Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51914 | Justicidin B (Acanthide B) | 17951-19-8 | Justicidin B is a potent anticancer lignan and proapoptotic agent. |
|
V51909 | Kauran-16,17-diol (ent-Kauran-16β,17-diol) | 16836-31-0 | Kauran-16,17-diol (ent-Kauran-16β,17-diol) is a natural diterpene compound with anti-tumor and apoptosis-inducing activity. |
|
V51907 | KB02-SLF | 2384184-40-9 | KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). |
|
V51905 | Kdo2-Lipid A ammonium | 1246298-62-3 | Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) whose endotoxin activity is equivalent to that of LPS. |
|
V52567 | Ketoprofen-d3 (RP-19583-d3) | 159490-55-8 | Ketoprofen-d3 is the deuterium labelled form of Ketoprofen. |
|
V56415 | Ketoprofen-d4 (RP-19583-d4) | 1219805-29-4 | Ketoprofen-d4 is the deuterium labelled form of Ketoprofen. |
|
V56441 | Kevetrin hydrochloride-13C2,15N3 | 2300178-72-5 | Kevetrin ( HCl)-13C2,15N3 is a 13C (carbon 13) and 15N (nitrogen 15) labelled Kevetrin ( HCl). |
|
V23241 | Kinetin Riboside (N6-Furfuryladenosine) | 4338-47-0 | Kinetin Riboside,an analotg of cytokinin,is a potent activator of the Parkinson's Disease-associated PTEN-induced Putative Kinase 1 (PINK1), and acts independently from mitochondrial depolarization. |
|
V51899 | KIRA9 | 2922507-65-9 | KIRA9 is a potent inhibitor of IRE1 (IC50=4.8 μM in INS-1 cells). |
|
V54351 | Koaburaside | 41653-73-0 | Koaburaside is a naturally occurring compound with cytoprotective and anti-inflammatory effects. |
|
V54836 | Koenimbine | 21087-98-9 | Koenimbine is an anticancer agent obtained from the leaves and fruits of Murraya koenigii. |
|
V51895 | KTX-582 | 2573298-13-0 | KTX-582 is a potent IRAK4 degrader with DC50s of 4 nM and 5 nM for IRAK4 and Ikaros, respectively. |
|
V51894 | Kuguaglycoside C | 1041631-93-9 | Kuguaglycoside C is a triterpene glycoside that can be extracted from the leaves of Momordica charantia. |
|
V51893 | Kurarinol (matrine alcohol) | 855746-98-4 | Kurarinol is a flavanone found in Sophora flavescens roots. |
|
V51892 | Kusunokinin ((-)-Kusunokinin) | 58311-20-9 | Kusunokinin ((-)-Kusunokinin) is a naturally occurring compound extracted from P. |
|
V51890 | KWCN-41 | 2913223-17-1 | KWCN-41 is a selective RIPK1 kinase inhibitor (antagonist) with IC50 of 88 nM. |
|
V56451 | L-Cystine-3,3'-13C2 (L-Cystine-13C2) | 2483736-13-4 | L-Cystine-3,3'-13C2 is 13C (carbon 13)-labeled L-Cystine. |
|
V52805 | L-Cystine-d4 (L-cystine d4) | 1192736-38-1 | L-Cystine-d4 is the deuterated form of L-Cystine. |
|
V52718 | L-Glutamic acid-1-13C (L-glutamic acid 1-13C) | 81201-99-2 | L-Glutamic acid-1-13C is a 13C (carbon 13)-labeled L-Glutamic acid. |
|
V56408 | L-Glutamic acid-13C (L-glutamic acid 13C) | 115473-51-3 | L-Glutamic acid-13C is a 13C (carbon 13)-labeled L-Glutamic acid. |
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