The pathogenesis of a wide range of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases, has been linked to tumor necrosis factor (TNF), a key mediator of apoptosis as well as inflammation and immunity.
TNF- α is a homotrimer in solution and a 17-kDa protein with 157 amino acids. The gene is located on chromosome 6 in humans. Its soluble TNF-binding receptors play a major role in controlling its bioactivity. T lymphocytes, natural killer cells, and activated macrophages are the main producers of TNF-α. Numerous other cells, such as fibroblasts, smooth muscle cells, and tumor cells, are known to have lower expression. TNF- is produced in cells as pro-TNF (26 kDa), which is membrane-bound and is released after TNF-converting enzyme (TACE) cleaves its pro domain.
The two TNF receptors, TNF-R1 and TNF-R2, which are both members of the TNF receptor super-family, mediate many of the cellular responses brought on by TNF. Most cell types respond to TNF treatment by activating the transcription factor NF-B and MAP kinases like ERK, p38, and JNK. In some cases, apoptosis or necrosis may also be induced. However, TNFR1, also referred to as a death receptor, is primarily responsible for the induction of apoptosis or necrosis. Numerous cytokines and immune-regulatory proteins are induced as a result of NF-B and MAPK activation, which is crucial for many inflammatory responses.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51038 | Adalimumab beta (ABP-501) | 1446410-95-2 | anti-TNF-α monoclonal antibody |
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V77871 | Akt/NF-κB/MAPK-IN-1 | Akt/NF-κB/MAPK-IN-1 (compound 2m) is an orally bioactive NO inhibitor (IC50=7.70 μM) without obvious toxicity. | |
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V77782 | Anti-inflammatory agent 61 | Anti-inflammatory agent 61 (Compound 5b) is a potent anti-inflammatory agent. | |
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V78041 | Anti-Mouse 4-1BB Antibody (3H3) | Anti-Mouse 4-1BB Antibody is an anti-mouse 4-1BB IgG2a antibody inhibitor developed from host Rat. | |
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V85057 | BMS-561392 formate (DPC 333 formate) | 2922280-85-9 | |
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V76012 | Boserolimab (MK-5890) | 2444297-08-7 | Boserolimab (MK-5890) is a chimeric humanized IgG1κ antibody targeting the mouse signaling regulatory protein CD27. |
|
V51081 | Broussonin E | 90902-21-9 | anti-inflammatory agent |
|
V84623 | DBM 1285 dihydrochloride | 1782532-29-9 | |
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V79207 | DPP-4-IN-8 | DPP-4-IN-8 (compound 27) is a potent and specific DPP4 inhibitor (antagonist) with Ki of 0.96 μM. | |
|
V77066 | DRI-C21041 (DIEA) | DRI-C21041 DIEA is a CD40/CD40L interaction inhibitor (antagonist) with IC50 of 0.31 μM. | |
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V77055 | DSTYSLSSTLTLSK TFA | DSTYSLSSTLTLSK TFA is a human universal peptide that can be used for quantitative detection of infliximab. | |
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V74915 | EM-163 | 1206480-93-4 | EM-163 is a synthetic BB-Loop analog. |
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V76011 | Evunzekibart (ATOR-1017) | 2639688-77-8 | Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. |
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V76013 | Exlinkibart (LVGN-6051) | 2642171-64-8 | Exlinkibart (LVGN-6051) targets TNFRSF9 and is an IgG1κ antibody humanized through complementarity determining region (CDR) grafting technology. |
|
V77017 | Fisetin quarterhydrate (fisetin) | Fisetin quarterhydrate is a natural flavonol found in many fruits and vegetables that has multiple benefits such as antioxidant, anti-cancer, and neuro-protection effects. | |
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V76924 | HMGB1-IN-1 | HMGB1-IN-1 (compound 6) displays strong NO inhibition in RAW264.7 cells with IC50 of 15.9 ± 0.6 μM. | |
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V51554 | Isodorsmanin A | 118266-99-2 | anti-inflammatory agent |
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V76829 | LEESGGGLVQPGGSMK acetate | LEESGGGLVQPGGSMK acetate, a proteolytic peptide that is a component of Infliximab, may be utilized in the quantitative analysis of Infliximab. | |
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V80550 | LEESGGGLVQPGGSMK TFA | LEESGGGLVQPGGSMK TFA, a proteolytic peptide, is a component of Infliximab and can be used for quantitative analysis of Infliximab. | |
|
V76822 | Licaminlimab (OCS-02) | Licaminlimab (OCS-02) is a single-chain anti-TNF alpha antibody fragment. |
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