TLR

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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TLR

A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.

TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.

TLR related products

Cat No.	Product Name	CAS No.	Product Description
V78441	Biotin-labeled ODN 1668 sodium		Biotin-labeled ODN 1668 (sodium) is a class B CpG ODN and a TLR9 agonist.
V78442	Biotin-labeled ODN 1826 sodium		Biotin-labeled ODN 1826 (sodium) is a class B CpG ODN and a TLR9 agonist.
V78443	Biotin-labeled ODN 2088 sodium		Biotin-labeled ODN 2088 (sodium) is a TLR3, TLR7 and TLR9 inhibitor.
V78444	Biotin-labeled ODN 2216 sodium		Biotin-labeled ODN 2216 (sodium) is a TLR9 agonist.
V78445	Biotin-labeled ODN 2395 sodium		Biotin-labeled ODN 2395 (sodium) is a class C CpG ODN and a TLR9 agonist.
V78446	Biotin-labeled ODN TTAGGG sodium		Biotin-labeled ODN TTAGGG (sodium) is an inhibitor oligonucleotide that is an antagonist of TLR9, AIM2 and cGAS.
V87025	BNT411	2296821-50-4	BNT411 is a selective TLR7 agonist that can induce IFNa release in vitro and in vivo.
V74356	Cavrotolimod (AST-008)	2378664-12-9	Cavrotolimod is a spherical nucleic acid (SNA) modified with B-type CpG oligonucleotides that stimulates TLR9 and elicits an immune response.
V78661	Cavrotolimod sodium (AST-008 sodium)		Cavrotolimodsodium is a spherical nucleic acid (SNA) modified with B-type CpG oligonucleotides that stimulates TLR9 and elicits an immune response.
V74376	CAY10614	1202208-36-3	CAY10614 is a potent TLR4 antagonist.
V74360	Chitohexaose hexahydrochloride	127171-88-4	Chitohexaose hexa HCl is a chitosan oligosaccharide with anti-inflammatory activities.
V86903	Chloranil	118-75-2	Chloranil activates the TLR4 signaling pathway by enhancing the expression of TLR4 and MyD88, leading to neuroinflammation and cell damage.
V51783	CL-097	1026249-18-2	CL097 is a potent TLR7 and TLR8 agonist that induces pro-inflammatory cytokines in macrophages.
V51012	CL-104773	802980-92-3	TLR2 antagonists; JAK2 inhibitor
V74355	Cobitolimod	1226822-98-5	Cobitolimod is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity.
V74354	Cobitolimod sodium	1527479-55-5	Cobitolimod sodium is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity.
V87020	CpG ODN 10101 sodium		CpG ODN 10101 sodium is a synthetic oligodeoxynucleotide (ODN) that is a Toll-like receptor 9 (TLR9) agonist.
V51027	CU-115	2471982-20-2	CU-115 is a disabling TLR8 antagonist (IC50=1.04 µM) and shows activity against TLR8 and TLR7 (IC50=>50 µM).
V3815	CU-CPT-8m	125079-83-6	CU-CPT-8m is a novel, potent and specific antagonist ofToll-like receptor 8 (TLR8)with immunomodulatory effects.
V3816	CU-CPT-9a	2165340-32-7	CU-CPT-9a, an analog ofCU-CPT-8m, is a potent and specificantagonist/inhibitor of TLR8 (Toll-like receptor 8) (IC50 = 0.5 nM) with the potential to be used for treating autoimmune diseases.