Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78475 | Antitumor agent-83 | Antitumor agent-83 is an activator of the pro-apoptotic protein BAX and has a significant antiproliferation effect on tumor cells. | |
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V34818 | Antitumor agent-92 | 2922842-01-9 | Antitumor agent-92 is an icariin analogue that can cause cell cycle arrest in the G0/G1 phase and cause apoptosis. |
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V78565 | Antitumor agent-96 | Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor. | |
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V34817 | Antitumor agent-97 | 2654024-16-3 | Antitumor agent-97 (compound 42) is an anticancer agent. |
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V78081 | Antitumor photosensitizer-4 | Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. | |
|
V52406 | AP-III-a4 hydrochloride (ENOblock hydrochloride) | 2070014-95-6 | AP-III-a4 (ENOblock) HCl is a non-substrate analog enolase inhibitor (antagonist) with IC50 of 0.576 uM. |
|
V52408 | APE1-IN-2 | 2923433-95-6 | APE1-IN-2 (compound AP1) is a Pt(IV) precursor that targets a key BER protein, apurinic/apyrimidine endonuclease 1 (APE1). |
|
V56424 | Apocynin-d3 (Acetovanillone-d3) | 80404-23-5 | Apocynin-d3 is the deuterium labelled form of Apocynin. |
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V52405 | Apolizumab (Hu1D10) | 267227-08-7 | Apolizumab (Hu1D10) is a humanized monoclonal antibody (mAb) directed against the human leukocyte antigen-DR beta chain. |
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V52404 | Apoptolidin | 194874-06-1 | Apoptolidin is a polyketide extracted from Nocardiopsis bacteria. |
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V78674 | Apoptosis inducer 11 | Apoptosis inducer 11 (compound 3u) causes apoptosis through the mitochondrial pathway. | |
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V34697 | Apoptosis inducer 12 | 1971096-01-1 | Apoptosis inducer 12 (Compound 3z) is an apoptosis inducer that causes apoptosis through the mitochondrial pathway and may be utilized in cancer research. |
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V78102 | Apoptosis inducer 13 | Apoptosis inducer 13 (Compound Ru4) can induce cancer cell apoptosis (apoptosis) and inhibit cancer cell migration and invasion. | |
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V85265 | Apoptosis inducer 14 | 2750370-67-1 | |
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V54864 | APPA (4-acetoxy-1-acetyl-2-phenylpyrrole) | 100750-39-8 | APPA is an aldose reductase inhibitor. |
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V85839 | AQIM-I | 2247881-73-6 | |
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V78131 | ar-Turmerone-d3 ((+)-ar-Turmerone-d3) | ar-Turmerone-d3 is the deuterated form of ar-Turmerone. | |
|
V80267 | Ara-SH | Ara-SH is a mercaptopropionic acid-substituted analogue of Cytarabine. | |
|
V34679 | Arachidonoyl ethanolamide phosphate | 183323-26-4 | Arachidonoyl ethanolamide phosphate, an endocannabinoid, is an endogenous ligand for cannabinoid receptors in the central nervous system/CNS (CB1 subtype) and peripheral immune cells (CB2 subtype). |
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V54808 | Ardisiacrispin B | 112766-96-8 | Ardisiacrispin B displays cytotoxicities in multifactorial drug-resistant cancer/tumor cells through iron toxicity and apoptotic cell death. |
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