Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54898 | Delphinidin 3-O-rutinoside chloride (Delphinidin 3-O-rutinoside chloride) | 15674-58-5 | Delphinidin 3-rutinoside chloride (Delphinidin 3-O-rutinoside chloride) is an active anthocyanin found in Solanum melongena extract. |
|
V54832 | Delta-12-Prostaglandin J2 (Δ12-PGJ2) | 87893-54-7 | Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with antiproliferation effects on the growth of a variety of tumor cells. |
|
V56249 | Demethoxycurcumin-d7 (Curcumin II-d7; Desmethoxycurcumin-d7; Monodemethoxycurcumin-d7) | 2470243-19-5 | Demethoxycurcumin-d7 is the deuterated form of Demethoxycurcumin. |
|
V54890 | Demethoxyfumitremorgin C | 111768-16-2 | Demethoxyfumitremorgin C is a secondary metabolite (SM, chemical compound) of the marine fungus Aspergillus fumigatus. |
|
V52188 | Demethylcantharidate disodium | 129-67-9 | Demethylcantharidate disodium is an endogenously produced metabolite that causes apoptosis in hepatoma cells through endoplasmic reticulum stress. |
|
V53091 | Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) | 2365172-82-1 | Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. |
|
V34793 | Dextran sulfate sodium salt (MW5000) | 9011-18-1 | Dextran sulfate sodium salt (MW5000) is an anhydroglucose polymer with a molecular weight of 5000. |
|
V85844 | DHP-B | ||
|
V35083 | Dibromoacetic acid | 631-64-1 | Dibromoacetic acid is a haloacetic acid that is often present in drinking water as a disinfection by-product and can cause many adverse reactions such as immunotoxicity and induction of apoptosis. |
|
V52572 | Diclofenac-d4 (Diclofenac d4) | 153466-65-0 | Diclofenac-d4 is the deuterium labelled form of Diclofenac. |
|
V52571 | Diclofenac-d4 sodium (Diclofenac sodium d4 (sodium salt)) | 154523-54-3 | Diclofenac-d4 (sodium) is the deuterium labelled form of Diclofenac sodium. |
|
V35044 | Didocosahexaenoin (docosahexaenoic acid diglyceride) | 124538-05-2 | Didocosahexaenoin is an omega-3 analogue that is a diglyceride of DHA and can be synthesized from DHA triglyceride. |
|
V54852 | Diffractaic acid | 436-32-8 | Diffractaic acid is the major component of U. longissimi and could be utilized as an effective pro-apoptotic agent in various disease studies. |
|
V77083 | Difopein TFA | Difopein (TFA) is a specific competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule) that blocks the ability of 14-3-3 to bind to target proteins and inhibits 14-3- 3/Interaction of ligands. | |
|
V56270 | Dihydroartemisinin-d3 (Dihydroqinghaosu-d3; β-Dihydroartemisinin-d3; Artenimol-d3) | 176774-98-4 | Dihydroartemisinin-d3 is the deuterium labelled form of Dihydroartemisinin. |
|
V3998 | DIM-C-PPHOH | 151358-47-3 | DIM-C-pPhOH (also known as C-DIM8) is a Nur77 (NR4A1) antagonist. |
|
V56430 | Dinoprost-d4 (Prostaglandin F2a-d4; PGF2α-d4) | 34210-11-2 | Dinoprost-d4 is the deuterium labelled form of Dinoprost. |
|
V52178 | Diosbulbin D | 66756-57-8 | Diosbulbin D is a potentially hepatotoxic compound extracted from Dioscorea bulbifera L. |
|
V83576 | Diselaginellin B | 1835299-12-1 | |
|
V52176 | Distamycin A (NSC-82150) | 636-47-5 | Distamycin A (NSC-82150), an oligopeptide antibiotic, is a minor groove binder that binds B-form DNA preferentially at A/T-rich sites. |
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