Ferroptosis

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Ferroptosis

A non-apoptotic type of controlled cell death is ferroptosis. It differs from other types of controlled cell death, like apoptosis and necroptosis. Large-scale lipid peroxidation, which is a hallmark of ferroptosis, can be prevented by lipophilic antioxidants or iron chelators. Ferroptosis inducers can be categorized into two groups based on their mechanisms: (1) inhibitors of cystine import via system xc (such as Erastin), which lead to the depletion of glutathione (GSH), and (2) covalent inhibitors of glutathione peroxidase 4 (GPX4), such as (1S, 3R)-RSL3.Both compound classes ultimately lead to a loss of GPX4 activity, which is followed by increased levels of lipid reactive oxygen species (ROS) and eventual cell death. GPX4 reduces lipid hydroperoxides using GSH as a co-substrate.

Iron and ROS are required for the regulated cell death (RCD) process known as ferroptosis. Misregulated ferroptosis has been linked to a number of physiological and pathological processes, such as T-cell immunity, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, neurotoxicity, and the death of cancer cells.

Ferroptosis related products

Cat No.	Product Name	CAS No.	Product Description
V103322	(1R,3R)-Ferroptosis inducer-1	2375357-97-2	(1R,3R)-Ferroptosis is an isomer of ferroptosis inducer-1.
V120405	(1R,3R)-RSL3	1219810-15-7
V122302	(Z)-GW 441756	504433-24-3	(Z)-GW 441756 is a hepatocyte nuclear factor 4α (HNF4α) activator with an EC50 of 9.2 μM and a Ka of 4.6 μM in the human system.
V118449	1,4-Naphthoquinone-NH-C2-NH-Trolox		1,4-Naphthoquinone-NH-C2-NH-Trolox is a neuroprotective compound of Trolox and vitamin K that can cross the blood-brain barrier.
V109452	3-Hydroxyindole	480-93-3	3-Hydroxyindole is a hydroxyindole compound with antioxidant activity that can inhibit the scavenging of DPPH and crocin.
V51332	Rosiglitazone-d3 (BRL-49653-d3)	1132641-22-5	deuterated form of Rosiglitazone
V122425	[Ru(phen)2(HMPIP)](PF6)2		[Ru(phen)2(HMPIP)](PF6)2 is an anti-tumor drug.
V118606	afi-FSP1-1	3072951-35-7	afi-FSP1-1 is an inhibitor of ferroptosis inhibitor protein 1 (FSP1) with a Ki value of 0.283 μM.
V128855	Anion transporter-4		Anion transporter-4 is a small anion transporter that can induce microtubule degradation and mitochondrial dysfunction.
V129131	anti-NSCLC agent-2	3063042-21-4	anti-NSCLC agent-2 is an inhibitor of SLC7A11 and GPX4 that reduces the expression of key regulators of ferroptosis, SLC7A11 and GPX4.
V129160	anti-TNBC agent-15		anti-TNBC agent-15 is a platinum (IV) complex with activity against triple-negative breast cancer.
V79509	Anticancer agent 154		Anticancer agent 154 (Compound 8h) increases levels of reactive oxygen species and causes mitochondrial damage.
V128965	Anticancer agent 272		Anticancer agent 272 is an anticancer drug.
V128981	Anticancer agent 309		Anticancer agent 309 is an anticancer agent and G-quadruplex binder with Kd values of 2.46 μM and 1.61 μM for c-Myc G4 and KRAS G4, respectively.
V129191	Antitumor agent-217		Antitumor agent-217 is a dual mitochondrial-targeted anticancer drug.
V129697	AX-53802	1008482-71-0	AX-53802 is a ferroptosis inducer that targets GPX4 with an IC50 value of 0.34 µM.
V129705	AY-4		AY-4 is a highly efficient PROTAC degrader that targets FTH1 (Kd = 3.17 nM).
V105417	BG11	3065877-52-0	BG11 induces the accumulation of Fe2+ and intracellular lipid peroxides, inducing ferroptosis.
V3193	CA3 (CIL-56)	300802-28-2	CA3 (also known as CIL56) is a novel and potent inhibitor ofYAP1/Teadtranscriptional activity.
V131019	CAR-2	3030055-40-1	CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LD).