Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V17715 | CCF-642 | 346640-08-2 | CCF-642 is a protein disulfide isomerase (PDI) inhibitor. |
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V2443 | CCI 007 | 939228-52-1 | CCI-007 is a cytotoxic small molecule with IC50 of 2.5-6.2 μM in MLL-rearranged sensitive infant leukemia cells. |
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V52291 | CCT128930 hydrochloride | 2453324-32-6 | CCT128930 HCl is a potent and specific AKT inhibitor (IC50=6 nM). |
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V53272 | CCT369260 | 2647503-57-7 | CCT369260 (compound 1) is an orally bioactive B-cell lymphoma 6 (BCL6) inhibitor (antagonist) with anti-tumor activity with IC50 of 520 nM. |
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V52269 | CDK8-IN-13 | 918523-75-8 | CDK8-IN-13 is a specific and orally bioactive CDK8 inhibitor (antagonist) with IC50 of 51.9 nM. |
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V52267 | CDK9-IN-7 | 2369981-71-3 | CDK9-IN-7 (compound 21e) is a selective, orally bioactive CDK9/cyclin T inhibitor (IC50=11 nM), which is more effective than inhibiting other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). |
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V52265 | Cearoin | 52811-37-7 | Cearoin enhances autophagy and causes apoptosis by promoting ROS production and activating ERK. |
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V54893 | Cedrelone | 1254-85-9 | Cedrelone is a limonoid and a phenazine biosynthesis-like domain protein (PBLD) activator. |
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V54916 | Celosin K | 1950579-53-9 | Celosin K can be extracted from seeds of Semen Celosiae. |
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V56412 | Ceramide C6-d7 | 2692624-22-7 | Ceramide C6-d7 is the deuterated form of Ceramide C6. |
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V52262 | Cetrelimab (JNJ 63723283; JNJ 3283) | 2050478-92-5 | Cetrelimab (JNJ 63723283; JNJ 3283) is a humanized IgG4κ monoclonal antibody (mAb) targeting PD-1. |
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V33465 | Chlamydocin | 53342-16-8 | Chlamydocin, a fungal metabolite, is a potent HDAC inhibitor (antagonist) with IC50 of 1.3 nM. |
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V78766 | ChoKα inhibitor-3 | ChoKα inhibitor-3 is a sulfur-containing choline kinase inhibitor. | |
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V77726 | ChoKα inhibitor-5 | ChoKα inhibitor-5 is a sulfur-containing choline kinase inhibitor. | |
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V52946 | Cholesteryl hemisuccinate (Cholesterol hydrogen succinate) | 1510-21-0 | Cholesteryl hemisuccinate is a substance with hepatoprotective and anti-cancer activity. |
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V85174 | Cholicamideβ (GMP) | ||
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V52254 | Chrysomycin A (Chr-A) | 82196-88-1 | Chrysomycin A (Chr-A) is an antibiotic derived from Streptomyces sp. |
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V52253 | Chrysosplenol D | 14965-20-9 | Chrysosplenol D, a methoxyflavonoid, induces ERK1/2-mediated apoptosis in triple-negative human breast cancer cells. |
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V52251 | Cimiside E (25-Anhydrocimigenol xyloside) | 154822-57-8 | Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside that has an apoptotic effect on gastric cancer cells with IC50 of 14.58 μM. |
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V54065 | Cinchonine hydrochloride (8R,9S)-Cinchonine hydrochloride; LA40221 hydrochloride | 5949-11-1 | Cinchonine HCl ((8R,9S)-Cinchonine HCl) is a natural compound found in the bark of the cinchona tree and has antimalarial activity. |
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