Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V54850 | FC-116 | 2417298-29-2 | FC-11 is a Tubulin inhibitor that can effectively inhibit tumor growth in mice. |
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V79394 | FD2157 | FD2157 is a photosensitive PI3K inhibitor (antagonist) with IC50s of 43 nM, 83 nM, 84 nM, 14 nM and PI3Kδ for PI3Kα, PI3Kβ and PI3Kγ respectively. | |
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V52096 | FD223 | 2050524-24-6 | FD223 is a potent and specific inhibitor of phosphoinositide 3-kinase delta (PI3Kδ). |
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V56440 | Fenbufen-d9 (fenbufen d9) | 1189940-96-2 | Fenbufen-d9 is the deuterium labelled form of Fenbufen. |
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V52999 | Fenobucarb (Zhongdingwei) | 3766-81-2 | Fenobucarb is a carbamate insecticide. |
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V56449 | Ferroptosis inducer-1 | 2375357-96-1 | Ferroptosis inducer-1 (compound BX-3a) is a ferroptosis inducer with anti-tumor potential. |
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V85802 | Ferroptosis-IN-6 | 1517780-59-4 | |
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V52094 | Ferruginol ((+)-Ferruginol) | 514-62-5 | Ferruginol ((+)-Ferruginol) is a natural diterpenoid that is an inhibitor (blocker/antagonist) of Epstein-Barr virus early antigen (EBV-EA) activation. |
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V11380 | FeTPPS | 90384-82-0 | FeTPPS is a 5,10,15,20-tetrakis (4-sulfophenyl) porphyrin ferric chloride peroxynitrite decomposition catalyst, which has obvious neuro-protection effects in experimental models of spinal cord injury. |
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V54821 | Fexapotide (NX-1207 free acid) | 492447-54-8 | Fexapotide (NX-1207 free acid) selectively causes apoptosis and reduces prostate volume at the cellular level. |
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V84425 | Fexapotide TFA (NX-1207 TFA) | ||
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V54802 | FG-3019 (Pamrevlumab; Anti-Human CTGF Recombinant Antibody) | 946415-13-0 | FG-3019 (Pamrevlumab) is a recombinant humanized antibody that binds connective tissue growth factor (CTGF). |
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V56331 | Fidaxomicin-d7 | 2143934-06-7 | Fidaxomicin-d7 is the deuterium labelled form of Fidaxomicin. |
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V79437 | FIZZ-1 (32-51) (mouse) | FIZZ-1 (32-51) (mouse) is a cysteine-rich secreted protein highly expressed by macrophages, bronchial epithelium, and type II alveolar epithelial cells (AEC) in allergic airway inflammation . | |
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V52092 | FK-3000 | 1054312-81-0 | FK-3000 is a potent antineoplastic/anticancer agent that suppresses the growth of cancer cells through apoptosis and induction of cell cycle arrest. |
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V54967 | FKBP51F67V-selective antagonist Ligand2 | 1680228-76-5 | FKBP51F67V-selective antagonist Ligand2 (example 3-3) is a potent FKBP51 F67V-selective antagonist ligand. |
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V85263 | FL77-24 (7-(4-Ethylphenyl)-FL118) | 2413582-39-3 | |
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V54915 | Flaccidoside II | 140694-19-5 | Flaccidoside II inhibits proliferation and causes apoptosis in malignant peripheral nerve sheath tumor (MPNST) cell lines. |
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V21069 | Flavokawain A | 64680-84-8 | Flavokawain A is a novel and potent NF-χB inhibitor |
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V52635 | Flubendazole-d3 (flubendazole d3) | 1173021-08-3 | Flubendazole-d3 is the deuterated form of Flubendazole. |
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