Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52609 | Lidocaine-d10 (lidocaine d10) | 851528-09-1 | Lidocaine-d10 is the deuterium labelled form of Lidocaine. |
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V56402 | Lidocaine-d10 hydrochloride (lidocaine d10 hydrochloride (hydrochloride)) | 1189959-13-4 | Lidocaine-d10 ( HCl) is the deuterated form of Lidocaine HCl. |
|
V51859 | Lilotomab (HH1) | 1453362-55-4 | Lilotomab (HH1) is a murine anti-CD37 monoclonal antibody (mAb). |
|
V55000 | Linvoseltamab (REGN5458) | 2408319-25-3 | Linvoseltamab is a bispecific antibody targeting BCMA (TNFRSF17) and CD3 epsilon. |
|
V51856 | Liproxstatin-1 hydrochloride | 2250025-95-5 | Liproxstatin-1 HCl is a potent ferroptosis inhibitor that can suppress ferroptotic cell death (IC50=22 nM). |
|
V51855 | Lirentelimab (AK002; Anti-Siglec-8 Reference Antibody (lirentelimab)) | 2283348-97-8 | Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody (mAb) targeting sialic acid-bound Ig-like lectin 8 (SIGLEC8). |
|
V51854 | Liriodenine (Spermatheridine; VLT045) | 475-75-2 | Liriodenine (Spermatheridine; VLT045) is extracted from the plant Mitrephora sirikitiae and has anti-neoplastic activity. |
|
V34788 | Lithium chloride hydrate (hydrate/monohydrateortrihydrate) | 85144-11-2 | Lithium chloride hydrate is an orally bioactive mood stabilizer that is a potent viral inhibitor and immune modulator. |
|
V34751 | Lithocholic acid-d4 (3α-Hydroxy-5β-cholanic acid-d4) | 83701-16-0 | Lithocholic acid-d4 is deuterium-labeled lithocholic acid, a toxic secondary bile acid. |
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V51853 | Lobetyol | 136171-87-4 | Lobetyol is a natural compound extracted from Lobelia chinensis. |
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V51850 | Loncastuximab tesirine (Loncastuximab tesirine-lpyl; ADCT-402) | 1879918-31-6 | Loncastuximab tesirine is a human cluster differentiation 19 (CD19)-targeting antibody-active molecule conjugate (ADC). |
|
V6203 | LPd peroxida probe (lipid peroxidation green probe) | 1448846-35-2 | The LPd peroxida probe, a marker of ferroptosis, is a useful fluorescent probe for studying the role of lipid peroxidation in various cellular pathophysiology. |
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V51839 | Lucatumumab (HCD122) | 903512-50-5 | Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody (mAb) that blocks the CD40/CD40L-mediated signaling pathway. |
|
V51837 | Lusianthridin | 87530-30-1 | Lusianthridin is a natural compound from Dendrobium venustum that has anti-migration effects. |
|
V51836 | Luxeptinib (CG-806) | 1616428-23-9 | Luxeptinib (CG-806) is an orally bioactive, reversible, first-in-class, non-covalent, potent pan-FLT3/pan-BTK inhibitor. |
|
V54943 | m-Se3 | 2829939-44-6 | m-Se3 is a potent and specific c-MYC transcription inhibitor that can inhibit tumor growth and has anti-cancer activity. |
|
V51832 | M190S | 2578300-07-7 | M109S is a novel small molecule that protects cells from mitochondria-dependent apoptosis both in vitro and in vivo. |
|
V51829 | M47 | 890808-56-7 | M47 is a small molecule that selectively destabilizes cryptochrome 1 (CRY1) and increases CRY1 degradation in the nucleus. |
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V51828 | M50054 | 54135-60-3 | M50054 is a potent apoptosis inhibitor. |
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V54952 | M867 | 680999-39-7 | M867 is a selective and reversible caspase-3 inhibitor (antagonist) with IC50 of 1.4 nM and a Ki of 0.7 nM. |
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