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Aldose Reductase

Aldose Reductase

Aldose reductase is a tiny, cytosolic, monomeric enzyme that is a member of the aldo-keto reductase superfamily. Numerous aromatic and aliphatic carbonyl compounds are reduced by aldose reductase using the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH). It has been linked to the emergence of diabetic and galactosemic complications that affect the kidney, nerves, lens, and retina.

Aldose reductase is a crucial polyol pathway enzyme that, when activated under hyperglycemic conditions, causes the development of chronic diabetic complications. It is also a key factor in the promotion of inflammatory and cytotoxic conditions, even when blood sugar levels are normal. Aldose reductase is a fantastic drug target, and there is a lot of work being done to identify new substances that can inhibit it.

Aldose Reductase related products

Structure Cat No. Product Name CAS No. Product Description
5-Bromo-3-phenyl salicylic acid V87286 5-Bromo-3-phenyl salicylic acid 99514-99-5 5-Bromo-3-phenyl salicylic acid is a selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with Ki value of 140 nM.
6,7-Dihydroxy-4-coumarinylacetic acid V73734 6,7-Dihydroxy-4-coumarinylacetic acid 88404-14-2 6,7-Dihydroxy-4-coumarinylacetic acid is a potent and specific inhibitor of ALR2.
6-Hydroxyluteolin V73729 6-Hydroxyluteolin 18003-33-3 6-Hydroxyluteolin (Compound 17) is a flavonoid compound.
AKR1B10-IN-1 V73733 AKR1B10-IN-1 2136579-33-2 AKR1B10-IN-1 is a potent inhibitor of AKR1B10 with IC50 of 3.5 nM.
AKR1C2/3-IN-1 V87281 AKR1C2/3-IN-1 AKR1C2/3-IN-1 (compound 3a) is a potent AKR1C2 and AKR1C3 inhibitor with IC50 values of 90 and 50 nM, respectively.
AKR1C3-IN-10 V77870 AKR1C3-IN-10 3028287-43-3 AKR1C3-IN-10 (compound 5r) is a selective AKR1C3 inhibitor (IC50=51 nM).
AKR1C3-IN-11 V83455 AKR1C3-IN-11
AKR1C3-IN-12 V87284 AKR1C3-IN-12 891075-67-5 AKR1C3-IN-12 (compound 2j) is an aldehyde-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 27 nM.
AKR1C3-IN-14 V87283 AKR1C3-IN-14 1057882-82-2 AKR1C3-IN-14 (compound 4) is an AKR1C3 inhibitor (IC50=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling.
AKR1C3-IN-9 V73732 AKR1C3-IN-9 2924824-43-9 AKR1C3-IN-9 is a selective inhibitor of aldehyde-keto reductase 1C3 (AKR1C3) with IC50 of 8.92 nM.
Aldose reductase-IN-7 V87285 Aldose reductase-IN-7 Aldose reductase-IN-7 (Compound 6k) targets Aldose reductase and exhibits potent enzyme inhibitory activity (Ki = 0.186 ± 0.020 μM), which is superior to Epalrestat.
ALR2-IN-1 V73731 ALR2-IN-1 2799695-54-6 ALR2-IN-1 is a potent and specific inhibitor of ALR2 (IC50=1.42 μM).
ALR2-IN-2 V80090 ALR2-IN-2 ALR2-IN-2 is a potent aldose reductase (ALR2) inhibitor, with IC50s of 27 nM and 228 nM for rat ALR2 and ALR1 inhibition, respectively.
ALR2-IN-3 V80087 ALR2-IN-3 ALR2-IN-2 is a potent aldose reductase (ALR2) inhibitor, with IC50s of 22 nM and 116 nM for rat ALR2 and ALR1 inhibition, respectively.
ALR2-IN-5 V99021 ALR2-IN-5 ALR2-IN-5 (Compound 10a) is an inhibitor of ALR2 with IC50 value of 99.29 nM.
AT-007 V37639 AT-007 2170729-29-8 AT-007 is a novel and orally bioactive central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM.
Floramanoside A V87278 Floramanoside A 1487423-38-0 Floramanoside A is a flavonol glycoside isolated from the flowers of Abelmouschus manihot.
Floramanoside C V86299 Floramanoside C 1403981-95-2
Floramanoside D V87280 Floramanoside D 1487423-55-1 Floramanoside D is a flavonol glycoside.
Ganoderic acid C6 V73730 Ganoderic acid C6 105742-76-5 Ganoderic acid C6 has aldose reductase inhibitory activity.
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