Histone acetyltransferases (HATs) are epigenetic proteins that attach acetyl groups to lysine residues in cellular proteins like histones, transcription factors, nuclear receptors, and enzymes. In eukaryotic cells, HATs are essential for chromatin remodeling and transcriptional control. Through the acetylation of both histone and non-histone proteins, HATs have been shown to play a role in diseases ranging from cancer and inflammatory disorders to neurological disorders.
At least five different subfamilies of HATs (HAT1, Gcn5/PCAF, MYST, p300/CBP, and Rtt109) can be distinguished. HATs mediate a wide range of biological functions, such as hormone signaling, dosage adjustment, DNA damage repair, and cell cycle progression. A number of human diseases, such as solid tumors, leukemias, inflammatory lung disease, viral infection, diabetes, fungus infection, and drug addiction, are associated with abnormal HAT function.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V80218 | MOZ-IN-3 | MOZ-IN-3 (Compound 6j) is a KAT6A (MOZ) acetyltransferase inhibitor (IC50= 30 nM). | |
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V41109 | NUR | 2674753-39-8 | NiCur is a potent and specific CBP histone acetyltransferase (HAT) inhibitor (antagonist) with IC50 of 0.35 μM. |
|
V85795 | P300-IN-1 | 2488868-36-4 | |
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V56063 | Pocenbrodib | 2304372-79-8 | Pocenbrodib (compound II) is a bromodomain inhibitor of the CBP/p300 family. |
|
V83402 | QC-182 | ||
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V0377 | Ranolazine (CVT303, RS43285-003; Ranexa) | 95635-55-5 | Ranolazine (formerly CVT-303, RS 43285-003; brand name Ranexa)is a approved anti-angina drug used to treat chronic angina. |
|
V2042 | Remodelin | 949912-58-7 | Remodelin is a novel, selective and potent acetyl-transferase NAT10 inhibitor that is cell-permeable and stable analog of CPTH2. |
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V2521 | Remodelin HBr | 1622921-15-6 | Remodelin HBr, the hydrobromide salt of Remodelin and acell-permeable and stable analog of CPTH2, is an acetyl-transferase NAT10 inhibitor. |
|
V4409 | TTK21 | 709676-56-2 | TTK21 is an activator of the histone acetyltransferase CBP/p300. |
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V56066 | Windorphen | 19881-70-0 | Windorphen is a Wnt/β-catenin signaling inhibitor that specifically targets the function of the C-terminal transactivation domain of β-catenin-1 but not β-catenin-2. |
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V2436 | WM 3835 | 2229025-70-9 | WM-3835 (WM3835) is a novel and potent lysine acetyltransferase HBO1 (KAT7) inhibitor with potential anticancer activity. |
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V3686 | WM-1119 | 2055397-28-7 | WM-1119 (WM1119) is a novel, highly potent, and selective inhibitor ofhistone acetyltransferase KAT6A/B (lysine acetyltransferase) with potential anticancer activity. |
|
V31859 | WM-8014 | 2055397-18-5 | WM-8014 (WM8014; MOZ-IN3; MOZ-IN-3) is a novel, potent andprototypical inhibitor of MOZ (IC50 = 55 nM) which is a member of histone acetyltransferases with anticancer activity. |
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