JAK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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JAK

Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway.Members of the type I and type II cytokine receptor families depend on the JAK family of tyrosine kinases to phosphorylate and activate downstream proteins involved in their signal transduction pathways because they lack catalytic kinase activity.The receptors have two intracellular signal-transducing domains because they are paired polypeptides. Each intracellular domain contains a proline-rich region called a box1/box2 region that is close to the cell membrane and where JAKs bind. The two JAKs are brought close enough to phosphorylate one another after the receptor undergoes a conformational change following association with the corresponding cytokine or ligand. By further phosphorylating and activating STAT transcription factors, JAK autophosphorylation causes a conformational change within itself, enabling it to transduce the intracellular signal. When STATs are activated, they separate from their receptor and coalesce into dimers before moving into the cell nucleus, where they control the transcription of particular genes.

JAK related products

Cat No.	Product Name	CAS No.	Product Description
V51516	SJ-1008030	2863634-96-0	SJ1008030 (compound 8) is a JAK2 PROTAC that selectively degrades JAK2.
V53150	SJ10542	2789678-92-6	SJ10542 is a potent and specific JAK2/3-directed phenylglutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively.
V15932	TCJL-37	1258294-34-6	TCJL37 is a potent, orally bioactive and selective TYK2 inhibitor (antagonist) with Ki of 1.6 nM.
V106289	Tkip	716361-65-8	Tkip is a specific inhibitor of JAK2. It can bind to the JAK2 autophosphorylation site, inhibit JAK2 autophosphorylation and the phosphorylation of the IFN-γ receptor subunit IFNGR-1, inhibit the antiviral activity of IFN-γ and the expression of MHC class I molecules, and can be used for research related to the IFN-γ signaling pathway.
V51510	TUL-01101	2411222-97-2	TUL01101 is a specific and orally bioactive JAK1 inhibitor (antagonist) with IC50s of 3, 37, 1517 and 36 nM for JAK1, JAK2, JAK3 and TYK2 respectively.
V35164	TX-1123	157397-06-3	TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor targeting Src, eEF2-K, PKA and EGFR-K/PKC.
V56092	TYK2 JH2-IN-1-d3	2376999-19-6	TYK2 JH2-IN-1-d3 is a deuterated, orally bioactive and selective TYK2 inhibitor (compound 4h) targeting the JH2 domain (IC50=0.1 nM).
V88973	TYK2 ligand 1	2770471-05-9	TYK2 ligand 1 is a ligand of TYK2 and can be used to synthesize TYK2 PROTAC degrader (CPD-155).
V86065	Tyk2-IN-14	2308520-97-8
V83499	Tyk2-IN-15	3010873-44-3
V88969	Tyk2-IN-16	3010874-30-0	Tyk2-IN-16 is a selective and potent TYK2 inhibitor with IC50 of <10 nM for TYK2-JH2.
V88897	Tyk2-IN-17	3010874-31-1	Tyk2-IN-17 (compound 185) is a potent TYK2 inhibitor.
V89063	Tyk2-IN-18	3024860-29-2	Tyk2-IN-18 (compound 86) is a potent tyrosine kinase 2 (Tyk2) inhibitor.
V83373	Tyk2-IN-18-d5	3018160-63-6
V88896	Tyk2-IN-19	2866415-98-5	Tyk2-IN-19 (compound 1) is an orally active and blood-brain barrier permeable Tyk2 inhibitor.
V93215	Tyk2-IN-20	3058568-08-1	Tyk2-IN-20 (Example 289) is a potent Tyk2 inhibitor with IC50 value <5 nM.
V104918	TyK2-IN-21-d3	2583719-08-6	TyK2-IN-21-d3 (compound 3c) is an oral prodrug of tyrosine kinase 2.
V104314	Tyk2-IN-22	933667-23-3	Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), inhibiting Tyk2, JAK1 and JAK3 with IC50 of 9.7, 148.6 and 883.3 nM, respectively.
V35163	Tyrphostin AG213 (AG213)	122520-86-9	Tyrphostin AG213 (AG213) is an epidermal growth factor receptor (EGFR) protein tyrosine kinase inhibitor (IC50=0.85 μM).
V51514	VVD-118313	2875046-27-6	VVD-118313 (compound 5a) is a potent selective JAK1.