Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V28571 | Fludarabine triphosphate (F-ara-ATP) | 74832-57-8 | Fludarabine triphosphate (F-ara-ATP) is the bioactive metabolite of Fludarabine . |
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V56455 | Fluorescein-diisobutyrate-6-amide | 2375357-99-4 | Fluorescein-diisobutyrate-6-amide is a potent inducer of ferroptosis. |
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V52634 | Flurbiprofen-d3 (dl-Flurbiprofen-d3) | 1185133-81-6 | Flurbiprofen-d3 is the deuterium labelled form of Flurbiprofen. |
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V52633 | Flurbiprofen-d5 (dl-Flurbiprofen-d5) | 215175-76-1 | Flurbiprofen-d5 is the deuterium labelled form of Flurbiprofen. |
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V86078 | Fluvastatin sodium monohydrate (XU 62-320 monohydrate) | 201541-53-9 | |
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V56433 | Formoxanthone A | 869880-32-0 | Formoxanthone A is a compound that causes apoptosis and can significantly reduce the viability of HeLa cells at 25 μM. |
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V52085 | FOXO4-DRI | 2460055-10-9 | FOXO4-DRI is a cell-permeable (penetrable) peptide antagonist that blocks the interaction between FOXO4 and p53. |
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V52084 | FPA-124 | 902779-59-3 | FPA-124, a cell-permeable (penetrable) copper complex, is a selective Akt inhibitor (antagonist) with IC50 of 0.1 μM and interacts with the protein homology (PH) domain and kinase domain of Akt. |
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V54992 | Frexalimab (SAR441344; INX-021) | 2515463-86-0 | Frexalimab (SAR441344; INX-021) is a monoclonal antibody (mAb) targeting CD40 ligand (CD40L). |
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V52078 | FSEN1 | 862808-01-3 | FSEN1 is a potent, noncompetitive inhibitor of FSP1 with IC50 of 313 nM. |
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V52077 | FUBP1-IN-2 | 1242862-71-0 | FUBP1-IN-2 (compound 9) is a potent inhibitor of FUBP1 (far upstream binding protein 1). |
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V54939 | Furowanin A | 911004-72-3 | Furowanin A is a flavonoid with antitumor effects. |
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V2774 | FX1 | 1426138-42-2 | FX1 is a potent and specific inhibitor of the BCL6 (B cell lymphoma 6) with an IC50of approximately 35 μM. |
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V52620 | Galanthamine-d6 (galantamine d6) | 1128109-00-1 | Galanthamine-d6 is the deuterated form of Galanthamine. |
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V52619 | Galanthamine-O-methyl-d3 (galantamine d3) | 1279031-09-2 | Galanthamine-O-methyl-d3 is the deuterated form of Galanthamine. |
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V34782 | Gallic acid hydrate (gallic acid-hydrate; 3,4,5-Trihydroxybenzoic acid hydrate) | 5995-86-8 | Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound that can inhibit the free radical scavenging effect of cyclooxygenase-2 (COX-2). |
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V52599 | Gallic acid-d2 (3,4,5-Trihydroxybenzoic acid-d2) | 294660-92-7 | Gallic acid-d2 is the deuterated form of Gallic acid. |
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V34799 | Ganoderic acid DM (Ganoderic acid DM) | 173075-45-1 | Ganoderic acid DM is a natural triterpene extracted from Ganoderma lucidum and can induce DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. |
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V54860 | Ganoderic acid Mf (GA-Mf) | 108026-94-4 | Ganoderic acid Mf is an antitumor triterpenoid. |
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V34802 | Ganoderic acid Mk (GA-Mk) | 110024-14-1 | Ganoderic acid Mk (GA-Mk) is a triterpene acid extracted from Ganoderma lucidum mycelium. |
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