Ferroptosis

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

+MORE

Ferroptosis

A non-apoptotic type of controlled cell death is ferroptosis. It differs from other types of controlled cell death, like apoptosis and necroptosis. Large-scale lipid peroxidation, which is a hallmark of ferroptosis, can be prevented by lipophilic antioxidants or iron chelators. Ferroptosis inducers can be categorized into two groups based on their mechanisms: (1) inhibitors of cystine import via system xc (such as Erastin), which lead to the depletion of glutathione (GSH), and (2) covalent inhibitors of glutathione peroxidase 4 (GPX4), such as (1S, 3R)-RSL3.Both compound classes ultimately lead to a loss of GPX4 activity, which is followed by increased levels of lipid reactive oxygen species (ROS) and eventual cell death. GPX4 reduces lipid hydroperoxides using GSH as a co-substrate.

Iron and ROS are required for the regulated cell death (RCD) process known as ferroptosis. Misregulated ferroptosis has been linked to a number of physiological and pathological processes, such as T-cell immunity, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, neurotoxicity, and the death of cancer cells.

Ferroptosis related products

Cat No.	Product Name	CAS No.	Product Description
V76017	icFSP1	1115910-36-5	icFSP1 is a potent inhibitor of ferroptosis suppressor protein-1 (FSP1).
V39586	iFSP1	150651-39-1	iFSP1 is a novel and glutathione-independent inhibitor offerroptosis suppressor protein 1(FSP1) (AIFM2) with an EC50 of 103 nM.
V76833	L-Buthionine-(S,R)-sulfoximine hydrochloride (L-Buthionine sulfoximine hydrochloride; L-BSO hydrochloride)		L-Buthionine-(S,R)-sulfoximine HCl is a cell-permeable (penetrable), potent, fast-acting, orally bioactive, irreversible G-glutamate cysteine synthetase (γ- glutamylcysteine synthetase) inhibitor, which can reduce intracellular glutathione levels.
V105568	Lapatinib-d4 tosylate	2749856-05-9	Lapatinib-d4 (GW572016-d4) mesylate is the deuterated version of lapatinib (mesylate).
V80533	Lapatinib-d7 dihydrochloride (GW572016-dd7 (dihydrochloride); GW2016-dd7 (dihydrochloride))		Lapatinib-d7 (di-HCl) is the deuterated form of Lapatinib di-HCl.
V105639	Levobupivacaine-d9 hydrochloride		Levobupivacaine-d9 ((S)-(-)-Bupivacaine-d9) hydrochloride is the deuterated version of levobupivacaine (hydrochloride).
V79062	Lovastatin-d9 (Lovastatin d9)		Lovastatin-d9 is the deuterium labelled form of Lovastatin.
V50961	MMRi-62	352693-80-2	MDM4-degrader and ferroptosis/apoptosis inducer
V107064	Monosialoganglioside GM3 (bovine)	54827-14-4	Monosialoganglioside GM3 (bovine) is a monosialoganglioside that is an inhibitor of VEGFR2 and Akt.
V80908	NC-R17		NC-R17 is an RSL3-based non-covalent GPX4 degrader that participates in ferroptosis.
V2338	SRS11-92	1467047-25-1	SRS11-92 is a Ferrostatin-1 (Fer-1) analog and a potent inhibitor of ferroptosis.
V4269	UAMC-3203	2271358-64-4	UAMC-3203 (UAMC3203) is a novel and selectiveFerroptosisinhibitor with anIC50value of 12 nM.
V4440	UAMC-3203 HCl	2271358-65-5	UAMC-3203HCl(UAMC3203 hydrochloride) is a novel, potent, and selectiveFerroptosisinhibitor (IC50value =12 nM) with higher solublility and anti-inflammatory/antioxidant effects.
V61783	viFSP1	951945-67-8	viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells.
V76347	W1131 TFA		W1131 TFA is a potent STAT3 inhibitor that cancause ferroptosis.
V73488	YL-939	3023925-68-7	YL-939 is a potent inhibitor of ferroptosis.
V30161	Deferasirox Fe3+ chelate	554435-83-5	Deferasirox Fe3+ chelate is a novel, oral and potent iron chelator (chelating agent) that was rationally designed.
V34159	NADPH tetracyclohexanamine	100929-71-3	NADPH tetracyclohexanamine (NADPH;β-NADPH; TPNH), thetetracyclohexanamine salt form of NADPH (β-Nicotinamide adenine dinucleotide phosphate),is a potent cofactor and biological reducing agent, alsoan electron donor and a cofactor for nitric oxide synthetase.