Reactive Oxygen Species

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Reactive Oxygen Species

Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.

By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.

Reactive Oxygen Species related products

Cat No.	Product Name	CAS No.	Product Description
V104280	Antiangiogenic agent 7	2527888-07-7	Antiangiogenic agent 7 (Compound 1) can induce cell apoptosis, increase reactive oxygen species (ROS), and inhibit the intracellular enzyme thioredoxin reductase.
V72960	Anticancer agent 15	2710312-73-3	Anticancer agent 15 can significantly increase the level of cellular reactive oxygen species ROS and induce melanoma cell death through necroptosis.
V103855	Anticancer agent 193		The anticancer agent 193 (compound D3-3) is an inducer of ferritin autophagy, ultimately triggering ferroptosis.
V103856	Anticancer agent 194	2767204-90-8	The anticancer agent 194 (compound 10p) is an inducer of ferroptosis and autophagy.
V89454	Anticancer agent 205		Anticancer agent 205 (compound 9) is an effective anticancer agent.
V88957	Anticancer agent 225	2251753-61-2	Anticancer agent 225 (Comp 51) is a triterpene acid analog that inhibits different types of cancer stem cells (CSCs) and increases ROS levels in CSCs.
V86994	Anticancer agent 235	2411108-21-7	Anticancer agent 235 (Compound 49) is a regulator of the PI3K/AKT/mTOR signaling pathway, which can promote the production of reactive oxygen species (ROS), reduce mitochondrial membrane potential, thereby inhibiting the growth of cancer cells HCT116, Caco-2, AGS and SMMC-772.
V105114	Anticancer agent 260	345994-70-9	Anticancer agent 260 (compound 3g/4d) is an orally active anticancer agent that inhibits the proliferation of cancer cells HCT-116, MIA-PaCa2, and MDA-MB231 with IC50 values of 98.7, 81.0, and 77.2 µg/mL, respectively.
V72953	Antioxidant agent-3	2710376-48-8	Antioxidant agent-3 (Compound 14q) is an antioxidant with effective DPPH radical scavenging activity and ABTS+ scavenging activity, with IC50 of 26.58 and 30.31 μM respectively.
V103892	Antitumor agent-139		Antineoplastic agent-139 (compound 9b) is a gold(I) complex that targets the liver and mitochondria, generates reactive oxygen species (ROS) and promotes DNA excretion.
V88538	Antitumor agent-143		Antitumor agent-143 (compound 2c) is an antitumor agent that blocks cell proliferation in the S phase of A549 cells and induces early apoptosis.
V93550	Antitumor agent-188		Antitumor agent-188 (compound C6) has α-glucosidase inhibitory activity and antitumor effects.
V78082	Antitumor photosensitizer-5		Antitumor photosensitizer-5 (Ru2) is a photosensitizer that effectively targets tumor mitochondria, with IC50 of phototoxicity of 0.3 μM for A549 cells.
V72970	Arg-Tyr	74863-12-0	Arg-Tyr is a dipeptide with strong hydroxyl radical and hydrogen peroxide scavenging activity.
V72949	Arochlor 1254	11097-69-1	Arolor 1254 is a polychlorinated biphenyl (PCB) mixture containing biphenyl and 54% chlorine.
V7475	ATF6-activator-147 (AA147)	393121-74-9	AA147 is an ATF6 simulator.
V105176	Autophagy inducer 6		Autophagy inducer 6 (compound 3) inhibited the production of ROS and RNS by inhibiting COX-1 (IC50=15.3 µM) and COX-2 (IC50=4.58 µM).
V72894	Avasopasem manganese (GC-4419; M-40419)	435327-40-5	Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase that can quickly and specifically convert O2*- into hydrogen peroxide (H2O2), preventing the initiation of this cascade reaction.
V90768	Avenanthramide A	108605-70-5	Avenanthramide A is a plant defensin found in oats (Avena sativa L.).
V104923	BC13		BC13 is a CDK6/BRD4 inhibitor with IC50 values of 234 nM and 36 nM for CDK6 and BRD4, respectively.