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Casein Kinase

Casein Kinase

The ubiquitous Ser/Thr kinases known as casein kinases (CKs) control a variety of cellular processes in eukaryotes, including the phosphorylation of proteins that are targets for degradation by the ubiquitin-proteasome system (UPS). Casein kinase-1 (CK-1) and casein kinase-2 (CK-2) have both been extensively characterized.
Mammals have at least seven different isoforms of CK1 kinases (,, 1-3,, and ), and these enzymes phosphorylate different substrates to participate in a variety of physiological processes including DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis.A highly pleiotropic serine-threonine kinase called casein kinase 2 (CK2) phosphorylated more than 300 proteins, many of which are involved in the regulation of cellular processes like signal transduction, transcriptional control, apoptosis, and the cell cycle.

Casein Kinase related products

Structure Cat No. Product Name CAS No. Product Description
(E/Z)-GO289 V52838 (E/Z)-GO289 694522-87-7 (E/Z)-GO289 is a potent and specific inhibitor of casein kinase 2 (CK2) (IC50=7 nM).
1,2,5,8-四羟基蒽酮 V9819 Quinalizarin 81-61-8 Quinalizarin is a potent, ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor (IC50= 110nM),superior to the first-in-class CK2 inhibitor, CX-4945.
Ac-ESMD-CHO V55064 Ac-ESMD-CHO 191338-87-1 Ac-ESMD-CHO is an inhibitor (blocker/antagonist) of caspase-3 and caspase-7.
Ac-VDVAD-CHO V55062 Ac-VDVAD-CHO 194022-51-0 Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50= 46 and 15 nM).
AMG-548 dihydrochloride V52425 AMG-548 dihydrochloride 2518299-32-4 AMG-548 di-HCl is an orally bioactive, selective p38α inhibitor (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM) and >1000-fold selective for p38γ and p38δ.
AMG-548 hydrochloride V52424 AMG-548 hydrochloride 2437438-16-7 AMG-548 HCl is an orally bioactive, selective p38α inhibitor (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM) and >1000-fold selective for p38γ and p38δ.
Antiproliferative agent-46 V85448 Antiproliferative agent-46
BMS-986397 V99683 BMS-986397 2564486-44-6 BMS-986397 is a cereblon-based CK1α (casein kinase 1α) molecular glue degrader that causes rapid apoptosis and cell cycle arrest in TP53 wild-type AML (acute myeloid leukemia) cells.
BTX161 V52313 BTX161 2052301-24-1 BTX161, a Thalidomide analogue, is a potent CKIα degrader.
Casein kinase 1δ-IN-1 V69794 Casein kinase 1δ-IN-1 851871-94-8 Casein kinase 1δ-IN-1 (compound 822) is an inhibitor (blocker/antagonist) of casein kinase 1δ (CK1δ) with an inhibitory effect of greater than 5%.
Casein kinase 1δ-IN-10 V69793 Casein kinase 1δ-IN-10 332074-85-8 Casein kinase 1δ-IN-10 is a casein kinase 1δ (CK1δ) inhibitor (WO2012080729A2; compound 685).
Casein kinase 1δ-IN-14 V69789 Casein kinase 1δ-IN-14 793722-88-0 Casein kinase 1δ-IN-14 (compound 481) is a casein kinase inhibitor that may be utilized to study neurodegenerative diseases such as AD/Alzheimer's disease.
Casein kinase 1δ-IN-15 V88599 Casein kinase 1δ-IN-15 2765264-27-3 Casein kinase 1δ-IN-15 is an inhibitor of casein kinase 1 (CK1δ) with IC50 of 0.045 μM.
Casein kinase 1δ-IN-3 V69792 Casein kinase 1δ-IN-3 349438-77-3 Casein kinase 1δ-IN-3 (Compound 23a) is a casein kinase 1δ (CK1d) inhibitor (antagonist) with pIC50 of 6.5376 M.
Casein kinase 1δ-IN-4 V69791 Casein kinase 1δ-IN-4 851168-98-4 Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ.
Casein kinase 1δ-IN-5 V69795 Casein kinase 1δ-IN-5 1579991-10-8 Casein kinase 1δ-IN-5 is a potent and specific inhibitor of protein kinase CK-1δ with IC50 of 47 nM.
Casein kinase 1δ-IN-6 V69785 Casein kinase 1δ-IN-6 1579991-01-7 Casein kinase 1δ-IN-6 is a potent and specific inhibitor of protein kinase CK-1δ with IC50 of 23 nM.
Casein kinase 1δ-IN-7 V69790 Casein kinase 1δ-IN-7 764694-25-9 Casein kinase 1δ-IN-7 (compound 497) is a Casein kinase 1δ inhibitor that may be utilized in the study of neurodegenerative diseases such as AD/Alzheimer's disease.
Casein kinase 1δ-IN-8 V69787 Casein kinase 1δ-IN-8 851396-73-1 Casein kinase 1δ-IN-8 (compound 494) is an inhibitor (blocker/antagonist) of casein kinase 1δ, which may be utilized to treat neurodegenerative diseases such as AD/Alzheimer's disease.
Casein kinase 1δ-IN-9 V69797 Casein kinase 1δ-IN-9 854355-54-7 Casein kinase 1δ-IN-9 (compound 737) is a potent inhibitor of casein kinase 1δ (CK1δ/CK15).
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