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Histone Acetyltransferase

Histone Acetyltransferase

Histone acetyltransferases (HATs) are epigenetic proteins that attach acetyl groups to lysine residues in cellular proteins like histones, transcription factors, nuclear receptors, and enzymes. In eukaryotic cells, HATs are essential for chromatin remodeling and transcriptional control. Through the acetylation of both histone and non-histone proteins, HATs have been shown to play a role in diseases ranging from cancer and inflammatory disorders to neurological disorders.
At least five different subfamilies of HATs (HAT1, Gcn5/PCAF, MYST, p300/CBP, and Rtt109) can be distinguished. HATs mediate a wide range of biological functions, such as hormone signaling, dosage adjustment, DNA damage repair, and cell cycle progression. A number of human diseases, such as solid tumors, leukemias, inflammatory lung disease, viral infection, diabetes, fungus infection, and drug addiction, are associated with abnormal HAT function.

Histone Acetyltransferase related products

Structure Cat No. Product Name CAS No. Product Description
KAT6-IN-1 V53267 KAT6-IN-1 2569008-99-5 KAT6-IN-1 is a potent inhibitor of KAT6.
KAT6-IN-2 V96667 KAT6-IN-2 KAT6-IN-2 (Compound 25) is a potent KAT6 inhibitor.
KAT6-IN-3 V94599 KAT6-IN-3 KAT6-IN-3 (Compound 10) competitively targets KAT6A and KAT6B.
KAT6A-IN-1 V94515 KAT6A-IN-1 2991087-72-8 KAT6A-IN-1 (Compound 5) is a KAT6A inhibitor.
KAT6A-IN-2 V94588 KAT6A-IN-2 2991087-74-0 KAT6A-IN-2 (Compound 7) is a KAT6A inhibitor.
Lys-CoA TFA V76803 Lys-CoA TFA Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50=50-500 nM).
MC4171 V79730 MC4171 MC4171 (Compound 34) is a selective KAT8 inhibitor (IC50=8.1 µM).
MG149 V2520 MG149 1243583-85-8 MG-149 (MG149) is a novel, potent and selectivehistone acetyltransferase (HAT) inhibitor with anticancer activity.
MJP6412 V93930 MJP6412 MJP6412 is a potent p300/CBP degrader with DC50 values of 1.6 nM and 1.2 nM for p300 and CBP, respectively.
MOZ-IN-3 V80218 MOZ-IN-3 MOZ-IN-3 (Compound 6j) is a KAT6A (MOZ) acetyltransferase inhibitor (IC50= 30 nM).
N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide V3344 CTB 451491-47-7 CTB (also known as Cholera Toxin B subunit) is a potent activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
NAT1-IN-1 V101081 NAT1-IN-1 NAT1-IN-1 (Compound 350) is a potent targeted inhibitor of N-acetyltransferase 1 (NAT1) with IC50 of 44 nM.
NiCur V41109 NUR 2674753-39-8 NiCur is a potent and specific CBP histone acetyltransferase (HAT) inhibitor (antagonist) with IC50 of 0.35 μM.
P300-IN-1 V85795 P300-IN-1 2488868-36-4
P300-IN-4 V103639 P300-IN-4 P300-IN-4 (Compound 6) is a histone acetyltransferase p300 inhibitor with IC50 of 12.2 μM.
Pocenbrodib V56063 Pocenbrodib 2304372-79-8 Pocenbrodib (compound II) is a bromodomain inhibitor of the CBP/p300 family.
QC-182 V83402 QC-182 3032646-96-8
Remodelin V2042 Remodelin 949912-58-7 Remodelin is a novel, selective and potent acetyl-transferase NAT10 inhibitor that is cell-permeable and stable analog of CPTH2.
Remodelin氢溴酸盐 V2521 Remodelin HBr 1622921-15-6 Remodelin HBr, the hydrobromide salt of Remodelin and acell-permeable and stable analog of CPTH2, is an acetyl-transferase NAT10 inhibitor.
TTK21 V4409 TTK21 709676-56-2 TTK21 is an activator of the histone acetyltransferase CBP/p300.
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