Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V20588 | ent-Atorvastatin | 501121-34-2 | ent-Atorvastatin [(3S,5S)-Atorvastatin] is an inactive isomer/enantiomer of Atorvastatin, which is a HMGCR (HMG-CoA reductase) inhibitor and an approved blockbuster drug of the statin class of LDL cholesterol-lowering/hypolipidemic drug. |
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V73984 | Eriodictyol chalcone | 14917-41-0 | Eriodictyol chalcone has anti-aromatase and anti-17β-HSD activity. |
|
V20900 | Fadrozole HCl (CGS-16949A) | 102676-31-3 | Fadrozole(CGS 16949A)is a highlypotent and selectivenonsteroidal aromatase inhibitor (IC50 of 6.4 nM) with potential antineoplastic activity. |
|
V69477 | FGFR-IN-10 | 2847092-41-3 | FGFR-IN-10 is an orally bioactive FGFR and Cytochrome P450 (CYP) inhibitor. |
|
V79416 | Fipronil-13C6 (Fipronil-13C6) | Fipronil-13C6 is 13C (carbon 13) labelled Fipronil. | |
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V69497 | FLT3-IN-17 | 2758999-62-9 | FLT3-IN-17 inhibits the activity of CYPs and FLT3 mutants (IC50s: <0.5 nM for D835Y). |
|
V2677 | Fomepizole | 7554-65-6 | Fomepizole (also known as4-methylpyrazole, Antizol, Antizol-Vet)is a competitive inhibitor of alcohol dehydrogenase, an enzyme that catalyzes the initial steps in the metabolism of ethylene glycol,ethanol and methanol to their toxic metabolites. |
|
V21477 | Galangin | 548-83-4 | Galangin (Norizalpinin) is a modulator of arylhydrocarbon receptors and inhibits CYP1A1 activity. |
|
V51359 | Gemfibrozil-d6 (CI-719-d6) | 184986-45-5 | Gemfibrozil-d6 is the deuterium labelled form of Gemfibrozil. |
|
V21549 | Gentiopicrin | 20831-76-9 | Gentiopicrin is a novel and potent bioactive compound and is naturally occurring iridoid glycoside. |
|
V73941 | GSK2945 | 1438071-12-5 | GSK2945 is a tertiary amine and a specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (inhibitor) with EC50s of 21.5 μM and 20.8 μM respectively. |
|
V76956 | GSK2945 hydrochloride | GSK2945 HCl is a tertiary amine and a specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (inhibitor) with EC50s of 21.5 μM and 20.8 μM respectively. | |
|
V70455 | GYKI-47261 dihydrochloride | 1217049-32-5 | GYKI-47261 di-HCl is a competitive, orally bioactive, selective AMPA receptor antagonist (inhibitor) with IC50 of 2.5 μM and displays a broad-spectrum anticonvulsant (antiepileptic/antiseizure) and neuro-protection effects. |
|
V73960 | Harmalol hydrochloride | 6028-07-5 | Harmalol HCl is a beta-carboline alkaloid found in several medicinal plants, such as Peganum harmala. |
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V79720 | hCYP1B1-IN-1 | hCYP1B1-IN-1 (compound B18) is an hCYP1B1 inhibitor (IC50=3.6 nM) and an antagonist of the aryl hydrocarbon receptor. | |
|
V79952 | hCYP3A4-IN-1 | hCYP3A4-IN-1 (compound C6) is an orally bioavailable inhibitor of hCYP3A4. | |
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V73977 | HIV-1 inhibitor-40 | 2789676-44-2 | HIV-1 inhibitor-40 (Compound 4ab) is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1.9 nM. |
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V78821 | HIV-1 inhibitor-58 | HIV-1 inhibitor-58 (Compound 10c) is a broad-spectrum antiviral drug. | |
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V79796 | HIV-IN-9 | HIV-IN-9 (Compound 2b) is an HIV inhibitor (IC50= 6.65 μg/mL) with high binding affinity to HIV-RT. | |
|
V69201 | IHMT-PI3Kδ-372 | 2429889-62-1 | IHMT-PI3Kδ-372 is a potent and specific PI3Kδ inhibitor (antagonist) with IC50 of 14 nM. |
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