HDAC (Histone Deacetylases) are a group of enzymes that allow histones to more tightly wrap the DNA by removing acetyl groups (O=C-CH3) from -N-acetyl lysine amino acids. This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V55231 | HL23 | 1448355-15-4 | HL23 is a histone deacetylase (HDAC) inhibitor (antagonist) with anti-hepatocellular carcinoma (HCC) activity. |
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V52892 | ITF 3756 | 2247608-27-9 | ITF 3756 is a potent and specific HDAC6 inhibitor. |
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V2087 | ITSA-1 | 200626-61-5 | ITSA-1 is a novel, potent, cell-membrane permeable and specific HDAC (Histone deacetylase) activator that suppressesTSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. |
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V12132 | KA2507 monohydrochloride | 2972712-63-1 | KA2507 HCl is a highly efficient and selective HDAC6 inhibitor (IC50=2.5 nM) without obvious toxicity. |
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V75845 | KPZ560 | 2397562-43-3 | KPZ560 is a potent inhibitor of HDAC1 and HDAC2 with IC50 of 12 nM and 68 nM respectively. |
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V55242 | KT-531 | 2490284-18-7 | KT-531 is a potent and specific inhibitor of HDAC6 with IC50 of 8.5 nM. |
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V55232 | LW479 | 1688677-89-5 | LW479 is a new HDAC inhibitor and is expected to be a candidate active molecule for the prevention of breast cancer. |
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V53365 | MOCPAC | 787549-26-2 | MOCPAC is an HDAC1-specific substrate. |
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V41169 | MPT0G211 | 2151853-97-1 | MPT0G211 is a potent, orally bioactive and selective HDAC6 inhibitor (IC50=0.291 nM). |
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V41170 | MPT0G211 mesylate | 2151854-33-8 | MPT0G211 mesylate is a potent, orally bioactive and selective HDAC6 inhibitor (IC50=0.291 nM). |
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V25171 | NKL 22 | 537034-15-4 | NKL 22 (compound 4b) is a potent and specific histone deacetylase (HDAC) inhibitor (antagonist) with IC50s of 199 and 69 nM for HDAC1 and HDAC3, respectively. |
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V11393 | NR-160 | NR-160 is a novel, potent and selective HDAC6 (Histone Deacetylase 6) inhibitors with bifurcatedcapping groups. | |
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V41097 | NR160 | 2484895-50-1 | NR160 is a selective HDAC6 inhibitor (antagonist) with IC50 of 30 nM. |
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V41088 | NT160 | 1418293-40-9 | NT160 is a potent class IIa HDAC inhibitor (antagonist) with IC50 of 0.046 μM. |
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V55235 | PB131 | 2924425-63-6 | PB131 is a selective, brain barrier-penetrating HDAC6 inhibitor (antagonist) with high binding affinity (IC50= 1.8 nM). |
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V13533 | Quisinostat HCl | 1083078-98-1 | Quisinostat HCl (formerly JNJ-26481585; JNJ 26481585; JNJ26481585), the hydrochloride salt ofQuisinostat, is an orally bioavailable, 2nd generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antitumor activity. |
|
V36625 | SHP2/HDAC-IN-1 | 2831230-38-5 | SHP2/HDAC-IN-1 is an allosteric dual SHP2/HDAC inhibitor (antagonist) with IC50s of 20.4 nM (SHP2) and 25.3 nM (HDAC1). |
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V32595 | Sodium Butyrate | 156-54-7 | Sodium Butyrate, the sodium salt of butyrate, is ashort-chainfattyacid acting asan histone deacetylase (HDAC) inhibitor with anticancer activity. |
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V55229 | SP-2-225 | 2364448-93-9 | SP-2-225 is a selective HDAC6 inhibitor. |
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V3192 | SR-4370 | 1816294-67-3 | SR-4370 is an inhibitor ofHDAC (Histone deacetylases), withIC50values of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. |
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