Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V56429 | Cysteamine-d4 hydrochloride (2-Aminoethanethiol-d4 hydrochloride; 2-Mercaptoethylamine-d4 hydrochloride) | 1219805-04-5 | Cysteamine-d4 ( HCl) is the deuterated form of Cysteamine HCl. |
|
V52790 | Cytarabine-d2 (cytarabine d2) | 40632-26-6 | Cytarabine-d2 is the deuterated form of Cytarabine. |
|
V52203 | Cytochalasin H | 53760-19-3 | Cytochalasin H is a naturally occurring compound extracted from the fungus Phomopsis sp. |
|
V35074 | Cytochrome C (cytochrome C) | 9007-43-6 | Cytochrome C is a multifunctional enzyme involved in cell life and death decisions. |
|
V54868 | Cytostatin | 682329-63-1 | Cytostatin is a potent and specific PP2A inhibitor (antagonist) with good anti-tumor activity. |
|
V53306 | CZL55 | 667408-87-9 | CZL55 is an inhibitor (blocker/antagonist) of caspase-1 with IC50 of 24 nM. |
|
V56399 | D-Mannitol-13C6 (Mannitol-13C6; Mannite-13C6) | 287112-34-9 | D-Mannitol-13C6 is 13C (carbon 13) labeled D-Mannitol. |
|
V35024 | d-Sophoridine ((+)-Sophoridine) | 83148-91-8 | d-Sophoridine ((+)-Sophoridine) is the dextrorotatory isomer of Sophoridine . |
|
V55006 | D-Trimannuronic acid | 66754-13-0 | D-Trimannuronic acid is an alginate oligomer found in seaweed, which can induce the secretion of TNF-α in mouse macrophages. |
|
V56425 | Dacarbazine-d6 (Imidazole Carboxamide-d6) | 1185241-28-4 | Dacarbazine-d6 is the deuterium labelled form of Dacarbazine. |
|
V52201 | Dalotuzumab (MK-0646; h7C10) | 1005389-60-5 | Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (mAb) (IgG1 type) targeting IGF-1R. |
|
V54805 | Damulin B (Damulin B) | 1202868-75-4 | Damulin B is a saponin compound found in Gynostemma pentaphylla. |
|
V17256 | Darinaparsin (ZIO101; SP02) | 69819-86-9 | Darinaparsin (ZIO-101, SP-02) is a novel and potent mitochondrial-targeted small molecule and an organic arsenic that is being developed for the treatment of various hematologic and solid cancers. |
|
V53296 | DB0614 | 2769753-47-9 | DB1113 (Example 24) is a bifunctional compound targeting protein kinase degradation. |
|
V53249 | DB1113 | 2769753-53-7 | DB1113 (Example 24) is a bifunctional compound targeting protein kinase degradation. |
|
V53084 | DB2115 tertahydrochloride | 1366126-19-3 | DB2115 (terta HCl) is a potent inhibitor of the bone marrow master regulator PU.1. |
|
V86304 | DDO-2728 | 3029515-97-4 | |
|
V54826 | De-O-Methyllasiodiplodin | 32885-82-8 | De-O-Mmethyllasiodiplodin is a cytotoxic compound that can be extracted from Ludwigia hyssopifolia. |
|
V56350 | Deferasirox-d4 (deferasirox d4) | 1133425-75-8 | Deferasirox-d4 is the deuterium labelled form of Deferasirox. |
|
V52585 | Deferiprone-d3 (deferiprone d3) | 1346601-82-8 | Deferiprone-d3 is the deuterium labelled form of Deferiprone. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
