 2.96 μM. |
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V0192 | Tolbutamide (HLS-831) | 64-77-7 | Tolbutamide (also known as HLS 831; trade names: Artosin, Diabetol, Orinase),a sulfonylurea analog,is a potent and selectiveinhibitor of potassium channel used as an oral blood-glucose-lowering/hypoglycemicmedication. |
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V1674 | TRAM-34 | 289905-88-0 | TRAM-34 (TRAM34;TRAM 34 Triarylmethane-34)is an inhibitor of Ca2+-activated K+ channel (IKCa1, KCa3.1) with important biological activity. |
|
V73633 | Tripamide | 73803-48-2 | Tripamide is an orally bioactive sulfonamide diuretic anti-hypertensive (blood pressure lowering) agent. |
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V73634 | TWIK-1/TREK-1-IN-1 | 1440532-30-8 | TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor (blocker/antagonist) of the TWIK-related potassium channel (Potassium Channel) TREK-1. |
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V73621 | TWIK-1/TREK-1-IN-2 | 1440532-32-0 | TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. |
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V73617 | TWIK-1/TREK-1-IN-3 | 1440532-33-1 | TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor (blocker/antagonist) of TWIK-related potassium channel (Potassium Channel) TREK-1. |
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V1684 | Verdinexor (KPT-335) | 1392136-43-4 | This product has been discontinued. |
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V29291 | Vernakalant (RSD-1235) | 794466-70-9 | Vernakalant(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. |
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V73628 | Vm24-toxin (Vaejovis mexicanus peptide 24) | 1373890-79-9 | Vm24-toxin is a toxin peptide extracted from the Mexican scorpion Vaejovis mexicanus smithy. |
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V1677 | Vonoprazan Fumarate (TAK-438) | 1260141-27-2 | Vonoprazan Fumarate (formerly TAK-438, TAK 438, trade name Takecab), the fumarate salt ofVonoprazan, is a novel,orally bioactive and potent P-CAB (potassium-competitive acid blocker) that has been approved in Janpan in 2015for the treatment of gastroduodenal ulcer and reflux esophagitis. |
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V28072 | VU0134992 | 755002-90-5 | VU0134992 is the first isoform-preferred, orally bioactive and selective inwardly rectifying potassium channel Kir4.1 blocker with IC50 of 0.97 μM. |
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V76349 | VU0463271 quarterhydrate | VU0463271 quarterhydrate is a potent inhibitor of the neurospecific potassium chloride cotransporter 2 (KCC2) with IC50 of 61 nM. | |
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V3377 | VU0529331 | 1286725-49-2 | VU0529331 is a novel, potent and modestly selective activator of non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) withEC50s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively. |
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V79852 | VU6036720 | VU6036720 is a potent and specific in vitro inhibitor of Kir4.1/5.1. | |
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V76348 | VU6036720 hydrochloride | VU6036720 HCl is a potent and specific in vitro inhibitor of Kir4.1/5.1. | |
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V73637 | XE991 | 122955-42-4 | XE 991 di-HCl is a Kv7 (KCNQ) channel blocker that can effectively inhibit Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels and M-current. |
|
V21023 | XE991 HCl (LS190926) | 122955-13-9 | XE991 diHCl (LS190926) is a novel, potent and selective blocker of KCNQ (Kv7) voltage-gated potassium channels. |
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