Elastase is a group of serine proteases that include the macrophage elastase, the fibroblast elastase, the neutrophil elastase, and the pancreatic elastase.Elastase is able to break down extracellular matrix components like fibronectin, laminin, collagens III, IV, and VI, as well as proteoglycans in addition to the crucial connective tissue protein elastin.
The pancreas and phagocytes are the two main locations for mammalian elastases. There is a wide range of bacterial metallo and serine elastases among non-mammalian elastases. The catalytic efficiency of these proteinases is typically unrelated to the elastolytic activity, which varies from one elastase to another. Elastase inhibitors come in a variety of natural (protein) and artificial forms. Elastases are involved in the pathogenesis of atherosclerosis, cystic fibrosis, infections, and inflammation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73121 | 19α-Hydroxyasiatic acid | 70868-78-9 | 19α-Hydroxyasiatic acid is a naturally occurring triterpene with anti-elastase activity. |
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V73126 | Ala-Ala-Pro-Val-chloromethylketone (AAPV-CMK) | 90105-47-8 | Ala-Ala-Pro-Val-chloromethylketone is an irreversible inhibitor of human neutrophil elastase (NE) and may be utilized in the study of chronic inflammatory airway diseases. |
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V1871 | AP-III-a4 (ENOblock) | 1177827-73-4 | AP-III-a4 (also known asENOblock) is a novel and potent small molecule inhibitor of enolase which isisolated by small molecule screening in a cancer cell assay to detect cytotoxic agents that function in hypoxic conditions, which has previously been shown to induce drug resistance. |
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V73130 | Aristololactam IIIa | 97399-89-8 | Aristololactam IIIa significantly inhibits superoxide anion generation and elastase release, with IC50s of 0.12 and 0.20 μg/mL respectively. |
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V4182 | BAY 85-8501 | 1161921-82-9 | BAY 85-8501 is a novel, highly potent and selective inhibitor ofHuman Neutrophil Elastase (HNE)with anIC50of 65 pM. |
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V4165 | BAY-678 | 675103-36-3 | BAY-678 is a novel, potent, orally bioavailable, selective and cell-permeable inhibitor of human neutrophil elastase(HNE) with anIC50of 20 nM. |
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V4166 | BAY-678 racemate | 675103-35-2 | BAY-678 racemate is a racemate of BAY-678 which is a novel, potent, orally bioavailable, selective and cell-permeable inhibitor of human neutrophil elastase(HNE) with anIC50of 20 nM. |
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V99823 | CDD-3290 | CDD-3290 (Compound 20) is a prostate-specific antigen (PSA) inhibitor with a Ki value of 216 nM. | |
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V73123 | Cyclotheonellazole A | 2094993-48-1 | Cyclotheonellazole A is a natural macrocyclic peptide and a potent elastase inhibitor (IC50=0.034 nM). |
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V73119 | Elastase from porcine pancreas (EC 3.2.1.35) | 39445-21-1 | Elastase from porcine pancreas is a single polypeptide chain of 240 amino acid (AA) residues derived from porcine pancreas. |
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V76999 | Freselestat quarterhydrate (ONO-6818 quarterhydrate; ONO-PO-736 quarterhydrate) | Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally bioactive neutrophil elastase inhibitor (antagonist) with Ki of 12.2 nM. | |
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V73117 | KLK7/ELA2-IN-1 | 1122484-55-2 | KLK7/ELA2-IN-1 is a potent inhibitor of kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) with IC50 of 6 nM and 55 nM, respectively (WO2009024527A1, Example 4). |
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V73120 | Lonodelestat (POL6014) | 906547-89-5 | Lonodelestat (POL6014) is a potent, orally bioactive, selective peptide inhibitor of human neutrophil elastase (hNE). |
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V76812 | Lonodelestat TFA (POL6014 TFA) | Lonodelestat TFA (POL6014 TFA) is a potent, orally bioactive, selective peptide inhibitor of human neutrophil elastase (hNE). | |
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V79774 | MeOSuc-AAPA-CMK | MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase. | |
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V73046 | MeOSuc-AAPV-CMK (Elastase Inhibitor III) | 65144-34-5 | MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. |
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V73122 | MeOSuc-Ala-Ala-Pro-Met-AMC | 201853-55-6 | MeOSuc-Ala-Ala-Pro-Met-AMC is a bioactive peptide substrate for elastase and chymotrypsin-like serine peptidase. |
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V87398 | Neutrophil elastase inhibitor 3 | 1234707-32-4 | Neutrophil elastase inhibitor 3 (compound 13), a benzoxazolone analogue, has an effect on superoxide anion generation and exhibits an inhibitory effect on neutrophil elastase (NE), which inhibits NE release. |
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V79855 | Neutrophil elastase inhibitor 4 | Neutrophil elastase inhibitor 4 (compound 4f) is a competitive human neutrophil elastase (HNE) inhibitor (IC50= 42.30 nM, Ki: 8.04 nM). | |
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V79118 | Neutrophil elastase inhibitor 5 | 3020696-44-7 | Neutrophil elastase inhibitor 5 (compound 29) is a dual (bifunctional) inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3), with IC50s of 4.91 μM and 20.69 μM respectively. |
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