Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52013 | HBDDE | 154675-18-0 | HBDDE, an analogue of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor (antagonist) with IC50s of 43 μM and 50 μM, respectively. |
|
V51998 | HDAC-IN-50 | 2653339-26-3 | HDAC-IN-50 is a potent, orally bioactive dual (bifunctional) inhibitor of FGFR and HDAC, with IC50s of 0.18, 1.2, 0.46, and 1.4 for FGFR1, FGFR2, FGFR3, FGFR4, HDAC1, HDAC2, HDAC6, and HDAC8 respectively. |
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V54867 | HDAC-IN-59 | 2944459-43-0 | HDAC-IN-59 (compound 13a) is a potent inhibitor of histone deacetylase (HDAC). |
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V54871 | HDAC-IN-60 | 2944459-58-7 | HDAC-IN-60 (compound 21a) is a potent inhibitor of histone deacetylase (HDAC). |
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V54866 | HDAC-IN-63 | 2920046-95-1 | HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50= 0.844 and 30.0 nM for FLT3 and HDAC1, respectively). |
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V54877 | HDAC/JAK/BRD4-IN-1 | 2755325-84-7 | HDAC/JAK/BRD4-IN-1(compound 25ap) is a potent HDAC/JAK/BRD4 triple inhibitor. |
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V35067 | Hederacolchiside A1 (leather leaf hedera saponin A1) | 106577-39-3 | Hederacolchiside A1 is extracted from Pulsatilla vulgaris and causes apoptosis by regulating the PI3K/Akt/mTOR signaling pathway, thereby inhibiting the proliferation of tumor cells. |
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V34684 | Hematoporphyrin monomethyl ether | 148471-91-4 | Hematoporphyrin monomethyl ether is a second-generation porphyrin photosensitizer with the characteristics of single form, high singlet oxygen yield, high selectivity, and low toxicity. |
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V51992 | HEMTAC CDK4/6 degrader 1 | 2821803-61-4 | HEMTAC CDK4/6 degrader 1 is a PROTAC linked by HSP90 ligand and CDK4/6, with a Kd of 35.7 μM. |
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V84498 | Hepatoprotective agent-1 | 1225971-07-2 | |
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V84769 | Hepatoprotective agent-2 | 74873-41-9 | |
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V1996 | Hesperidin (Hesperetin 7-rutinoside) | 520-26-3 | Hesperidin (HP, Hesperetin 7-rutinoside) is a naturally occuring bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. |
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V34743 | Hirudin | 8001-27-2 | Hirudin is a thrombin inhibitor (antagonist) with anticoagulant properties. |
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V51989 | HIV Protease Substrate 1 | 223769-59-3 | HIV Protease Substrate 1 is an exogenous HIV protease substrate that may be utilized to study the enzymatic activity of HIV protease. |
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V51986 | HIV-1 inhibitor-53 | 2883496-10-2 | HIV-1 inhibitor-53 is a dual HIV-1 protease and reverse transcriptase inhibitor. |
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V54911 | HJC0152 free base | 1420290-88-5 | HJC0152 (free base) is an orally bioactive and potent STAT3 inhibitor. |
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V51982 | HJC0416 hydrochloride | 2415263-08-8 | HJC0416 HCl is a potent orally bioactive STAT3 inhibitor (antagonist) with stronger anti-cancer activity than Stattic . |
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V51981 | HKPao (Hunter-killer peptide ao) | 859216-15-2 | HKPao (Hunter-killer peptide ao) is a biologically active peptide. |
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V51979 | HLI373 dihydrochloride | 1782531-99-0 | HLI373 di-HCl is a potent Hdm2 inhibitor. |
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V30560 | hnRNPK-IN-1 | 2313528-04-8 | hnRNPK-IN-1 is a heterogeneous ribonucleoprotein K (hnRNPK) binding ligand with Kds of 4.6 μM and 2.6 μM measured by SPR and MST, respectively. |
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