ROCK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

+MORE

ROCK

The AGC (PKA/PKG/PKC) family of serine-threonine kinases includes ROCK (Rho-associated protein kinase). Animals such as chicken, zebrafish, Xenopus, and mammals also have ROCKs (ROCK1 and ROCK2). With a molecular weight of 158 kDa, human ROCK1 is a significant RhoA small GTPase downstream effector. A kinase domain, an acoiled-coil region, and a Pleckstrin homology (PH) domain make up a mammalian ROCK. If RhoA-GTP is absent, the kinase activity of ROCKs is reduced by an autoinhibitory intramolecular fold. Since ROCK is a downstream effector protein of the small GTPase Rho, one of the primary regulators of the cytoskeleton, ROCK is involved in a variety of different cellular phenomena.

ROCK related products

Cat No.	Product Name	CAS No.	Product Description
V35094	CaMKP inhibitor sodium	52789-62-5	CaMKP inhibitor sodium is a selective ROCK1 inhibitor (antagonist) with IC50 of 14 nM.
V52297	CAY10746	2247240-76-0	CAY10746 is a selective Rho kinase (ROCK) inhibitor.
V53061	Cotosudil	1258833-31-6	Cotosudil is a ROCK kinase inhibitor used in glaucoma or ocular hypertension research.
V55052	Glycyl H-1152 hydrochloride	913844-45-8	Glycyl H-1152 HCl is a glycosyl analogue of the Rho-kinase inhibitor H-1152 di-HCl.
V2730	GSK180736A	817194-38-0	GSK180736A (GSK-180736A) is a GRK2 inhibitor thatwasdeveloped as a novel and potent Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitor whichbinds to GRK2 (G protein-coupled receptor kinase 2) with IC50of 0.77 μM; G protein-coupled receptors (GPCRs) are central to many physiological processes.
V2561	GSK269962 (GSK269962A)	850664-21-0	GSK269962 (also known as GSK269962A) is a novel, potent and selective inhibitor of ROCK (Rho-associated protein kinase) with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
V3320	GSK269962 HCl	2095432-71-4	GSK269962 HCl (also called GSK-269962A HCl),the hydrochloride salt ofGSK 269962A, is a selective ROCK (Rho-associated protein kinase) inhibitor with potential antihypertensive and cardioprotective activity.
V1345	GSK429286A	864082-47-3	GSK429286A (also known as RHO15;GSK 429286A;RHO-15;GSK-429286A)is a potent, orally bioactive, andselective inhibitor of ROCK1/2 with antihypertensive effects.
V67533	HA-100 dihydrochloride	210297-47-5	HA-100 di-HCl is a potent protein kinase inhibitor (antagonist) with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for PKG, PKA, PKC and MLC kinases respectively.
V52021	HA-100 hydrochloride	141543-63-7	HA-100 HCl is a potent protein kinase inhibitor (antagonist) with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for PKG, PKA, PKC and MLC kinases, respectively.
V51967	Hu7691	2360523-76-6	Hu7691 is an orally bioactive, selective Akt inhibitor (antagonist) with IC50s of 4.0 nM, 97.5 nM and 28 nM for Akt1, Akt2 and Akt3 respectively.
V51966	Hu7691 free base	2241232-43-7	Hu7691 free base is an orally bioactive, selective Akt inhibitor (antagonist) with IC50s of 4.0 nM, 97.5 nM and 28 nM for Akt1, Akt2 and Akt3 respectively.
V2563	Kobe0065	436133-68-5	Kobe0065 (Kobe 0065) is novel and potent inhibitor of the H-Ras-cRaf1 interaction whichexhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.
V2564	PD0166285	185039-89-8	PD0166285 (PD-0166285) is a novel and potent Wee1 and Chk1 inhibitor with anticancer activity and enzymatic activity at nanomolar concentrations (IC50s of 24 and 72 nM for WEE1 and Myt1, respectively).
V2562	RK-33	1070773-09-9	RK-33 is a potent and first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
V1346	RKI-1447	1342278-01-6	RKI-1447 (ROCK Inhibitor XIII; RKI 1447; RKI1447) is a potent small molecule inhibitor of ROCK1 and ROCK2 with potential antitumor activities againstbreast cancer.
V55726	ROCK-IN-5	692870-25-0	ROCK-IN-5 (compound IB-37) is a potent inhibitor of ROCK, ERK, GSK and AGC protein kinases.
V55727	ROCK-IN-6	2489328-74-5	ROCK-IN-6 is a potent ROCK2 inhibitor (antagonist) with IC50 of 2.19 nM.
V55725	ROCK-IN-7	2376635-95-7	ROCK-IN-7 (compound 9) is a ROCK kinase inhibitor.
V55724	ROCK-IN-8	1621103-79-4	ROCK-IN-8 (Example 4) is a ROCK inhibitor (antagonist) with IC50 of less than 100 nM.