Elastase is a group of serine proteases that include the macrophage elastase, the fibroblast elastase, the neutrophil elastase, and the pancreatic elastase.Elastase is able to break down extracellular matrix components like fibronectin, laminin, collagens III, IV, and VI, as well as proteoglycans in addition to the crucial connective tissue protein elastin.
The pancreas and phagocytes are the two main locations for mammalian elastases. There is a wide range of bacterial metallo and serine elastases among non-mammalian elastases. The catalytic efficiency of these proteinases is typically unrelated to the elastolytic activity, which varies from one elastase to another. Elastase inhibitors come in a variety of natural (protein) and artificial forms. Elastases are involved in the pathogenesis of atherosclerosis, cystic fibrosis, infections, and inflammation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V87397 | Neutrophil elastase inhibitor 6 | Neutrophil elastase inhibitor 6 (compound 113) is an irreversible phospho-elastase (neutrophil elastase) inhibitor of human neutrophils. | |
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V73125 | SSR69071 | 344930-95-6 | SSR69071 is a potent, orally bioactive and selective neutrophil elastase inhibitor. |
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V73129 | Suc-AAP-Abu-pNA (Colorimetric Elastase Substrate) | 108392-27-4 | Suc-AAP-Abu-pNA (Colorimetric Elastase Substrate) is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s-1 M-1 for rat pancreatic elastase; Km = 30 μM; Kcat/ Km = 351,000 s-1 M-1 for porcine pancreatic elastase). |
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V73118 | Suc-Ala-Ala-Ala-AMC | 73617-90-0 | Suc-Ala-Ala-Ala-AMC is an elastase or elastase-like peptide substrate. |
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V73127 | Suc-Ala-Pro-Ala-AMC | 88467-44-1 | Suc-Ala-Pro-Ala-AMC is a tripeptide substrate of elastase. |
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V73128 | Tiprelestat | 820211-82-3 | Tiprelestat is a potent human neutrophil elastase inhibitor. |
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V78088 | Tyrosinase/elastase-IN-1 | Tyrosinase/elastase-IN-1 is a triterpenoid compound from Rubus cotyledon, which inhibits the activity of tyrosinase and elastase. | |
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V99652 | VIP236 | 2418533-90-9 | VIP236 is a small molecule drug conjugate (SMDC) consisting of an αvβ3 integrin binder linked to an optimized camptothecin topoisomerase I (TOP1) inhibitor payload. |
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V34235 | Chrysophanol-8-O-beta-D-glucopyranoside | 13241-28-6 | Chrysophanol 8-O-glucoside is developed from the roots of Rumex acetosa and has moderate elastase inhibitory activity. |
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V4184 | freselestat | 208848-19-5 | Freselestat (also known as ONO-6818) is a novel, potent and selective inhibitor of Human Neutrophil Elastase (HNE). |
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V2638 | Sivelestat | 127373-66-4 | Sivelestat (also known as ONO5046; LY544349; EI546) is a novel, potent and competitive inhibitor of human neutrophil elastase (HNE) with IC50value of44 nM andKi of 200 nM; it also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
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V2636 | Sivelestat sodium | 150374-95-1 | Sivelestat sodium, the sodium salt of Sivelestat (also known as ONO5046; LY544349; EI546), is a novel, potent and competitive inhibitor of human neutrophil elastase (HNE) with IC50value of44 nM andKi of 200 nM; it also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
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V4183 | Sivelestat sodium tetrahydrate | 201677-61-4 | Sivelestat sodium tetrahydrate, the sodium tetrahydrate salt of Sivelestat (also known as ONO5046; LY544349; EI546), is a novel, potent and competitive inhibitor of human neutrophil elastase (HNE) with IC50value of44 nM andKi of 200 nM; it also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
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