Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V37734 | S65487 hydrochloride (VOB560 hydrochloride) | 1644543-95-2 | S65487 (VOB560) HCl is a potent and specific Bcl-2 inhibitor and the precursor of S55746. |
|
V37695 | S65487 sulfate (VOB560 sulfate) | 2416937-01-2 | S65487 (VOB560) sulfate is a potent and specific Bcl-2 inhibitor and the precursor of S55746. |
|
V37657 | SAHA-OH | 2857098-30-5 | SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM) with 10-47 times selectivity for HDAC6 compared to HDAC1, 2, 3 and 8. |
|
V52964 | Salicylic acid-d6 (Salicylic acid-D6; 2-Hydroxybenzoic acid-d6) | 285979-87-5 | Salicylic acid-d6 is a deuterated form of Salicylic acid. |
|
V37633 | Sandacanol | 28219-61-6 | Sandacanol is a specific agonist of the olfactory receptor (OR10H1). |
|
V54977 | Sanggenol L | 329319-20-2 | Sanggenol L induces caspase-dependent and -independent apoptosis in melanoma skin cancer cells. |
|
V37541 | SB 202190 hydrochloride | 350228-36-3 | SB 202190 HCl is a selective p38 MAPK inhibitor (antagonist) with IC50s of 50 nM and 100 nM for p38α and p38β2 inhibition, respectively. |
|
V28778 | SC144 hydrochloride | 917497-70-2 | SC144 hydrochloride (HCl) is a first-in-class, potent and orally bioavailable small-molecule gp130 inhibitor; it inhibits cell growth in a panel of human ovarian cancer cell lines with IC50 in a submicromolar range. |
|
V14540 | Schizandrin C | 61301-33-5 | Schisandrin C (Schizandrin-C) is a phytochemical lignan extracted from Schisandra chinensis. |
|
V37464 | Scoulerine ((-)-Sculerine; Discretamine) | 6451-73-6 | Scoulerine ((-)-Sculerine) is a potent antimitotic compound. |
|
V37348 | SCR130 | 2377858-38-1 | SCR130 is a SCR7-based inhibitor of DNA nonhomologous end joining (NHEJ). |
|
V54873 | Scutebarbatine A ((-)-Scutebarbatine A) | 176520-13-1 | Scutebarbatine A suppresses the proliferation/growth of liver cancer cells and triggers apoptosis of liver cancer cells by activating MAPK and endoplasmic reticulum stress. |
|
V52941 | SDZ 224-015 | 161511-45-1 | SDZ 224-015 is an orally bioactive inhibitor of IL-1β converting enzyme and caspase-1. |
|
V36753 | Se-Methylselenocysteine hydrochloride (L-Se-methylselenocysteine; Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride) | 863394-07-4 | Se-Methylselenocysteine HCl, the precursor of methylselenium, has potent cancer chemopreventive and anti-oxidant effect. |
|
V37087 | Semapimod (CNI-1493 free base; CPSI-2364) | 352513-83-8 | Semapimod is an inhibitor (blocker/antagonist) of proinflammatory cytokine production and inhibits TNF-α, IL-1β and IL-6. |
|
V37021 | Seribantumab (SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody) | 1334296-12-6 | Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody (mAb) targeting HER3. |
|
V34756 | Sertaconazole (Sertaconazole; FI7056 free base) | 99592-32-2 | Sertaconazole (FI7056 free base) is a topical broad-spectrum antifungal agent that exerts anti-inflammatory activity through activation of the p38-COX-2-PGE 2 pathway. |
|
V54914 | Shizukaol D | 142279-42-3 | Shizukaol D is a dimeric sesquiterpene extracted from Chloranthus serratus. |
|
V36626 | SHP2 protein degrader-1 | 2624181-69-5 | SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. |
|
V53721 | Sideroxylin | 3122-87-0 | Sideroxylin is a C-methylated flavonoid extracted from Callistemon lanceolatus and has anti-bacterial effect against Staphylococcus aureus. |
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