Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51827 | MA242 free base | 1049704-17-7 | MA242 free base is a specific dual (bifunctional) inhibitor of MDM2 and NFAT1. |
|
V55023 | Maceneolignan A | 1967042-42-7 | Maceneolignan A is a naturally occurring compound extracted from the arils of Myristica nigrum (Myristicaceae). |
|
V51823 | Malabaricone B | 63335-24-0 | Malabaricone B is a naturally occurring plant phenolic substance and an orally bioactive α-glucosidase inhibitor (antagonist) with IC50 of 63.7 µM. |
|
V52914 | Malachite green hemioxalate | 2437-29-8 | Malachite green hemioxalate is a triphenylmethane dye that may be utilized to detect phosphate release in enzymatic reactions. |
|
V51819 | Malvidin chloride (Syringidin) | 643-84-5 | Malvidin (chloride) is a bioactive compound extracted from grapes. |
|
V51817 | Malvidin-3-galactoside chloride | 30113-37-2 | Malvidin-3-galactoside chloride is an anthocyanin monomer that induces cell cycle arrest and apoptosis in hepatocellular carcinoma (HCC). |
|
V51804 | MC2590 | 2284460-01-9 | MC2590 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. |
|
V51805 | MC2625 | 1776116-75-6 | MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. |
|
V51802 | MC4033 | 28532-21-0 | MC4033 is a selective, reversible inhibitor of lysine acetyltransferase 8 (KAT8) with IC50 of 12.1 μM. |
|
V54923 | Mcl-1 antagonist 1 | 2376775-05-0 | Mcl-1 antagonist 1 is a Mcl-1 antagonist. |
|
V54926 | Mcl-1 inhibitor 12 | 2445466-24-8 | Mcl-1 inhibitor 12 (Example 10) is an MCL-1 inhibitor (Ki: 0.22 nM). |
|
V54933 | Mcl-1 inhibitor 13 | 2445466-06-6 | Mcl-1 inhibitor 13 (Example 9) is an MCL-1 inhibitor (Ki: 8.2 nM). |
|
V51801 | Mcl-1 inhibitor 9 | 1883727-31-8 | Mcl-1 inhibitor 9 (example 2) is a myeloid cell leukemia 1 (Mcl-1) inhibitor (antagonist) with IC50 of 0.21889 nM and has anti-tumor activity. |
|
V53390 | MCL-1/BCL-2-IN-1 | 2493256-46-3 | MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and specific inhibitor of Mcl-1 and Bcl-2 with IC50 of 4.45 and 3.18 μM, respectively. |
|
V53305 | MCL-1/BCL-2-IN-3 | 2163793-55-1 | MCL-1/BCL-2-IN-3 (Compound 2) is a potent and specific inhibitor of Mcl-1 and Bcl-2 with IC50 of 5.95 and 4.78 μM, respectively. |
|
V52970 | MCL-1/BCL-2-IN-4 | 2163793-56-2 | MCL-1/BCL-2-IN-4 (Compound 7) is a potent and specific inhibitor of Mcl-1 and Bcl-2. |
|
V51800 | MD-222 | 2136246-72-3 | MD-222 is a first-of-its-kind, highly efficient PROTAC-based MDM2 degrader. |
|
V20631 | MDM2-IN-21 | 939981-88-1 | MDM2-IN-21 is a potent MDM2 inhibitor. |
|
V51799 | MDM2-p53-IN-16 | 1917350-09-4 | MDM2-p53-IN-16 is an inhibitor (blocker/antagonist) of the MDM2-p53 complex and dissociates the human MDM2-p532 complex with IC50 of 4.3 nM. |
|
V54969 | MDM2/XIAP-IN-3 | 2925583-17-9 | MDM2/XIAP-IN-3 (compound 3e) is a dual MDM2/XIAP inhibitor. |
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