The acquired immunodeficiency syndrome (AIDS), a condition in which the immune system gradually fails and life-threatening opportunistic infections and cancers proliferate, is brought on by the lentivirus (a subgroup of retrovirus) known as HIV. HIV infection happens when blood, semen, vaginal fluid, pre-ejaculate, or breast milk are shared. HIV can be found in these bodily fluids as both free virus particles and as a virus inside infected immune cells.Important immune system components like helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells are all infected by HIV. Apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells are some of the mechanisms by which HIV infection results in low levels of CD4+ T cells. Cell-mediated immunity is lost and the body becomes progressively more vulnerable to opportunistic infections when CD4+ T cell counts fall below a critical threshold.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V81736 | VIR-165 | VIR-165 is a modified form of a viral inhibitory peptide (VIRIP) that binds to a fusion peptide of the gp41 subunit and prevents its entry into target membranes. | |
|
V54243 | Wilfortrine (triptolide) | 37239-48-8 | Wilfortrine is a bioactive sesquiterpene alkaloid. |
|
V54267 | Zinlirvimab (10-1074) | 2417213-75-1 | Zinlirvimab is a humanized IgG1-λ2 HIV neutralizing antibody that targets the HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop). |
|
V76070 | β-Rubromycin | 27267-70-5 | β-Rubromycin is a potent and specific inhibitor of human immunodeficiency virus-1 (HIV-1) RNA-directed DNA polymerase (reverse transcriptase). |
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