Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V56424 | Apocynin-d3 (Acetovanillone-d3) | 80404-23-5 | Apocynin-d3 is the deuterium labelled form of Apocynin. |
|
V52404 | Apoptolidin | 194874-06-1 | Apoptolidin is a polyketide extracted from Nocardiopsis bacteria. |
|
V78674 | Apoptosis inducer 11 | Apoptosis inducer 11 (compound 3u) causes apoptosis through the mitochondrial pathway. | |
|
V34697 | Apoptosis inducer 12 | 1971096-01-1 | Apoptosis inducer 12 (Compound 3z) is an apoptosis inducer that causes apoptosis through the mitochondrial pathway and may be utilized in cancer research. |
|
V78102 | Apoptosis inducer 13 | Apoptosis inducer 13 (Compound Ru4) can induce cancer cell apoptosis (apoptosis) and inhibit cancer cell migration and invasion. | |
|
V85265 | Apoptosis inducer 14 | 2750370-67-1 | |
|
V54864 | APPA (4-acetoxy-1-acetyl-2-phenylpyrrole) | 100750-39-8 | APPA is an aldose reductase inhibitor. |
|
V85839 | AQIM-I | 2247881-73-6 | |
|
V78131 | ar-Turmerone-d3 ((+)-ar-Turmerone-d3) | ar-Turmerone-d3 is the deuterated form of ar-Turmerone. | |
|
V80267 | Ara-SH | Ara-SH is a mercaptopropionic acid-substituted analogue of Cytarabine. | |
|
V34679 | Arachidonoyl ethanolamide phosphate | 183323-26-4 | Arachidonoyl ethanolamide phosphate, an endocannabinoid, is an endogenous ligand for cannabinoid receptors in the central nervous system/CNS (CB1 subtype) and peripheral immune cells (CB2 subtype). |
|
V54808 | Ardisiacrispin B | 112766-96-8 | Ardisiacrispin B displays cytotoxicities in multifactorial drug-resistant cancer/tumor cells through iron toxicity and apoptotic cell death. |
|
V52399 | Argipressin acetate (Arg8-vasopressin acetate; AVP acetate) | 129979-57-3 | Argipressin (Arg8-vasopressin) (acetate) binds to vasoarginine vasopressin receptors V1, V2, and V3, with a Kd of 1.31 nM for V1 in A7r5 rat aortic smooth muscle cells. |
|
V52398 | ARN14494 | 1037837-27-6 | ARN14494 is a potent and specific serine palmitoyltransferase (SPT) inhibitor (antagonist) with IC50 of 27.3 nM. |
|
V56269 | Artemisinin-d3 (Qinghaosu-d3; NSC 369397-d3) | 176652-07-6 | Artemisinin-d3 is the deuterated form of Artemisinin. |
|
V52587 | Artesunate-d3 (artemisinate d3) | 1316303-44-2 | Artesunate-d3 is the deuterium labelled form of Artesunate. |
|
V52391 | AS-99 free base | 2323623-93-2 | AS-99 is a first-in-class, potent and specific ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemia activity. |
|
V52389 | ASK1-IN-2 | 2541792-70-3 | ASK1-IN-2 is a potent, orally bioactive inhibitor of apoptosis signal-regulated kinase 1 (ASK1) with IC50 of 32.8 nM. |
|
V54902 | ASK1-IN-4 | 1427538-26-8 | ASK1-IN-4 (Compound 17) is an ASK1 inhibitor (IC50=0.2 μM). |
|
V54874 | Asparanin A | 84633-33-0 | Asparanin A is an apoptosis inducer with anti-cancer activity. |
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