Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.
By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V102539 | 4-Oxofenretinide-d4 | 2991099-34-2 | 4-Oxo-4-HPR-d4 is a deuterium-labeled 4-oxo-4-HPR. |
|
V106542 | 4-Thiouracil | 591-28-6 | 4-Thiouracil is a sulfur nucleobase with cytostatic properties. |
|
V107113 | 5-Acetamide-Butenolide | 16275-44-8 | 5-Acetamide-butenolide is a mycotoxin with pro-oxidant activity found in Fusarium spp. |
|
V72910 | 5-Hydroxyoxindole | 3416-18-0 | 5-Hydroxyoxindole is a structural analog of uric acid. |
|
V5169 | Methyl aminolevulinate HCl (LS-187769) | 79416-27-6 | Methyl-5-aminolevulinate HCl, a prodrug that is metabolised to Protoporphyrin IX (sensitizer) used in photodynamic therapy, is a used as a topical cream formulation which contains the hydrochloride salt of methyl-5-aminolevulinate, a lipophilic methyl ester of 5-aminolevulinic acid, with photosensitizer prodrug activity. |
|
V34285 | Moslosooflavone | 3570-62-5 | Moslosooflavoneone is a natural flavonoid extracted from Andrographis paniculata. |
|
V72954 | 6-Deoxyjacareubin | 16265-56-8 | 6-Deoxyjacareubin is a natural xanthone extracted from the leaves of Vismia latifolia. |
|
V106568 | 6PPD | 793-24-8 | 6PPD is a rubber antioxidant that can scavenge ozone and form nitro radicals. |
|
V103050 | 6α-Hydroxy-5α-cholestane | 41083-73-2 | 6α-Hydroxy-5α-cholestane (5α-cholestane-3β,6α-diol) is an oxysterol that enhances superoxide anion production in SK-N-BE cells at concentrations of 50 μM and 100 μM. |
|
V107687 | 8-Hydroxygenistein | 13539-27-0 | 8-Hydroxygenistein (8-OHG) is an antioxidant that can effectively scavenge NO and O2-. |
|
V69158 | 8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) | 83182-58-5 | 8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is an orally bioavailable STAT3 inhibitor. |
|
V105207 | AChE-IN-80 | AChE-IN-80 (Compound 1) is an acetylcholinesterase (AChE) inhibitor. | |
|
V103674 | AChE/BChE-IN-23 | AChE/BChE-IN-23 (compound 6e) is an AChE/BChE inhibitor (IC50 of 0.91 μM, 1.19 μM, and 1.01 μM for AChE, eqBChE, and hBChE, respectively). | |
|
V72967 | AHK | 126828-32-8 | AHK is a biologically active peptide with antioxidant effects and has been reported to be used as an ingredient of cosmetics. |
|
V72928 | Allyl methyl trisulfide | 34135-85-8 | Allyl methyl trisulfide is a volatile organic/chemical reagent and a component of garlic (Allium sativum L. |
|
V87099 | AMC-04 | 792928-94-0 | AMC-04 is an unfolded protein response (UPR) activator that activates the UPR pathway through ROS and p38 MAPK signaling and induces cell apoptosis. |
|
V73391 | Aminoguanidine hemisulfate | 996-19-0 | Aminoguanidine hemisulfate is an inhibitor (blocker/antagonist) of NOS and ROS. |
|
V72947 | Anemarrhenasaponin Ia (Anemarrhenasaponin IA) | 221317-02-8 | Anemarrhenasaponin Ia can be extracted from Anemarrhenae rhizome and inhibits the further production of superoxide induced by fMLP. |
|
V77255 | Anti-inflammatory agent 38 | 3032633-42-1 | Anti-inflammatory agent 38 (compound 23d) is a potent Nrf2/HO-1 inhibitor (antagonist) with IC50 of 0.38 μM for NO. |
|
V88487 | anti-TNBC agent-6 | anti-TNBC agent-6 (compound pt-3) is an effective anti-triple negative breast cancer (TNBC) agent. |
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