Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V54908 | Immunosuppressant-1 | 1224571-03-2 | Immunosuppressant-1 (Compound 31) inhibits anti-CD3/anti-CD28 costimulated T cell proliferation/growth. |
|
V2712 | Importazole | 662163-81-7 | Importazole,a 2,4-diaminoquinazoline identified from a FRET-based, high-throughput small molecule screen for compounds that interfere with the interaction between RanGTP and importin-β, is a small molecule inhibitor of the transport receptor importin-β that specifically blocks importin-β-mediated nuclear import. |
|
V52541 | Indinavir-d6 (MK-639-d6 (free base); L-735524-d6 (free base)) | 185897-02-3 | Indinavir-d6 is the deuterium labelled form of Indinavir. |
|
V54997 | Inezetamab | 2568264-76-4 | Inezetamab is a bispecific anti-CD40 and anti-MSLN IgG1 monoclonal antibody (mAb). |
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V51945 | Inuviscolide | 63109-30-8 | Inuviscolide is an inducer of apoptosis. |
|
V55011 | Iratumumab (MDX-060) | 640735-09-7 | Iratumumab (MDX-060) is a human anti-CD30 IgG1κ monoclonal antibody (mAb). |
|
V56385 | Irbesartan-d6-1 (irbesartan-d6-1; irbesartan-d6-1) | 2375621-21-7 | Irbesartan-d6-1 is the deuterated form of Irbesartan. |
|
V33982 | Isatuximab | 1461640-62-9 | Isatuximab is a monoclonal antibody (mAb) that targets the transmembrane receptor and ectoenzyme CD38, a protein highly expressed in hematological malignancies such as multiple myeloma. |
|
V51940 | Iscalimab (CFZ-533; OM11-62MF) | 2031153-61-2 | Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody (mAb) targeting CD40 (KD: 0.3 nM). |
|
V51938 | Isoangustone A | 129280-34-8 | Isoangustone A is an anticancer and anti~inflammatory agent. |
|
V51936 | Isochamaejasmin | 93859-63-3 | Isochamaejasmin is a biflavonoid with anticancer, antiplasmodial, and insecticidal activities. |
|
V51934 | Isodispar B | 98192-64-4 | Isodispar B is an anticancer agent that suppresses the proliferation/growth of nasopharyngeal carcinoma and breast cancer cells and causes apoptosis. |
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V54903 | Isoharringtonine | 26833-86-3 | Isoharringtonine is a naturally occurring alkaloid isolated from Cephalotaxus koreana Nakai. |
|
V53596 | Isojacareubin | 50597-93-8 | Isojacareubin can be extracted from Hypericum japonicum. |
|
V29644 | Isoliensinine | 6817-41-0 | Isoliensinine is a bisbenzylisoquinoline alkaloid found in the seed embryo of Nelumbo nucifera. |
|
V86014 | Ivarmacitinib sulfate (SHR0302 sulfate) | 1639419-51-4 | |
|
V51928 | IVHD-valtrate | 28325-56-6 | IVHD-valtrate is an active Valeriana jatamansi analogue that has inhibitory effects on human ovarian cancer cells both in vivo and in vitro. |
|
V85516 | JAB-2485 | 2899209-55-1 | |
|
V51926 | JAK2/FLT3-IN-1 TFA | 2928093-29-0 | JAK2/FLT3-IN-1 (TFA) is an orally bioactive dual JAK2/FLT3 inhibitor (antagonist) with IC50s of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3 respectively. |
|
V84862 | JC-010a | 2565765-13-9 |
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