Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
![]() |
V40980 | Prexasertib dimesylate (LY2606368 dimesylate) | 1234015-58-7 | Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive, second-generation cell cycle checkpoint kinase 1 (CHK1) inhibitor (antagonist) with a Ki of 0.9 nM and IC50 of <1 nM. |
![]() |
V30718 | Procyanidin C1 | 37064-30-5 | Procyanidin C1 (PCC1) is an orally bioactive naturally occurring polyphenol that can cause DNA damage, cell cycle arrest, and cause apoptosis. |
![]() |
V53670 | Propylparaben sodium (propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium) | 35285-69-9 | Propylparaben sodium (Propyl parahydroxybenzoate sodium) is an antimicrobial preservative produced by plants and bacteria. |
![]() |
V56243 | Propylparaben-d4 (propyl parahydroxybenzoate-d4; Propyl parahydroxybenzoate-d4; Propyl 4-hydroxybenzoate-d4) | 1219802-67-1 | Propylparaben-d4 is the deuterated form of Propylparaben. |
![]() |
V54809 | Prostaglandin A2 (PGA2; Medullin) | 13345-50-1 | Prostaglandin A2 (PGA2), the endogenously produced metabolite of PGE2 in humans, is an antineoplastic/anticancer agent. |
![]() |
V54921 | PROTAC Bcl-xL degrader-3 | 2471970-60-0 | PROTAC Bcl-xL degrader-3 is an effective PROTAC Bcl-xL degrader (For more details, check and find WO2020163823A2, compound 2). |
![]() |
V52909 | PROTAC Bcl2 degrader-1 | 2378801-85-3 | PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which is effective and specific by introducing pomalidomide, the ligand of E3 ligase cereblon, into the Mcl-1/Bcl-2 dual (bifunctional) inhibitor Nap-1. |
![]() |
V40978 | PROTAC BRD4 Degrader-16 | 2585561-36-8 | PROTAC BRD4 Degrader-16 is a potent PROTAC BRD4 degrader with IC50s of 34.58 nM (BRD4 (BD1)) and 40.23 nM (BRD4 (BD2)). |
![]() |
V40977 | PROTAC BRD4 Degrader-17 | 2585561-49-3 | PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 degrader with IC50s of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). |
![]() |
V40595 | PROTAC EGFR degrader 6 | 2409793-28-6 | PROTAC EGFR degrader 6 is a PROTAC EGFR degrader that can effectively degrade EGFRDel19 in HCC827 cells with DC50 of 45.2 nM. |
![]() |
V34677 | PROTAC GPX4 degrader-1 | 2916433-81-1 | PROTAC GPX4 degrader-1 (DC-2) is a PROTAC protein degrader of GPX4 with DC50 of 0.03 μM in HT1080 cells. |
![]() |
V40398 | PROTAC HDAC6 degrader 1 | 2785404-76-2 | PROTAC HDAC6 degrader (Compound A6) is a potent and specific degrader of PROTAC HDAC6 with DC50 of 3.5 nM. |
![]() |
V53082 | PROTAC RIPK degrader-2 | 1801547-16-9 | PROTAC RIPK degrader-2 is a von Hippel-Lindau-based non-peptide PROTAC that targets the serine-threonine kinase RIPK2 and is selective for the degradation of RIPK2. |
![]() |
V40115 | PROTAC RIPK degrader-6 | 2089205-64-9 | PROTAC RIPK degrader-6 (example 1) is an effective RIP Kinase degrader of the PROTAC class based on Cereblon ligand. |
![]() |
V40084 | PROTAC-O4I2 | 2785323-62-6 | PROTAC-O4I2 is a PROTAC targeting splicing factor 3B1 (SF3B1). |
![]() |
V39741 | Psalmotoxin 1 (PcTx1; Psalmopoeus cambridgei toxin-1) | 880107-52-8 | Psalmotoxin 1 (PcTx1) is a protein toxin that binds to the subunit-subunit interface of acid-sensitive ion channel 1a (ASIC1a). |
![]() |
V3680 | PTC-028 | 1782970-28-8 | PTC-028 is a potent and orally bioavailable compound that decreases BMI-1levels by posttranslational modification. |
![]() |
V39673 | Pygenic acid A (septic acid A) | 52213-27-1 | Pygenic acid A is a natural compound found in Prunella vulgaris. |
![]() |
V35011 | Pyridinium bisretinoid A2E TFA (A2E TFA) | 1821308-73-9 | Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore extracted from lipofuscin of the retinal pigment epithelium (RPE). |
![]() |
V39523 | Pyroxamide | 382180-17-8 | Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. |