Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52144 | EB1 | 42951-68-8 | EB1 is an inhibitor (blocker/antagonist) of MNK kinase with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). |
|
V52143 | EC359 | 2012591-09-0 | EC359 is a specific, high-affinity and orally bioavailable leukemia inhibitory factor receptor (LIFR) inhibitor (antagonist) with a Kd of 10.2 nM that directly interacts with LIFR to effectively block LIF/ LIFR interactions. |
|
V85888 | ECDD-S16 | ||
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V54810 | Echitamine chloride (Ditaine chloride) | 6878-36-0 | Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris and has potent anticancer effect. |
|
V54813 | Eftozanermin alfa (ABBV-621) | 1820660-69-2 | Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. |
|
V52133 | EGFR-IN-11 | 2463200-44-2 | EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with IC50 of 18 nM against the triple mutation EGFRL858R/T790M/C797S. |
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V54905 | EGFR-IN-88 | 2944452-34-8 | EGFR-IN-88 (Compound 4i) is an EGFR inhibitor (IC50= 87 nM). |
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V54968 | ElteN378 | 1421366-99-5 | ElteN378 is an inhibitor (blocker/antagonist) of FKBP12e. |
|
V52129 | Enavatuzumab (enavatuzumab; PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)) | 1062149-33-0 | Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody (mAb) targeting the TNF-like weak inducer of apoptosis receptor (TWEAK). |
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V52126 | ENMD-1068 hydrochloride | 2703451-51-6 | ENMD-1068 HCl is a selective protease-activated receptor 2 (PAR2) antagonist. |
|
V52125 | Enpp/Carbonic anhydrase-IN-1 | 2883495-35-8 | Enpp/Carbonic anhydrase-IN-1 (compound 1e) is an effective inhibitor of Enpp and carbonic anhydrase, with IC50s of 1.36, 1.35, 3.00, 0.88, respectively for NPP1, NPP2, NPP3, CA-II, and CA-IX. |
|
V52124 | Enpp/Carbonic anhydrase-IN-2 | 2883495-39-2 | Enpp/Carbonic anhydrase-IN-2 (compound 1i) is an effective inhibitor of Enpp and carbonic anhydrase, with IC50s of 1.13, 1.07, 0.74, 0.33, respectively for NPP1, NPP2, NPP3, CA-IX, and CA-XII. |
|
V52122 | Enterodiol | 80226-00-2 | Enterodiol is converted by human gut bacteria from lignans found in a variety of whole grains, nuts, legumes, flaxseeds and vegetables. |
|
V35068 | Enterolactone | 78473-71-9 | Enterolactone is a bioactive phenolic metabolite known as mammalian lignan, derived from dietary lignans. |
|
V52648 | Enterolactone-d6 | 104411-11-2 | Enterolactone-d6 is the deuterated form of Enterolactone. |
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V54838 | EP12 | 2882916-73-4 | EP12 is a c-Myc inhibitor. |
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V53554 | EP3 | 749252-79-7 | EP3 is an antimicrobial peptide. |
|
V29309 | Epibrassinolide (24-Epibrassinolide; B1105; BP55) | 78821-43-9 | Epibrassinolide (24-Epibrassinolide; B1105; BP55) is a naturally occurring plant growth hormone which shows great potential to alleviate heavy metals and pesticide stress in plants. |
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V35077 | Epidermal growth factor (EGF) | 62253-63-8 | Epidermal growth factor (EGF) is a key regulator of cell survival. |
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V52116 | Epimedokoreanin B | 161068-53-7 | Epimedokoreanin B is a naturally occurring flavonoid with anti-cancer, anti-inflammatory and antibacterial effects. |
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