Acyltransferase

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Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

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Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Acyltransferase

Acyl-coenzyme A (acyl-CoA) transfers an acyl moiety to an acceptor through the action of the enzyme acyltransferase (AT). Acyltransferases have been connected to a number of diseases and are crucial for the maintenance of homeostasis in the human body. The acyl-CoA:cholesterol AT (ACAT), diacylglycerol AT (DGAT), and monoacylglycerol AT (MGAT) are members of the acyltransferase family, which is involved in the metabolism of lipids.

ACAT (acyl-coenzyme A:cholesterol acyltransferase) is an intracellular enzyme that facilitates the conversion of cholesterol and fatty acyl-coenzyme A into cholesterol esters. ACAT1 and ACAT2, two isoenzymes that are encoded by separate genes, are found in mammals. In many tissues, ACATs are crucial for maintaining cellular cholesterol homeostasis.

DGAT (acyl-CoA:diacylglycerol acyltransferase) is an integral membrane enzyme that catalyzes the final step of triacylglycerol synthesis from diacylglycerol and acyl-CoA. Two distinct membrane-bound polypeptides, known as DGAT1 and DGAT2, are where the majority of the DGAT activity is found.

MGAT (acyl-CoA:monoacylglycerol acyltransferase) catalyzes the synthesis of diacylglycerol, the precursor of physiologically significant lipids like triacylglycerol and phospholipids. Because the assembly of the lipoproteins that carry absorbed fat to other tissues depends on the resynthesis of triacylglycerol, MGAT plays a significant role in the absorption of dietary fat in the intestine.

Acyltransferase related products

Cat No.	Product Name	CAS No.	Product Description
V73890	(Rac)-OSMI-1	2748153-92-4	(Rac)-OSMI-1 is the racemate of OSMI-1.
V87270	16-NBD-16:0 Coenzyme A triammonium	1367862-09-6	16-NBD-16:0 Coenzyme A triammonium can be used as a substrate to measure the activity of other acyltransferases in vitro.
V84643	AANAT-IN-1
V4405	ABT-046	1031336-60-3	ABT-046 is a novel, potent, selective, and orally bioavailableinhibitor of diacylglycerol acyltransferase 1 (DGAT-1 ) with IC50 of 8 nM.
V73905	ACAT-IN-10	454203-40-8	ACAT-IN-10 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73898	ACAT-IN-10 dihydrochloride	199983-77-2	ACAT-IN-10 di-HCl is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73895	ACAT-IN-2	199984-55-9	ACAT-IN-2 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73892	ACAT-IN-3	454203-25-9	ACAT-IN-3 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73907	ACAT-IN-4	454203-56-6	ACAT-IN-4 (Example 208) is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73900	ACAT-IN-4 hydrochloride	199984-46-8	ACAT-IN-4 HCl (Example 208) is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73906	ACAT-IN-5	199983-93-2	ACAT-IN-5 (example 19) is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73891	ACAT-IN-6	454203-45-3	ACAT-IN-6 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73893	ACAT-IN-7	199984-38-8	ACAT-IN-7 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73899	ACAT-IN-8	199984-35-5	ACAT-IN-8 (example 206) is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73894	ACAT-IN-9	199984-40-2	ACAT-IN-9 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
V73887	BMS-963272	1441057-15-3	BMS-963272 is a potent and specific MGAT2 inhibitor (IC50 = 7.1 nM) for studying metabolic disorders.
V73897	BMS-986172	1808258-99-2	BMS-986172 is an orally bioactive, selective MGAT2 inhibitor (antagonist) with IC50s of 4.6 nM and 20 nM for hMGAT2 and mMGAT2, respectively.
V19715	DGAT1-IN-1	1449779-49-0	DGAT1-IN-1 is a effective DGAT1 inhibitor (antagonist) with IC50 lower than 10nM (measured by lysate of Hep3B cells overexpressing DGAT1).
V94828	DGAT2-IN-3	3037141-61-7	DGAT2-IN-3 (Compound 9) is a DGAT2 inhibitor with IC50 value of 0.4 nM.
V97349	Diacylglycerol acyltransferase inhibitor-2	2186700-48-9	Diacylglycerol acyltransferase inhibitor-2 (Example 8) is a diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 3.7 nM.